Arya Aminoglycoside Antibiotics

From Chemical Biology to Drug Discovery
1. Auflage 2007
ISBN: 978-0-470-14966-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 336 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

Advances that open new avenues in developing aminoglycosideantibiotics
During the last twenty years, there have been numerous advances inthe understanding of the chemistry, biochemistry, and recognitionof aminoglycosides. This has led to the development of novelantibiotics and opened up new therapeutic targets for intervention.This is the first book to provide a complete overview of recentadvances in the field and explore their tremendous potential fordrug discovery and rational drug design. With chapters written byone or more leading experts in their specialty areas, the bookaddresses the chemistry, biology, and toxicology ofaminoglycosides.
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discoveryis a great resource for academic and industrial researchers in drugdesign and mechanism studies and for researchers studyingantibiotic resistance, antibiotic design and synthesis, and thediscovery of novel pharmaceuticals. It is also a valuable referencefor graduate students in pharmacy, pharmaceutical science,biophysics, medicinal chemistry, and chemical biology.

Autoren/Hrsg.

Arya, Dev P.

Inhaltsverzeichnis

Preface vii
Contributors ix
1. In the Beginning There Was Streptomycin 1
Julian Davies
2. The Biochemistry and Genetics of Aminoglycoside Producers 15
Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier
3. Mechanisms of Aminoglycoside Antibiotic Resistance 119
Tushar Shakya and Gerard D. Wright
4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside
Antibiotics 141
Jinhua Wang and Cheng-Wei Tom Chang
5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181
R. Andrew Marshall and Joseph D. Puglisi
6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides 209
Jiro Kondo and Eric Westhof
7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225
Dale Kling, Christine Chow, and Shahriar Mobashery
8. Metalloaminoglycosides: Chemistry and Biological Relevance 235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan
9. Adverse Effects of Aminoglycoside Therapy 255
Andra E. Talaska and Jochen Schacht
10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267
Lev Elson-Schwab and Yitzhak Tor
11. Novel Targets for Aminoglycosides 289
Dev P. Arya, Nicholas Shaw, and Hongjuan Xi
Index 315

Über Autor(innen)

Dev P. Arya is an Associate Professor of Chemistry and Director of the Laboratory of Medicinal Chemistry at Clemson University. He is a member of the ACS, and currently serves as the Program Chair of the Division of Carbohydrate Chemistry. His research interests lie in the development of nucleic acid targeted drugs.