Balajee DNA Repair and Human Disease

1. Auflage 2007
ISBN: 978-0-387-36802-3
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 161 Seiten

DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Autoren/Hrsg.

Balajee, Adayabalam

Inhaltsverzeichnis

1;CONTENTS;5
2;EDITOR;8
3;CONTRIBUTORS;8
4;PREFACE;10
5;Human Premature Aging Disorders and Dysfunction of DNA Repair;12
6;DNA Repair Aspects for RecQ Helicase Disorders;31
7;Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription;41
8;Roles of the BRCAl and BRCA2 Breast Gmcer Susceptibility Proteins in DNA Repair;58
9;Radiosensitivity of Cells Derived from Down Syndrome Patients: Is Defective DNA Repair Involved?;72
10;The Fanconi Anemia/BRCA Pathway. FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage;78
11;Is Ataxia Telangiectasia a Result of Impaired Coordination between DNA Repair and Cell Cycle Checkpoint Regulators?;93
12;Mechanisms of DNA Damage and Repair in Alzheimer Disease;109
13;Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing;125
14;Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients;139
15;Index;158