Aref / Barbie Ex Vivo Engineering of the Tumor Microenvironment

1. Auflage 2016
ISBN: 978-3-319-45397-2
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 135 Seiten

Reihe: Medicine

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo . Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Zielgruppe

Research

Autoren/Hrsg.

Aref, Amir R.

Barbie, David

Inhaltsverzeichnis

1.Introduction to Ex Vivo Cancer Models.- 2.Patient-derived Xenografts in Oncology.- 3.Organoid Culture: Applications in Development and Cancer.- 4. Microfluidics and future of cancer diagnostics.- 5.Advancing techniques and insights in circulating tumor cell (CTC) research.- 6.The Cancer Secretome.- 7.An overview of the tumor microenvironments and future of cancer therapy.

Über Autor(innen)

Amir R. Aref, PhD, is Instructor, Dana-Farber Cancer Institute, Harvard Medical School.