Bach / Good Clinical Immunobiology

1. Auflage 2014
ISBN: 978-1-4832-1632-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 1, 310 Seiten, Web PDF

Reihe: Clinical Immunobiology

Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Autoren/Hrsg.

Bach, Fritz H.

Good, Robert A.

Inhaltsverzeichnis

1;Front Cover;1
2;Clinical Immunobiology;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;12
6;Preface;14
7;Chapter 1. Structure-Function Relations in the Lymphoid System;16
7.1;I. Introduction;16
7.2;II. The Two-Component Concept;17
7.3;III. Development of B and T Cells;19
7.4;IV. Major Function of T Cells;19
7.5;V. Location and Nature of T Cells;20
7.6;VI. Distribution of T Cells;21
7.7;VII. The Nature and Distribution of B Cells;22
7.8;VIII. Development and Structure of the Thymus;24
7.9;IX. Functions of the Thymus;26
7.10;X. T-Cell Markers;28
7.11;XI. B-Cell Markers;30
7.12;XII. Structure and Function of the Bursa;31
7.13;XIII. The Bursal Equivalent;33
7.14;XIV. T-Cell–B-Cell Interactions;35
7.15;XV. Involution of the Immunological Systems;36
7.16;XVI. Immunodeficiency Diseases of Man in Light of the Differentiation of T and B Cells;37
7.17;XVII. The Crucial Experiments of Nature;38
7.18;References;41
8;Chapter 2. The Immunoglobulins;44
8.1;I. Introduction;44
8.2;II. Methods of Study;45
8.3;III. Problems of Heterogeneity;48
8.4;IV. Nomenclature;49
8.5;V. Antigenic Markers;51
8.6;VI. Gross Structural Relations;53
8.7;VII. Metabolism and Distribution of the Immunoglobulins;54
8.8;VIII. Function of Immunoglobulins and Structure-Function Relationships;56
8.9;IX. Cell Surface Immunoglobulins and Receptors;59
8.10;X. Phylogeny and Ontogeny;60
8.11;XI. Conclusion;61
9;Chapter 3. Cellular Immunity;62
9.1;I. Introduction;63
9.2;II. Some Definitions and the Ingredients of the Reaction;64
9.3;III. Cellular Immunity—A Basis for Immunological Homeostasis;66
9.4;IV. Immunological Surveillance and Tumor Espionage;67
9.5;V. Microbial Parasitism and Self +x Linkage—An Invitation to Autoimmunity;67
9.6;VI. Mechanisms of Cellular Immunity—in Vivo Expressions;69
9.7;VII. In Vitro Correlates of Cellular Immunity and Their Mediators;74
9.8;VIII. In Vivo Realities—The Scope of Cellular Immunity;78
9.9;IX. Immunological Amnesia—The Price of Immunosuppression;83
9.10;X. Deciphering the Language of Cells;84
9.11;XI. Cellular Ecology—Waste Disposal and the Loss of Immunological Virginity;85
9.12;XII. Cries of Relevance and Immunological Reconstitution;86
9.13;XIII. Conclusion;88
9.14;References;88
10;Chapter 4. Transplantation Immunology;90
10.1;I. Introduction;91
10.2;II. Mechanisms of Rejection;93
10.3;III. Physiological Consequences of Classic Rejection;102
10.4;IV. Immunosuppression;104
10.5;V. Changing Host-Graft Relationships;110
10.6;VI. Graft Pretreatment;120
10.7;VII. Histocompatibility Typing in Patients;122
10.8;VIII. Is Clinical Organ Transplantation Practical?;125
10.9;References;126
11;Chapter 5. Immunological Tolerance;128
11.1;I. Introduction;128
11.2;II. Relevance to Medicine;130
11.3;III. T and B Lymphocytes;131
11.4;IV. Antibody Affinity;131
11.5;V. Protein Antigens;132
11.6;VI. Pneumococcal Polysaccharide;135
11.7;VII. Antigen-Binding Cells in Tolerant Animals;137
11.8;VIII. In Vitro Tests for Cell-Mediated Cytotoxicity;137
11.9;IX. Blocking and Unblocking Serum Factors;139
11.10;X. Induced Tolerance to Allogeneic Cells;140
11.11;XI. Chimerism;142
