Bacq Fundamentals of Biochemical Pharmacology

Pergamon International Library of Science, Technology, Engineering and Social Studies
1. Auflage 2014
ISBN: 978-1-4831-8162-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 674 Seiten, Web PDF

Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .

Autoren/Hrsg.

Bacq, Z. M.

Inhaltsverzeichnis

1;Front Cover;1
2;Fundamentals of Biochemical Pharmacology;4
3;Copyright Page;5
4;Table of Contents;6
5;Preface;10
6;List of Authors;14
7;Section A: OUTLINES OF METHODS;16
7.1;Chapter 1. Introduction to Optical Methods;18
7.1.1;1.1. INTRODUCTION;18
7.1.2;1.2. ANALYTICAL APPLICATION OF THE ELECTROMAGNETIC SPECTRUM;20
7.1.3;1.3. SPECTROSCOPIC METHODS;21
7.1.4;SELECTED READINGS AND REFERENCES;27
7.2;Chapter 2. Electronic and Nuclear Magnetic Resonances;28
7.2.1;2.2. APPARATUS;29
7.2.2;2.1. PRINCIPLES;28
7.2.3;2.3. ELECTRONIC PARAMAGNETIC RESONANCE;29
7.2.4;2.4. NUCLEAR MAGNETIC RESONANCE;31
7.2.5;SELECTED READINGS AND REFERENCES;34
7.3;Chapter 3. Mass Spectrometry;36
7.3.1;3.1. PRINCIPLES OF MASS SPECTROMETRY AND COMBINED GAS CHROMATOGRAPHY-MASS SPECTROMETRY;36
7.3.2;3.2. MASS SPECTROMETRIC TECHNIQUES AND THEIR APPLICATIONS;38
7.3.3;SELECTED READINGS AND REFERENCES;43
7.4;Chapter 4. Isotopie Methods and Activation Analysis;44
7.4.1;4.1. FUNDAMENTALS;44
7.4.2;4.2. ISOTOPIC METHODS;44
7.4.3;4.3. ACTIVATION ANALYSIS;48
7.4.4;4,4. SAFETY PRECAUTIONS;48
7.4.5;SELECTED READINGS AND REFERENCES;48
7.5;Chapter 5. Isolation and Purification Procedures;50
7.5.1;5.1. CHROMATOGRAPHY;50
7.5.2;5.2. ELECTROPHORESIS;59
7.5.3;SELECTED READINGS AND REFERENCES;64
7.6;Chapter 6. Immunochemistry and Radioimmunochemistry;66
7.6.1;6.1. INTRODUCTION;66
7.6.2;6.2. CONDITIONS NECESSARY FOR IMMUNOASSAY;66
7.6.3;6.3. IMMUNODIFFUSION AND IMMUNOELECTROPHORESIS;67
7.6.4;6.4 COMPLEMENT FIXATION;68
7.6.5;6.5. PASSIVE HAEMAGGLUTINATION;68
7.6.6;6.6. RADIOIMMUNOASSAY;69
7.6.7;SELECTED READINGS AND REFERENCES;73
7.7;Chapter 7. Introduction to Enzyme Kinetics;74
7.7.1;7.1. KINETICS OF CHEMICAL REACTIONS;74
7.7.2;7.2. KINETICS OF THE COMMON ENZYME-CATALYZED REACTIONS;78
7.7.3;7.3. EFFECT OF INHIBITORS;88
7.7.4;7.4. ALLOSTERIC REGULATIONS;97
7.7.5;SELECTED READINGS AND REFERENCES;101
7.8;Chapter 8. Centrifugation of Subcellular Components;102
7.8.1;8.1. HOMOGENIZATION;102
7.8.2;8.2. CENTRIFUGATION;104
