Ariëns Drug Design

Medicinal Chemistry: A Series of Monographs, Vol. 7
1. Auflage 2013
ISBN: 978-1-4832-1609-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 312 Seiten, Web PDF

Drug Design, Volume VII covers the design of agents such as blood substitutes, pesticides derived from insect pheromones, and herbicides related to the auxin-type plant hormones. The book discusses the design of artificial blood substitutes and auxin-type herbicides; the use of insect pheromones as a basis for the development of more effective selective pest control agents; and the development and application of new steric substituent parameters in drug design. The text also describes the use of computer technology in drug design. Pharmacologists, chemists, biochemists, and people involved in drug design and manufacture will find the book invaluable.

Autoren/Hrsg.

Ariëns, E. J.

Inhaltsverzeichnis

1;Front Cover;1
2;Drug Design;4
3;Copyright Page;5
4;Table of Contents;6
5;Preface;10
6;Contents of Other Volumes;12
7;Chapter 1. The Design of Artificial Blood Substitutes;18
7.1;I. Introduction;18
7.2;II. Constituents;21
7.3;III. Formulation of Artificial Blood Substitutes;48
7.4;IV. Preparation of Perfluorochemical-Type Artificial Blood Substitutes;49
7.5;V. Testing Procedures;54
7.6;VI. Biological Considerations;65
7.7;VII. Potential and Summary;70
7.8;ACKNOWLEDGMENTS;72
7.9;References;72
8;Chapter 2. Insect Pheromones as a Basis for the Development of More Effective Selective Pest Control Agents;76
8.1;I. Introduction;77
8.2;II. Terminology;78
8.3;III. Identification of Pheromones;81
8.4;IV. Sex Pheromones of Lepidoptera;84
8.5;V. Pheromones and Food Attractants of Termites;96
8.6;VI. Ant Trail Pheromones and Related Semiochemicals;105
8.7;VII. Application of Pheromones and Their Analogs in Pest Control;111
8.8;VIII. Prospects for Designing New Compounds with Pheromonal Activities (Parapheromones);119
8.9;References;122
9;Chapter 3. The Design of Auxin-Type Herbicides;132
9.1;I. Introduction;132
9.2;II. Natural Plant Growth Regulators;134
9.3;III. Synthetic Growth Regulators Related to Indole-3-acetic Acid;144
9.4;IV. Other Synthetic Auxins;148
9.5;References;168
10;Chapter 4. Development and Application of New Steric Substituent Parameters in Drug Design;182
10.1;I. Introduction;182
10.2;II. Development of the New Steric Parameters;187
10.3;III. Use of the New Steric Parameters;203
10.4;IV. Scope and Limitations;217
10.5;References;223
11;Chapter 5. Computer Technology in Drug Design;226
11.1;I. Introduction;226
11.2;II. Computer Intelligence Applied to Drug Design;240
11.3;III. Conclusion;286
11.4;Appendix;290
11.5;ACKNOWLEDGMENT;292
11.6;References;292
12;Index;296