11.12;XII. Transplanted Organs;143
11.13;XIII. Viruses and Virus-Induced Tumors;144
11.14;XIV. Tolerance to Foreign Red Blood Cells;146
11.15;XV. Tolerance to Skin Sensitizers;147
11.16;XVI. T-Cell Control;147
11.17;XVII. Ontogeny of Immune Responsiveness;148
11.18;XVIII. Development of Autoimmunity;150
11.19;XIX. In Vitro Studies of Tolerance and Underlying Mechanisms;151
11.20;References;153
12;Chapter 6. Inflammation;154
12.1;I. Introduction;154
12.2;II. Vascular Phase;155
12.3;III. Cellular Phase;157
12.4;IV. Lymphatics;159
12.5;V. Mediators;160
12.6;VI. Control of Inflammation;166
12.7;VII. Chronic Inflammation;168
12.8;VIII. Conclusion;169
12.9;References;170
13;Chapter 7. Fundamental Immunogenetics—Their Application to Histocompatibility;172
13.1;I. Introduction;172
13.2;II. Basic Genetics;174
13.3;III. Genes and Antigens;177
13.4;IV. Transplantation Genetics in the Mouse;179
13.5;V. Histocompatibility in Man;183
13.6;VI. Addendum;192
14;Chapter 8. Humoral Amplification Systems in Inflammation;194
14.1;I. Introduction;194
14.2;II. Complement;195
14.3;III. Kinin-Generating System;201
14.4;IV. Concluding Comments;205
14.5;References;207
15;Chapter 9. Immunosuppression;208
15.1;Introduction;208
15.2;I. Agents or Methods That Do Not Discriminate for Lymphocytes;211
15.3;II. Agents That Discriminate for Lymphocytes;215
15.4;III. Agents That Discriminate for Macrophages;217
15.5;IV. Agents That Discriminate between Lymphocyte Subpopulations;219
15.6;V. Agents That Discriminate for Specific Reactive Lymphocyte Clones;227
15.7;Miscellaneous Comments;229
15.8;References;230
16;Chapter 10. Tumor Immunology;234
16.1;I. Introduction;234
16.2;II. Critical Demonstration of Specific Defense Reactions against Experimental Tumors;236
16.3;III. Tumor-Associated Antigens in Virus-Induced Experimental Neoplasms;238
16.4;IV. In Vitro Approaches;240
16.5;V. Escapes;244
16.6;VI. Studies on Human Tumors;249
16.7;VII. Etiological Clues;253
16.8;References;254
17;Chapter 11. Allergy;258
17.1;I. Introduction;258
17.2;II. The Target Cells;260
17.3;III. The Antibodies;262
17.4;IV. The Allergens;266
17.5;V. Mediators;267
17.6;VI. The Interaction between Cell-Bound IgE and Allergen;270
17.7;VII. Mechanism of Mediator Release by the IgE-Allergen Interaction;270
17.8;VIII. The Relation of Intrinsic Asthma to the Allergic Response;273
17.9;IX. The Clinical Diagnosis of Allergic Diseases;275
17.10;X. The Pharmacological Therapy of Allergic Diseases;277
17.11;XI. The Immunological Therapy of Allergic Diseases;278
17.12;References;283
18;Chapter 12. Immunological Deficiency Disease;286
18.1;I. Introduction;286
18.2;II. Severe Combined Immunodeficiency;287
18.3;III. Infantile X-Linked Agammaglobulinemia;291
18.4;IV. Transient Hypogammaglobulinemia of Infancy;294
18.5;V. Selective Immunoglobulin Deficiencies;296
18.6;VI. X-Linked Immunodeficiency with Hyper-IgM;297
18.7;VII. Congenital Thymic Aplasia (DiGeorge's Syndrome);298
18.8;VIII. Episodic Lymphopenia with Lymphocytotoxin;299
18.9;IX. Wiskott-Aldrich Syndrome;300
18.10;X. Hereditary Ataxia-Telangiectasia;300
18.11;XI. Immunodeficiency with Normal or Hyperimmunoglobulinemia;301
18.12;XII. Immunodeficiency with Short-Limbed Dwarfism;301
18.13;XIII. Immunodeficiency with Thymoma;301
18.14;XIV. Common, Variable, Unclassifiable Immunodeficiency;302
18.15;XV. Secondary Defects in Immunity;303
18.16;XVI. Summary;304
18.17;References;304
19;SUBJECT INDEX;306