Barciszewski Decoding Aging and Neurodegeneration

The Role of Nucleic Acid Epigenetics
1. Auflage 2025
ISBN: 978-3-031-91072-2
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 403 Seiten

Reihe: RNA Technologies

This book focuses on the close relationship between aging and neurodegeneration. By highlighting the reversible nature of epigenetic changes, it provides a comprehensive overview of how these modifications can regulate gene expression without altering the DNA sequence, offering promising solutions for clinical intervention.

Aging induces a gradual decline in cerebral function, leading to cognitive impairment, memory loss, motor dysfunction, and eventually functional decline and death. It is accompanied by the decline of organismal functions induced by whole genome alterations leading to neurodegeneration. Epigenetic modifications, including chromatin modifications, DNA methylation, and changes in regulatory RNAs, have a major impact on neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
The chapters in this book address critical issues such as the contribution of epigenetic mechanisms to aging, the interaction between genetic and environmental factors in neurodegeneration, and the potential for epigenetic therapies to delay aging and mitigate disease progression.

This volume, part of the book series, is an invaluable resource for researchers and advanced students in genetics and neuroscience. It provides a deep understanding of the molecular basis of neurodegenerative diseases and offers innovative strategies to address the challenges of aging and neurodegeneration. 

Zielgruppe

Research

Autoren/Hrsg.

Barciszewski, Jan

Inhaltsverzeichnis

Chapter 1. Deciphering (Epigenetic) Mechanisms Behind Aging and Senescence Using Next-Generation Sequencing Technologies.- Chapter 2. Deciphering the Interplay: DNA Methylation Dynamics in Aging and Neurodegenerative Diseases.- Chapter 3. The Exposome, DNA Methylation, and Neurodegenerative Disorders.- Chapter 4. Regulation of RNA Transcriptomics During Ageing- and Neurodegeneration-Associated Cognitive Changes.- Chapter 5. DNA Methylation Control over Aging: a Focus on Repetitive Elements.- Chapter 6. DNA Methylation in a Systemic Framework for Healthy Aging and Longevity.- Chapter 7. Epigenetic Parameters as Potential Prognostic and Therapeutic Factors in Neurodegenerative Diseases.- Chapter 8. Unraveling Epigenetic Modifications in Glaucoma: Biomarkers and Therapeutic Targets.- Chapter 9. Unveiling the Crucial Role of R-Loops in Genome Instability and Neurological Disorders.- Chapter 10. Noncoding RNAs and RNA Epigenetics in Brain Aging.- Chapter 11. Long Noncoding RNAs: Emerging Players in Neurodegenerative Diseases.- Chapter 12. Genetic-Epigenetic Regulatory Mechanisms of Extrachromosomal Circular DNA: Evidence for a Role in Aging and Age-Related Neurodegenerative Disorders.- Chapter 13. Epigenetic Regulation Mediating Immunopathology in Parkinson’s Disease.- Chapter 14. Decoding the Involvement of miRNAs in Alzheimer's Disease: Focus on Neuroinflammation.- Chapter 15. Alzheimer’s Disease: Link to Aging and Epigenetics.- Chapter 16. Towards a Systematic Understanding of Epigenetic Contribution to Normal Aging and Alzheimer’s Disease.

Über Autor(innen)

Jan Barciszewski is Professor at Adam Mickiewicz University (AMU) in Poznan, Poland, and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland, where he has worked since 1974. He studied organic chemistry at the AMU. During his Ph.D. studies, he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine-specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s, he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents. He is also interested in circular RNAs biogenesis.