Aref / Barbie Ex Vivo Engineering of the Tumor Microenvironment

1. Auflage 2016
ISBN: 978-3-319-45397-2
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 135 Seiten, eBook

Reihe: Cancer Drug Discovery and Development

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo . Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Zielgruppe

Research

Autoren/Hrsg.

Aref, Amir R.

Aref, Aamir

Barbie, David

Inhaltsverzeichnis

1.Introduction to Ex Vivo Cancer Models.- 2.Patient-derived Xenografts in Oncology.- 3.Organoid Culture: Applications in Development and Cancer.- 4. Microfluidics and future of cancer diagnostics.- 5.Advancing techniques and insights in circulating tumor cell (CTC) research.- 6.The Cancer Secretome.- 7.An overview of the tumor microenvironments and future of cancer therapy.

Über Autor(innen)

Amir R. Aref, PhD, is Instructor, Dana-Farber Cancer Institute, Harvard Medical School.