Abraham / Handler / Dashwood Vascular Complications in Human Disease

Mechanisms and Consequences
1. Auflage 2008
ISBN: 978-1-84628-919-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 258 Seiten, eBook

Arterial disease and inflammation are fundamental causes of many medical conditions. Recently, there have been several major advances in our understanding of the causes of diseases affecting the heart, lungs, kidneys, skin and blood vessels. The role of endothelium derived growth factors, nitric oxide and other messengers in vascular disease has been more clearly defined. New treatments targeting these molecular disorders are being used with beneficial effects. Further progress depends on a combined approach embracing basic and clinical research so that treatments of common, important diseases can be designed intelligently and logically. "Vascular Complications in Human Disease" presents our understanding of vascular disease, in reviews of the main strands of basic and clinical research written by leading international experts. It also identifies routes for further fruitful research and development. This concise and carefully edited book, avoiding repetition, includes the full spectrum of basic research which is not covered in other textbooks.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Abraham, David

Handler, Clive

Dashwood, Michael

Coghlan, Gerry

Inhaltsverzeichnis

Treatments for Pulmonary Vascular Disease.- Therapy for Pulmonary Vascular Disease: Past, Present, and Future.- Nitric Oxide Axis in Cardiopulmonary Disease.- Endothelin Signaling in the Cardiomyocyte.- TGF-?/BMP Signaling in Pulmonary Vascular Disease.- Model Systems.- Endothelin System in Chronic Kidney Disease.- Endothelial Activation in Inflammation: Lessons Learned from E-Selectin.- Pathogenic Mediators of Vessel Sclerosis: Regulation of Vascular Smooth Muscle Cell Proliferation by Growth Factors, the Extracellular Matrix, and the Endothelium.- Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins.- Vascular Complications.- Vascular Complications of Systemic Sclerosis: A Molecular Perspective.- Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury.- Surgical Approaches.- Current State of Medical Therapies for Peripheral Vascular Disease.- Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the “No-Touch” Technique.- Toward the Prevention of Vein Graft Failure.- Genetics, Gene Therapy, and Tissue Engineering.- Statins and Cholesterol: How Low Can You Go?.- Endothelin-1-Promoting Actions in the Growth and Angiogenesis of Solid Cancers.- Gene Therapy for Apolipoprotein A-I and HDL—The Ultimate Treatment for Atherosclerosis.- ETS Family of Transcription Factors and the Vascular System.- Aortic Valve: From Function to Tissue Engineering.

Über Autor(innen)

Professor Dame Carol Black DBE, PRCP, President of the Royal College of Physicians, Professor and Head Of Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK.Professor David Abraham PhD, Head of Research, Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK.Dr Gerry Coghlan MD, Consultant Cardiologist, Director of the Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK.Dr Michael Dashwood, PhD, Senior Lecturer in Biochemistry, University College London, UK.Dr Christopher Denton, PhD, Senior Lecturer and Consultant Rheumatologist, The Royal Free Hospital and University College London, UK.Dr Clive Handler MD, Honorary Consultant, Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK.All the authors are internationally respected and leading clinical and basic scientists and clinicians.