Arcos / Argus / Wolf Chemical Induction of Cancer

Structural Bases and Biological Mechanisms
1. Auflage 2013
ISBN: 978-1-4832-2372-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 516 Seiten, Web PDF

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume I discusses the role of chemicals in the genesis of cancer in man. This book is organized into two parts encompassing four chapters that also present the concepts and techniques of testing chemicals for carcinogenic potential. After an introduction to the distinctions between normal and neoplastic cells, this book goes on describing the structure of potential carcinogens, including alkanes, alkenes, alkynes, and aromatic hydrocarbons. The next chapter deals with the role of intra- and intermolecular forces of chemicals in their carcinogenic activity. The last chapter discusses some aspects of the pathology of chemically-induced tumors. This chapter also provides the concept and testing procedures of animal assays. This book is of great value to oncologists, pathologists, and general medical practitioners.

Autoren/Hrsg.

Arcos, Joseph C.

Argus, Mary F.

Wolf, George

Inhaltsverzeichnis

1;Front Cover;1
2;Chemical Induction of Cancer:
Structural Bases and Biological Mechanisms;4
3;Copyright Page;5
4;Table of
Contents;20
5;Dedication;6
6;General Plan;8
7;Foreword;10
8;Foreword to the First Edition;12
9;Preface;14
10;Acknowledgments;18
11;Chapter 1. Introduction;26
11.1;SELECTED READING FOR SECTION 1;31
11.2;1.1 Some Specific Bibliographic Tools of Chemical Oncology;32
12;Part I: Molecular Architecture and the Physical Bases of Molecular Forces;40
12.1;Chapter 2. Some Fundamentals of Organic Chemistry:Structural Concepts;42
12.1.1;2.1 Alkanes. Isomerism. Substitution Reactions. TheTetrahedral Carbon Atom;42
12.1.2;2.2 Alkenes and Alkynes. Chemical Properties of Double and Triple Bonds;51
12.1.3;2.3 Some Important Functional Groups and Their Reactions;58
12.1.4;2.4 Benzene and the Aromatic Character;89
12.2;Chapter 3. The Nature of Intra- and Intermolecular Forces;113
12.2.1;3.1 The Nature of Valence;113
12.2.2;3.2 Resonance;180
12.2.3;3.3 Secondary Valence Forces;249
12.2.4;3.4 Parameters of Molecular Geometry and Stability;298
13;Part II: The Nature of Tumors.Concepts and Techniques of Testing Chemical Agents for Carcinogenic Activity;326
13.1;Chapter 4. General Characteristics of Tumors and the Testing of Carcinogens;328
13.1.1;4.1 General Characteristics of Tumors;328
13.1.2;4.2 Some Aspects of the Pathology of Induced Tumors;340
13.1.3;4.3 Testing Procedures;365
14;Author Index;492
15;Subject Index;501