Synthetic Biology in Medicine

Tools and Transformative Therapies
Erscheinungsjahr 2027
ISBN: 978-0-443-49344-7
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 152 mm x 229 mm

Synthetic Biology in Medicine: Tools and Transformative Therapies covers the design and optimization of artificial biological components, gene editing systems, principles for designing and constructing artificial gene circuits, cell engineering, delivery systems of artificial biomolecules, and the prospects and challenges of synthetic biology technologies applied in drug development. The book contains many application cases related to clinical practice and industry, offering references for solving industrial pain points.

Autoren/Hrsg.

Zhen, Xie

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Chapter 1: Introduction
1. The Rise and Development of Medical Synthetic Biology
2. Application Fields of Medical Synthetic Biology
3. Research Ideas of Medical Synthetic Biology
4. Prospects and Challenges of Medical Synthetic Biology

Chapter 2: Design and Optimization of Artificial Biological Components
5. Introduction to Biological Components
6. Rational Design of Biological Components
7. Intelligent Design of Biological Components
8. Development Trends in the Design and Optimization of Biological Components

Chapter 3: Gene Editing
9. DNA Editors
10. RNA Editors
11. Prime Editors
12. Prospects

Chapter 4: Artificial Gene Circuits
13. Mechanisms of Gene Circuits
14. Principles for Constructing Gene Circuits
15. Classical Gene Circuits
16. Computer-Assisted Strategies for Gene Circuit Construction

Chapter 5: Cell Engineering
17. Immune Cell Engineering
18. Stem Cell-Derived Cell Engineering
19. Bacterial Engineering
20. Summary

Chapter 6: Delivery Systems for Artificial Biomolecules
21. Viral Delivery Vectors
22. Non-Viral Delivery Vectors
23. Medical Application Scenarios of Different Delivery Vectors
24. Summary and Outlook

Chapter 7: Prospects and Challenges of Synthetic Biology in Drug Development
25. Clinical Application Prospects of Synthetic Biology Technologies
26. Case Studies of Synthetic Biology in Drug Development
27. Challenges Facing Synthetic Biology in Drug Development

Über Autor(innen)

Zhen, Xie
Dr Xie Zhen is based at the Institute of Information Processing, Tsinghua University and the Center for Synthetic and Systems Biology, Tsinghua University. He is a Tenured Associate Professor. Dr Zhen is Chair of the Synthetic Biotechnology Branch of the China Medicinal Biotechnology Association; Member of the Professional Committee of Bioinformatics and Artificial Life of the Chinese Association for Artificial Intelligence; and a Member of the Synthetic Biology Professional Committee of the Chinese Society of Biotechnology.

His research interests include: synthetic biology, cancer therapy, and the design and control of artificial molecular machines