Baxevanis / Ouellette Bioinformatics

A Practical Guide to the Analysis of Genes and Proteins
2. Auflage 2004
ISBN: 978-0-471-46101-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 43, 504 Seiten, E-Book

Reihe: Methods of Biochemical Analysis

"In this book, Andy Baxevanis and Francis Ouellette . . . haveundertaken the difficult task of organizing the knowledge in thisfield in a logical progression and presenting it in a digestibleform. And they have done an excellent job. This fine text will makea major impact on biological research and, in turn, on progress inbiomedicine. We are all in their debt."
--Eric Lander from the Foreword
Reviews from the First Edition
"...provides a broad overview of the basic tools for sequenceanalysis ... For biologists approaching this subject for the firsttime, it will be a very useful handbook to keep on the shelf afterthe first reading, close to the computer."
--Nature Structural Biology
"...should be in the personal library of any biologist who usesthe Internet for the analysis of DNA and protein sequencedata."
--Science
"...a wonderful primer designed to navigate the novice throughthe intricacies of in scripto analysis ... The accomplished genesearcher will also find this book a useful addition to theirlibrary ... an excellent reference to the principles ofbioinformatics."
--Trends in Biochemical Sciences
This new edition of the highly successful Bioinformatics:A Practical Guide to the Analysis of Genes and Proteinsprovides a sound foundation of basic concepts, with practicaldiscussions and comparisons of both computational tools anddatabases relevant to biological research.
Equipping biologists with the modern tools necessary to solvepractical problems in sequence data analysis, the Second Editioncovers the broad spectrum of topics in bioinformatics, ranging fromInternet concepts to predictive algorithms used on sequence,structure, and expression data. With chapters written by experts inthe field, this up-to-date reference thoroughly covers vitalconcepts and is appropriate for both the novice and the experiencedpractitioner. Written in clear, simple language, the book isaccessible to users without an advanced mathematical or computerscience background. This new edition includes:
* All new end-of-chapter Web resources, bibliographies, andproblem sets
* Accompanying Web site containing the answers to the problems,as well as links to relevant Web resources
* New coverage of comparative genomics, large-scale genomeanalysis, sequence assembly, and expressed sequence tags
* A glossary of commonly used terms in bioinformatics andgenomics
Bioinformatics: A Practical Guide to the Analysis of Genesand Proteins, Second Edition is essential reading forresearchers, instructors, and students of all levels in molecularbiology and bioinformatics, as well as for investigators involvedin genomics, positional cloning, clinical research, andcomputational biology.

Autoren/Hrsg.

Baxevanis, Andreas D.

Ouellette, B. F. Francis

Inhaltsverzeichnis

Bioinformatics and the Internet (A. Baxevanis & B. Ouellette).
The NCBI Data Model (J. Ostell, et al.).
The GenBank Sequence Database (I. Karsch-Mizrachi & B.Ouellette).
Submitting DNA Sequences to the Databases (J. Kans & B.Ouellette).
Structure Databases (C. Hogue).
Genomic Mapping and Mapping Databases (P. White & T.Matise).
Information Retrieval from Biological Databases (A.Baxevanis).
Sequence Alignment and Database Searching (G. Schuler).
Multiple Sequence Alignment (G. Barton).
Predictive Methods Using DNA Sequences (A. Baxevanis).
Predictive Methods Using Protein Sequences (S. Banerjee-Basu& A. Baxevanis).
Expressed Sequence Tags (ESTs) (T. Wolfsberg & D.Landsman).
Sequence Assembly and Finishing Methods (R. Staden, etal.).
Phylogenetic Analysis (F. Brinkman & D. Leipe).
Comparative Genome Analysis (M. Galperin & E. Koonin).
Large-Scale Genome Analysis (P. Meltzer).
Using Perl to Facilitate Biological Analysis (L. Stein).

Über Autor(innen)

About the Editors
Dr. Baxevanis is Associate Director for Intramural Research, andDirector for Computational Genomics at the National Human GenomeResearch Institute, National Institutes of Health. He received hisBS in biological sciences from Cornell University in 1984 and hisPhD in the Department of Biology at The Johns Hopkins University in1991. His research focuses on protein structure-functionrelationships, positional cloning, and the development of newmethods for analysis of gene expression data. His accom-plishmentshave been recognized by the Bodossaki Foundation in Greece, whoawarded him their 1999 Academic Prize in Medicine andBiology.
Dr. Ouellette is Director of the Bioinformatics Core facility atthe Center for Molecular Medicine and Therapeutics, University ofBritish Columbia, and Director of the Bioinformatics Core facilityfor the Canadian Genetic Diseases Network. He held the position ofGenBank coordinator for the National Center for BiotechnologyInformation at the National Institutes of Health. He received hisPhD from the Department of Biology at McGill University in 1991,and is the founder and moderator of bionet.molbio.yeast, a Usenetdiscussion forum for the yeast genomics community.