Alt Advances in Immunology

1. Auflage 2011
ISBN: 978-0-12-387703-1
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 109, 222 Seiten

Reihe: Advances in Immunology

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field

Autoren/Hrsg.

Alt, Frederick W.

Inhaltsverzeichnis

1;Front Cover;1
2;Immunology;4
3;Copyright;5
4;Contents;6
5;Contributors;8
6;Chapter 1: Dynamic Palmitoylation and the Role of DHHC Proteins in T Cell Activation and Anergy;10
6.1;1. Introduction;11
6.2;2. T Lymphocyte Activation and Anergy;13
6.3;3. Protein Palmitoylation (S-acylation);17
6.4;4. Palmitoylation in T Lymphocytes;27
6.5;5. Concluding Remarks and Perspective;39
6.6;Acknowledgments;40
6.7;References;41
7;Chapter 2: Transcriptional Control of Natural Killer Cell Development and Function;54
7.1;1. Natural Killer Cells;55
7.2;2. NK Cell Development;57
7.3;3. Transacting Factors in NK Cell Development;60
7.4;4. Transacting Factors in Mature NK Cell Function;75
7.5;5. Conclusions;82
7.6;Note In Proof;82
7.7;References;82
8;Chapter 3: The Control of Adaptive Immune Responses by the Innate Immune System;96
8.1;1. Introduction;97
8.2;2. Diverse Sets of PRRs;98
8.3;3. Cell-Type-Specific PRR Distribution and the Interplay Between PRRs in Adaptive Immunity;106
8.4;4. Innate Control of CD4+ T Cell Responses;108
8.5;5. B Cell-Intrinsic Control of Humoral Immune Responses by PRRs;115
8.6;6. Pathological Consequences of Defective PRR Signaling in Humans;117
8.7;7. Conclusions;119
8.8;Acknowledgments;120
8.9;References;121
9;Chapter 4: The Evolution of Adaptive Immunity in Vertebrates;134
9.1;1. Introduction;135
9.2;2. Immune Response Molecules in Invertebrates and Plants;136
9.3;3. Emergence of Lymphocytes and Genes Connected with Mammalian Immunity in Jawless Vertebrates;138
9.4;4. AIS in Jawed Vertebrates;139
9.5;5. VLR-based AIS in Jawless Vertebrates;147
9.6;6. Conclusions;156
9.7;Acknowledgments;159
9.8;References;159
10;Chapter 5: T Helper Cell Differentiation: More than Just Cytokines;168
10.1;1. Introduction: T Helper Cells;169
10.2;2. T Helper Cell Subset Identities;170
10.3;3. The Role of Cytokines in T Helper Cell Differentiation;171
10.4;4. Strength of Signaling;180
10.5;5. Environmental Factors;188
10.6;6. Conclusion;191
10.7;Acknowledgments;191
10.8;References;191
11;Index;206
12;Contents of recent volumes;212