Alt Advances in Immunology

1. Auflage 2009
ISBN: 978-0-08-088833-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 101, 264 Seiten

Reihe: Advances in Immunology

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field

Autoren/Hrsg.

Alt, Frederick W.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Immunology;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Chapter 1:TSLP in Epithelial Cell and Dendritic Cell Cross Talk;12
6.1;1. Introduction;13
6.2;2. Thymic Stromal Lymphopoietin (TSLP) and TSLP Receptor (TSLPR);13
6.3;3. TSLP in Lymphocyte Development in Mice;14
6.4;4. TSLP Activates Human Myeloid Dendritic Cells;15
6.5;5. TSLP in Allergic Inflammation;16
6.6;6. TSLP in Peripheral CD4+ T Cell Homeostasis;23
6.7;7. TSLP in the Development of Regulatory T Cells in Thymus;25
6.8;8. Summary and Future Perspectives;28
6.9;Acknowledgments;30
6.10;References;31
7;Chapter2: Natural Killer Cell Tolerance: Licensing and Other Mechanisms;38
7.1;1. Introduction: Natural Killer Cells and "Missing Self";40
7.2;2. NK Cell Receptors: The KIR and Ly49 Families;40
7.3;3. Early Models of NK Cell Self-Tolerance;42
7.4;4. NK Cell Licensing;45
7.5;5. NK Cell Tolerance in MHC Class I Chimeric and Mosaic Mice;64
7.6;6. Other Safeguards of NK Cell Tolerance to Self;68
7.7;7. NK Cell Tolerance Mechanisms in the Clinic;74
7.8;8. Concluding Remarks;77
7.9;Acknowledgments;78
7.10;References;78
8;Chapter3: Biology of the Eosinophil;92
8.1;1. The Eosinophil: From a Hematopoietic Stem Cell to a Mature Eosinophil;93
8.2;2. A Role for Eosinophils at Baseline;99
8.3;3. Eosinophils and Immune Regulation;101
8.4;4. Eosinophil Trafficking;102
8.5;5. Role of Eosinophils in Disease;107
8.6;6. Antieosinophil Therapeutics;116
8.7;Acknowledgments;119
8.8;References;119
9;Chapter4: Basophils: Beyond Effector Cells of Allergic Inflammation;134
9.1;1. Introduction;135
9.2;2. Development and Inflammatory Mediator Content;136
9.3;3. Cell-Surface Markers;138
9.4;4. Human Basophil Cytokine Secretion;145
9.5;5. Basophil Participation in Human Disease;150
9.6;6. Basophils in Mouse Models of Th2 Inflammation;157
9.7;7. Concluding Remarks;162
9.8;References;163
10;Chapter5: DNA Targets of AID: Evolutionary Link Between Antibody Somatic Hypermutation and Class Switch Recombination;174
10.1;1. Introduction;175
10.2;2. Experimental Systems to Study S Regions;178
10.3;3. S Regions;179
10.4;4. V Regions;185
10.5;5. Sequence Comparison of V, S, and Non-Ig AID Targets;185
10.6;6. The Susceptibility of Non-S Regions to Mediate CSR;190
10.7;7. AID Recruitment to Target Sequences;191
10.8;8. Role of DNA Double Strand Break (DSB);191
10.9;9. Evolutionary Link between SHM and CSR;193
10.10;References;194
11;Chapter6: Interleukin 5 in the Link Between the Innate and Acquired Immune Response;202
11.1;1. Introduction;204
11.2;2. IL-5 and Signal Transduction;207
11.3;3. IL-5-Receptor-Mediated Signaling;212
11.4;4. IL-5 Augments Innate Immune Response;215
11.5;5. IL-5 Modulates Acquired Immune Response;219
11.6;6. IL-5 Links Innate and Acquired Immunity In Disease Model;227
11.7;7. Future Perspectives;231
11.8;Acknowledgments;233
11.9;References;233
12;Subject Index;248
13;Contents of Recent Volumes;256
14;Color Plates Section;262