7.8.3;SELECTED READINGS AND REFERENCES;111
7.9;Chapter 9. Electron Microscopy;112
7.9.1;SELECTED READINGS AND REFERENCES;115
7.10;Chapter 10. Histoautoradiography;120
7.10.1;10.1. INTRODUCTION;120
7.10.2;10.2. NUCLEAR EMULSIONS AND ISOTOPES;121
7.10.3;10.3. WHOLE BODY AUTORADIOGRAPHY;122
7.10.4;10.4. ORGAN, TISSUE AND CELL AUTORADIOGRAPHY;122
7.10.5;10.5. HIGH-RESOLUTION AUTORADIOGRAPHY;123
7.10.6;10.6. AUTORADIOGRAPHY WITH THE ELECTRON MICROSCOPE;124
7.10.7;SELECTED READINGS AND REFERENCES;124
7.11;Chapter 11. Biochemical and Pharmacological Aspects of Histochemistry;130
7.11.1;11.1. CHOLINESTERASES;130
7.11.2;11.2. OTHER ENZYMES;131
7.11.3;11.3. NUCLEIC ACIDS;131
7.11.4;11.4. BIOGENIC AMINES;131
7.11.5;SELECTED READINGS AND REFERENCES;135
7.12;Chapter 12.
Animals and Isolated Organs;138
7.12.1;12.1. INTRODUCTION;138
7.12.2;12.2. ADVANTAGES OF PHYSIOLOGICAL TECHNIQUES;139
7.12.3;12.3. ALL-OR-NONE EFFECTS; GRADED RESPONSES;141
7.12.4;SELECTED READINGS AND REFERENCES;142
7.13;Chapter 13.
Electrophysiological Methods;144
7.13.1;13.1. ELECTRICAL ACTIVITY OF THE NERVOUS SYSTEM;144
7.13.2;13.2. HEART POTENTIALS;150
7.13.3;13.3. ELECTROMYOGRAPHY;151
7.13.4;13.4. SKIN POTENTIALS;152
7.13.5;SELECTED READINGS AND REFERENCES;152
7.14;Chapter 14.
Behavioural Techniques;154
7.14.1;14.1. GENERAL MOTOR ACTIVITY AND COMPLEX REFLEX TESTS;155
7.14.2;14.2. CONDITIONING TECHNIQUES;156
7.14.3;SELECTED READINGS AND REFERENCES;158
8;Section B:
BIOCHEMICAL PHARMACOLOGY;160
8.1;Chapter 1.
The Concept of the Biochemical Lesion;162
8.1.1;1.1. HISTORICAL DEVELOPMENT AND CLASSIFICATION;162
8.1.2;1.2. CLASSICAL CASES;163
8.1.3;1.3. THE ANALOGUES;165
8.1.4;SELECTED READINGS AND REFERENCES;165
8.2;Chapter 2.
Functions of Subcellular Structures;166
8.2.1;2.2. MITOCHONDRIA;176
8.2.2;2.3. DRUGS AND LYSOSOMES;203
8.2.3;SELECTED READINGS AND REFERENCES;211
8.3;Chapter 3. Transfer of Ions and Molecules Across Cellular Membranes;212
8.3.1;3.1. INTRODUCTION;212
8.3.2;3.2. ACTIVE TRANSPORT;213
8.3.3;3.3. MECHANISMS OF MEMBRANE PERMEATION;222
8.3.4;3.4. CONCLUSIONS;228
8.3.5;SELECTED READINGS AND REFERENCES;229
8.4;Chapter 4.
Pharmacokinetics;230
8.4.1;4.1. INTRODUCTION;230
8.4.2;4.2. QUANTITATIVE ASPECTS OF MEMBRANE PERMEABILITY;232
8.4.3;4.3. INTRA VASCULAR ADMINISTRATION OF DRUGS;233
8.4.4;4.4. EXTRAVASCULAR ADMINISTRATION OF DRUGS;237
