Bacq Fundamentals of Biochemical Pharmacology

1. Auflage 2013
ISBN: 978-1-4831-5759-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 674 Seiten, Web PDF

Fundamentals of Biochemical Pharmacology is a basic introduction to the fundamental aspects of pharmacology. It explains the molecular aspects of drugs, as well as the different biochemical systems and cellular strategies that they cause. The book is divided into two sections, the first of which covers physiochemical methods, histological methods, and physiological methods. The second section covers biochemical lesions; functions of subcellular structures; transfer of ions and molecules across cellular membrane; pharmacokinetics; drug receptor interactions; effects of drugs on structure; biosynthesis; catabolism; and biotransformation of drugs. The book is a good reference for pharmacology students who are learning about the the basic underlying concepts of biochemical pharmacology. It will also appeal to researchers with a background in chemistry, biochemistry, biology, microbiology, botany, or zoology.

Autoren/Hrsg.

Bacq, Z. M.

Inhaltsverzeichnis

1;Front Cover;1
2;Fundamentals of Biochemical Pharmacology;4
3;Copyright Page;5
4;Table of Contents;6
5;Dedication;3
6;PREFACE;10
7;LIST OF AUTHORS;14
8;SECTION A: OUTLINES OF METHODS;16
8.1;Chapter 1 Introduction to optical methods;18
8.1.1;1.1. INTRODUCTION;18
8.1.2;1.2. ANALYTICAL APPLICATION OF THE ELECTROMAGNETIC SPECTRUM;20
8.1.3;1.3. SPECTROSCOPIC METHODS;21
8.1.4;SELECTED READINGS AND REFERENCES;27
8.2;Chapter 2. Electronic and nuclear magnetic resonances;28
8.2.1;2.1. PRINCIPLES;28
8.2.2;2.2. APPARATUS;29
8.2.3;2.3. ELECTRONIC PARAMAGNETIC RESONANCE;29
8.2.4;2.4. NUCLEAR MAGNETIC RESONANCE;31
8.2.5;SELECTED READINGS AND REFERENCES;34
8.3;Chapter 3. Mass spectrometry;36
8.3.1;3.1. PRINCIPLES OF MASS SPECTROMETRY AND COMBINED GAS CHROMATOGRAPHY-MASS SPECTROMETRY;36
8.3.2;3.2. MASS SPECTROMETRIC TECHNIQUES AND THEIR APPLICATIONS;38
8.3.3;SELECTED READINGS AND REFERENCES;43
8.4;Chapter 4. Isotopic methods and activation analysis;44
8.4.1;4.1. FUNDAMENTALS;44
8.4.2;4.2. ISOTOPIC METHODS(3,15);44
8.4.3;4.3. ACTIVATION ANALYSIS;48
8.4.4;4.4. SAFETY PRECAUTIONS;48
8.4.5;SELECTED READINGS AND REFERENCES;48
8.5;Chapter 5. Isolation and purification procedures;50
8.5.1;5.1. CHROMATOGRAPHY;50
8.5.2;5.2. ELECTROPHORESIS;59
8.5.3;SELECTED READINGS AND REFERENCES;64
8.6;Chapter 6. Immunochemistry and radioimmunochemistry;66
8.6.1;6.1. INTRODUCTION;66
8.6.2;6.2. CONDITIONS NECESSARY FOR IMMUNOASSAY;66
8.6.3;6.3. IMMUNODIFFUSION AND IMMUNOELECTROPHORESIS;67
8.6.4;6.4. COMPLEMENT FIXATION;68
