Buch, Englisch, 306 Seiten, Format (B × H): 157 mm x 235 mm
No. 224
Buch, Englisch, 306 Seiten, Format (B × H): 157 mm x 235 mm
Reihe: Novartis Foundation Symposium
ISBN: 978-0-471-98827-4
Verlag: Wiley
Brings together key new results of interdisciplinary collaborations among various research fields on rhodopsin including the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina and other transduction processes in the retina and brain.
The structures of the rhodopsin molecule are studied in the fields of protein chemistry, molecular biology, organic chemistry and structural biology; the ultra fast reactions of the retinal protein are studied in physics, biophysics, physical chemistry, organic chemistry and photobiology; the phototransduction in retinal proteins and visual cells are studied in biophysics, biochemistry, biophysical chemistry and photobiology; and the localization in the tissues is studied in anatomy and histochemistry. The diversity of visual systems in various animals is studied in zoology and comparative biochemistry.
Rhodospins, sometimes called "retinal proteins," are photosensitive proteins that function as the photoreceptors for visual transduction and extraocular systems. This book presents the perspective of various research fields on such topics as the structures of the rhodospin molecule, the ultrafast reactions of the retinal proteins and visual cells, and the localization in the tissues. The diversity of visual systems in various animals is also investigated.
Rhodopsine sind lichtempfindliche Proteine, deren Chromophor als Retinal (Vitamin-A-Aldehyd) fungiert. In den letzten Jahren stellte sich heraus, daß die Rhodopsine zu einer großen Familie von Rezeptoren gehören und daß deren allgemeiner Mechanismus der Signaltransduktion weit verbreitet ist. Neueste Forschungsergebnisse auf dem Gebiet der Biophysik visueller Rezeptoren faßt diese Monographie zusammen, deren Beiträge von der Strukturchemie bis zur Neurophysiologie reichen. (08/99)
Rhodopsins and Phototransduction Chair: Tôru Yoshizawa 1999 Rhodopsins are.photosensitive proteins with a retinal as the chromophore, and are composed of seven transmembrane helices embedded in the membranes. They function as the photoreceptor proteins for visual transduction and extraocular systems. Upon absorption of light the region-specific isomerization of the retinal chromophore takes place, which is the switching mechanism of the visual transduction process and induces a conformational change of the protein moiety in the rhodopsin molecule. Metarhodopsin II, an intermediate in the bleaching process of rhodopsin, interacts with a G protein and mediates the light signal for further transduction processing in the visual cell. In the past few years, it has been shown that rhodopsin belongs to a large receptor family and that the general mechanism of the signal transduction mediated by this receptor family is almost universal. Fully interdisciplinary, this book brings together protein chemists, molecular biologists, structural biologists, biophysicists, biochemists and photobiologists to discuss their work. Recent data are presented on the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina, and other transduction processes in the retina and brain. This book is dedicated to the memory of George Wald.
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Proteinforschung
- Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
- Naturwissenschaften Physik Angewandte Physik Biophysik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
- Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
Weitere Infos & Material
Professor George Wald Memorial Talk
RUTH HUBBARD and ELIJAH WALD
The ecology of visual pigments
J K BOWMAKER
Evolution of visual pigments and related molecules
FUMIO TOKUNAGA
Structure of rhodopsin obtained by electron cryo-microscopy
GEBHARD F X SCHERTLER
Photons, femtoseconds and dipolar interactions: a molecular picture of the primary events in vision
RICHARD A MATHIES
Photoactivation of rhodopsin: interplay between protein and chromophore
WILLEM J DEGRIP
Colour tuning mechanism of visual pigments
STEVEN W LIN
Amino acid residues controlling properties and functions of rod and cone visual pigments
YOSHINORI SHICHIDA
Signalling states of photoactivated rhodopsin
KLAUS PETER HOFMANN
Molecular mechanism of visual transduction
KRZYSZTOF PALCZEWSKI
Calcium-dependent regulation of rhodopsin phosphorylation
SATORU KAWAMURA
Emerging role of mass spectrometry in molecular biosciences: studies of protein phosphorylation in fly eyes as an example
HIROYUKI MATSUMOTO
Cyclic GMP-gated channel and peripherin/rds-rom-1 complex of rod cells
ROBERT S MOLDAY
Non-visual photoreception by a variety of vertebrate opsins
DAISUKE KOJIMA
