Bach / Good Clinical Immunobiology

1. Auflage 2014
ISBN: 978-1-4832-1635-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 4, 222 Seiten, Web PDF

Reihe: Clinical Immunobiology

Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called 'proliferative and cytotoxic responses'. The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

Autoren/Hrsg.

Bach, Fritz H.

Good, Robert A.

Inhaltsverzeichnis

1;Front Cover
;1
2;Clinical Immunobiology;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;12
6;Preface;16
7;Contents of Previous Volumes;20
8;Chapter 1. General Orientation of Human Lymphocyte Subpopulations;26
8.1;I. Introduction;27
8.2;II. Cytoplasmic Immunoglobulin;30
8.3;III. Membrane Immunoglobulin;31
8.4;IV. la System;34
8.5;V. Epstein-Barr Virus (EBV) Receptor;37
8.6;VI. Complement Receptors;38
8.7;VII. Receptors for Fc Region of Immunoglobulins;39
8.8;VIII. Enzymatic Markers;42
8.9;IX. Receptors for Peanut Agglutinin;43
8.10;X. Erythrocyte Receptors;44
8.11;XI Surface Antigens of Lymphocyte Subpopulations Defined by Monoclonal Antibodies;46
8.12;XII. Relationship between Ty Cells and Monocytes;51
8.13;XIII. Distinction of Lymphocytes from Monocytes;53
8.14;XIV. The Third-Cell Population or Unclassified Lymphoid Cells;54
8.15;XV. Summary;55
8.16;References;55
9;Chapter 2. Lymphocyte Membrane Complement Receptors;58
9.1;I. Introduction;58
9.2;II. Methods for Detection of C Receptors;62
9.3;III. Expression of C Receptors and Other Surface Markers on Normaland Leukemic Human Lymphocytes;65
9.4;IV. Interpretation and Significance;67
9.5;References;70
10;Chapter 3. Regulatory Human T-Cell Subpopulations Defined by Receptors for IgG or IgM;72
10.1;I. Introduction;72
10.2;II. Enumeration and Isolation of T.M and T.G Cells;73
10.3;III. Morphology of T.M and T.G Cells;74
10.4;IV. Tissue Distribution of T.M and T.G Cells;75
10.5;V. Functional Analysis of T.M and T.G Cells;75
10.6;VI. Clinical Relevance of T.M and T.G Subpopulations;77
10.7;Selected Reading;78
10.8;Addendum;78
11;Chapter 4. Mitogens;80
11.1;I. Introduction;80
11.2;II. Fundamentals of Lectin-Induced Mitogenesis;82
11.3;III. Procedure for Determining in Vitro Lectin-induced Activation of Lymphocytes;87
11.4;IV. Clinical Usefulness of Lectins;90
11.5;General Reading References;97
12;Chapter 5. Natural Killer Cells and Cells Mediating Antibody-Dependent Cytotoxicity against Tumors;98
12.1;I. Introduction;98
12.2;II. Methods;99
12.3;III. Characteristics of NK Cells and Their Relationship to K Cells;102
12.4;IV. Specificity of Natural Cytotoxicity;104
12.5;V. Factors Affecting Levels of NK and K Cell Activities;107
12.6;VI. Possible Clinical Significance of These Effector Cells;109
12.7;References;111
13;Chapter 6. Regulation of the Immune System by Lymphocyte Sets: Analysis in Animal Models;114
13.1;I. General Considerations;114
13.2;II. Analysis in the Mouse;116
13.3;III. Conclusions;120
13.4;Selected References;122
14;Chapter 7. The Serology of HLA-A, -B, and -C;124
14.1;I. Introduction;124
14.2;II. Experimental Methods and Findings;125
14.3;III. Conclusions;134
14.4;References;136
15;Chapter 8. The Serology of HLA-DR;138
15.1;I. Introduction;138
15.2;II. Technical Considerations;139
15.3;III. Results;143
15.4;IV. Discussion;145
15.5;References;146
16;Chapter 9. Cellular Immunogenetics—Definition of HLA-D Region Encoded Antigens by T Lymphocyte Reactivities;148
16.1;I. Introduction;149
16.2;II. Mixed Leukocyte Culture with Homozygous Typing Cells;152
16.3;III. Primed LD-Typing (PLT);157
16.4;IV. General Discussion;166
16.5;References;167
17;Chapter 10. Cell-Mediated Lympholysis;168
17.1;I. Introduction;168
17.2;II. Terminology;170
17.3;III. Technique;171
17.4;V. Genetic Control of CML;173
17.5;VI. Cell-Mediated Lympholysis Typing;176
17.6;VII. Preliminary Information from CML Typing Experiments;182
17.7;VIII. Future Prospects;183
17.8;Suggested Reading List;185
18;Chapter 11. HLA and Graft Survival;186
18.1;I. Introduction;186
18.2;II. Methodology;189
18.3;III. Results;191
18.4;References;196
19;Chapter 12. HLA and Disease;198
19.1;I. Introduction;198
19.2;II. Methods;199
19.3;III
. Relationships between HLA and Diseases;200
19.4;IV. Disease Heterogeneity;201
19.5;V. Inheritance of Disease Susceptibility and Resistance;202
19.6;VI. Mechanisms that Can Explain the Associations;204
19.7;VII. Diagnostic and Prognostic Value;205
19.8;Acknowledgments;206
19.9;Key References;206
20;Chapter 13. Other Markers in the HLA Linkage Group;208
20.1;I. Introduction;208
20.2;II. Genetic Considerations;210
20.3;III. Other Markers in the HLA Linkage Group;211
20.4;IV. Complement Components;212
20.5;V. Intracellular Enzymes;216
20.6;VI. Concluding Remarks;218
20.7;Selected References;219
21;Index;220