8.6.5;6.5. PASSIVE HAEMAGGLUTINATION;68
8.6.6;6.6. RADIOIMMUNOASSAY;69
8.6.7;SELECTED READINGS AND REFERENCES;73
8.7;Chapter 7. Introduction to enzyme kinetics;74
8.7.1;7.1. KINETICS OF CHEMICAL REACTIONS;74
8.7.2;7.2. KINETICS OF THE COMMON ENZYME-CATALYZED REACTIONS;78
8.7.3;7.3. EFFECT OF INHIBITORS;88
8.7.4;7.4. ALLOSTERIC REGULATIONS;97
8.7.5;SELECTED READINGS AND REFERENCES;101
8.8;Chapter 8. Centrifugation of subcellular components;102
8.8.1;8.1. HOMOGENIZATION;102
8.8.2;8.2. CENTRIFUGATION;104
8.8.3;SELECTED READINGS AND REFERENCES;111
8.9;Chapter 9. Electron microscopy;112
8.9.1;SELECTED READINGS AND REFERENCES;115
8.10;Chapter 10. Histoautoradiography;120
8.10.1;10.1. INTRODUCTION;120
8.10.2;10.2. NUCLEAR EMULSIONS AND ISOTOPES;121
8.10.3;10.3. WHOLE BODY AUTORADIOGRAPHY;122
8.10.4;10.4. ORGAN, TISSUE AND CELL AUTORADIOGRAPHY;122
8.10.5;10.5. HIGH-RESOLUTION AUTORADIOGRAPHY;123
8.10.6;10.6. AUTORADIOGRAPHY WITH THE ELECTRON MICROSCOPE;124
8.10.7;SELECTED READINGS AND REFERENCES;124
8.11;Chapter 11. Biochemical and pharmacological aspects of histochemistry;130
8.11.1;11.1. CHOLINESTERASES;130
8.11.2;11.2. OTHER ENZYMES;131
8.11.3;11.3 NUCLEIC ACIDS;131
8.11.4;11.4. BIOGENIC AMINES;131
8.11.5;SELECTED READINGS AND REFERENCES;135
8.12;Chapter 12. Animals and isolated organs;138
8.12.1;12.1. INTRODUCTION;138
8.12.2;12.2. ADVANTAGES OF PHYSIOLOGICAL TECHNIQUES;139
8.12.3;12.3. ALL-OR-NONE EFFECTS; GRADED RESPONSES;141
8.12.4;SELECTED READINGS AND REFERENCES;142
8.13;Chapter 13. Electrophysiological methods;144
8.13.1;13.1. ELECTRICAL ACTIVITY OF THE NERVOUS SYSTEM;144
8.13.2;13.2. HEART POTENTIALS;150
8.13.3;13.3. ELECTROMYOGRAPHY;151
8.13.4;13.4. SKIN POTENTIALS;152
8.13.5;SELECTED READINGS AND REFERENCES;152
8.14;Chapter 14. Behavioural techniques;154
8.14.1;14.1. GENERAL MOTOR ACTIVITY AND COMPLEX REFLEX TESTS;155
8.14.2;14.2. CONDITIONING TECHNIQUES;156
8.14.3;SELECTED READINGS AND REFERENCES;158
9;SECTION B: BIOCHEMICAL PHARMACOLOGY;160
9.1;Chapter 1. The Concept of the Biochemical Lesion;162
9.1.1;1.1. HISTORICAL DEVELOPMENT AND CLASSIFICATION;162
9.1.2;1.2. CLASSICAL CASES;163
9.1.3;1.3. THE ANALOGUES;165
9.1.4;SELECTED READINGS AND REFERENCES;165
9.2;Chapter 2. Functions of Subcellular Structures;166
9.2.1;2.1. BACTERIAL WALLS AND MEMBRANES;166
9.2.2;2.2. MITOCHONDRIA;176
9.2.3;2.3. DRUGS AND LYSOSOMES;203
9.2.4;SELECTED READINGS AND REFERENCES;211
9.3;Chapter 3. Transfer of Ions and Molecules Across Cellular Membranes;212
9.3.1;3.1. INTRODUCTION;212
9.3.2;3.2. ACTIVE TRANSPORT;213
9.3.3;3.3. MECHANISMS OF MEMBRANE PERMEATION;222
9.3.4;3.4. CONCLUSIONS;228