8.4.5;4.5. MULTIPLE DOSES AND DRUG ACCUMULATION;241
8.4.6;4.6. MULTICOMPARTMENT SYSTEMS;243
8.4.7;SELECTED READINGS AND REFERENCES;246
8.5;Chapter 5.
Synaptic Vesicles, Specific Granules, Autopharmacology;248
8.5.1;5.1. CHOLINERGIC TRANSMISSIONS;248
8.5.2;5.2. ADRENERGIC TRANSMISSION;282
8.5.3;5.3. INDOLEALKYLAMINES;337
8.5.4;5.4. HISTAMINE;357
8.5.5;5.5. PROSTAGLANDINS;361
8.5.6;5.6. POLYPEPTIDES;371
8.5.7;SELECTED READINGS AND REFERENCES;380
8.6;Chapter 6.
Drug-receptor Interactions;400
8.6.1;6.1. INTRODUCTION;400
8.6.2;6.2. QUANTITATIVE ASPECTS OF DRUG-RECEPTOR REACTIONS;403
8.6.3;6.3. AFFINITY AND INTRINSIC ACTIVITY;419
8.6.4;6.4. DRUG-RECEPTOR BINDING FORCES;427
8.6.5;6.5. pH AND DRUG-RECEPTOR REACTION;428
8.6.6;6.6. STRUCTURE-ACTION RELATIONSHIP;431
8.6.7;6.7. CONCLUDING REMARKS;441
8.6.8;SELECTED READINGS AND REFERENCES;442
8.7;Chapter 7.
Chelating Agents;444
8.7.1;SELECTED READINGS AND REFERENCES;448
8.8;Chapter 8. Effects of Drugs on Structure, Biosynthesis and Catabolism of Nucleic Acids, Proteins, Carbohydrates and Lipids;450
8.8.1;8.1. NUCLEIC ACIDS AND PROTEINS;450
8.8.2;8.2. CARBOHYDRATES;567
8.8.3;8.3. DRUGS ACTING ON BLOOD LIPIDS;590
8.8.4;SELECTED READINGS AND REFERENCES;602
8.9;Chapter 9.
Biotransformation of Drugs;604
8.9.1;9.1. INTRODUCTION;604
8.9.2;9.2. PATHWAYS OF DRUG BIOTRANSFORMATION;604
8.9.3;9.3. MECHANISMS OF DRUG OXIDATION BY HEPATIC MICROSOMES;620
8.9.4;9.4. INDUCTION OF MICROSOMAL ENZYMES;625
8.9.5;9.5. FACTORS THAT INFLUENCE THE METABOLISM OF DRUGS BY MICROSOMAL ENZYMES;637
8.9.6;9.6. INHIBITION OF HEPATIC MICROSOMAL DRUG METABOLISM;642
8.9.7;SELECTED READINGS AND REFERENCES;644
8.10;Chapter 10. Pharmacogenetics;646
8.10.1;10.1. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY;646
8.10.2;10.2. ABNORMAL HAEMOGLOBINS;648
8.10.3;10.3. ACETOPHENETIDINE-INDUCED METHAEMOGLOBINAEMIA;648
8.10.4;10.4. POLYMORPHISM OF PSEUDOCHOLINESTERASE;649
8.10.5;10.5. VARIATION IN INH ACETYLATION;650
8.10.6;10.6. DIFFERENT HUMAN LIVER ALCOHOL DEHYDROGENASES;652
8.10.7;10.7. GENETIC VARIATION OF THE RESPONSE TO GLUCOCORTICOIDS;652
8.10.8;10.8. TASTE THRESHOLDS OF THIOUREA DERIVATIVES;653
8.10.9;10.9. RESISTANCE TO WARFARIN;653
8.10.10;10.10. DIFFERING DRUG RESPONSES IN ANIMALS;654
8.10.11;SELECTED READINGS AND REFERENCES;655
8.11;Chapter 11.
Comparative Pharmacology;656
8.11.1;SELECTED READINGS AND REFERENCES;660
9;INDEX;662