9.3.5;SELECTED READINGS AND REFERENCES;229
9.4;Chapter 4. Pharmacokinetics;230
9.4.1;4.1. INTRODUCTION;230
9.4.2;4.2. QUANTITATIVE ASPECTS OF MEMBRANE PERMEABILITY;232
9.4.3;4.3. INTRAVASCULAR ADMINISTRATION OF DRUGS;233
9.4.4;4.4. EXTRAVASCULAR ADMINISTRATION OF DRUGS;237
9.4.5;4.5. MULTIPLE DOSES AND DRUG ACCUMULATION;241
9.4.6;4.6. MULTICOMPARTMENT SYSTEMS;243
9.4.7;SELECTED READINGS AND REFERENCES;246
9.5;Chapter 5. Synaptic Vesicles, Specific Granules, Autopharmacology;248
9.5.1;5.1. CHOLINERGIC TRANSMISSIONS;248
9.5.2;5.2. ADRENERGIC TRANSMISSION;282
9.5.3;5.3. INDOLEALKYLAMINES;337
9.5.4;5.4. HISTAMINE;357
9.5.5;5.5. PROSTAGLANDINS;361
9.5.6;5.6. POLYPEPTIDES;371
9.6;Chapter 6. Drug-receptor Interactions;400
9.6.1;6.1. INTRODUCTION;400
9.6.2;6.2. QUANTITATIVE ASPECTS OF DRUG-RECEPTOR REACTIONS;403
9.6.3;6.3. AFFINITY AND INTRINSIC ACTIVITY;419
9.6.4;6.4. DRUG-RECEPTOR BINDING FORCES;427
9.6.5;6.5. pH AND DRUG-RECEPTOR REACTION;428
9.6.6;6.6. STRUCTURE-ACTION RELATIONSHIP;431
9.6.7;6.7. CONCLUDING REMARKS;441
9.6.8;SELECTED READINGS AND REFERENCES;442
9.7;Chapter 7. Chelating Agents;444
9.7.1;SELECTED READINGS AND REFERENCES;448
9.8;Chapter 8. Effects of Drugs on Structure, Biosynthesis and Catabolism of Nucleic Acids, Proteins, Carbohydrates and Lipids;450
9.8.1;8.1. NUCLEIC ACIDS AND PROTEINS;450
9.8.2;8.2. CARBOHYDRATES;567
9.8.3;8.3. DRUGS ACTING ON BLOOD LIPIDS;590
9.8.4;SELECTED READINGS AND REFERENCES;602
9.9;Chapter 9. Biotransformation of Drugs;604
9.9.1;9.1. INTRODUCTION;604
9.9.2;9.2. PATHWAYS OF DRUG BIOTRANSFORMATION;604
9.9.3;9.3. MECHANISMS OF DRUG OXIDATIONBY HEPATIC MICROSOMES;620
9.9.4;9.4. INDUCTION OF MICROSOMAL ENZYMES;625
9.9.5;9.5. FACTORS THAT INFLUENCE THE METABOLISM OF DRUGS BY MICROSOMAL ENZYMES;637
9.9.6;9.6. INHIBITION OF HEPATIC MICROSOMAL DRUG METABOLISM;642
9.9.7;SELECTED READINGS AND REFERENCES;644
9.10;Chapter 10. Pharmacogenetics;646
9.10.1;10.1. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY;646
9.10.2;10.2. ABNORMAL HAEMOGLOBINS;648
9.10.3;10.3. ACETOPHENETIDINE-INDUCED METHAEMOGLOBINAEMIA;648
9.10.4;10.4. POLYMORPHISM OF PSEUDOCHOLINESTERASE;649
9.10.5;10.5. VARIATION IN INH ACETYLATION;650
9.10.6;10.6. DIFFERENT HUMAN LIVER ALCOHOL DEHYDROGENASES;652
9.10.7;10.7. GENETIC VARIATION OF THE RESPONSE TO GLUCOCORTICOIDS;652
9.10.8;10.8. TASTE THRESHOLDS OF THIOUREA DERIVATIVES;653
9.10.9;10.9. RESISTANCE TO WARFARIN;653
9.10.10;10.10. DIFFERING DRUG RESPONSES IN ANIMALS;654
9.10.11;SELECTED READINGS AND REFERENCES;655
9.11;Chapter 11. Comparative Pharmacology;656
9.11.1;SELECTED READINGS AND REFERENCES;660
10;INDEX;662