Phylogenomics

An Introduction
Softcover Nachdruck of the original 1. Auflage 2017
ISBN: 978-3-319-85307-9
Verlag: Springer International Publishing

Buch, Englisch, 222 Seiten, Paperback, Format (B × H): 168 mm x 240 mm, Gewicht: 451 g

This unique textbook provides a clear and concise overview of the key principles of the complex field of phylogenomics, with a particular focus on sequencing technologies that are crucial to studying and understanding interrelations in evolutionary genomics. It includes chapters dedicated to the analysis of nucleotide sequences using assembling and alignment methods and also discusses the main strategies for phylogenetic studies, systematic errors and their correction. This highly readable textbook is intended for graduate students and young researchers with an interest in phylogenetics and evolutionary developmental biology.

Zielgruppe

Graduate

Autoren/Hrsg.

Bleidorn, Christoph

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

1. Genomes.- 01.1 Prokaryotes vs. Eukaryotes.- 01.2 Genome Structure.- 01.3 Genome Sizes.- 01.4 Human Genome and Ancient DNA (Neandertaler, Denisova).- 2. Genomes of Organelles.- 02.1 Mitochondria.- 02.2 Plastids.- 02.3 Outlook Obligate Endosymbionts.- 3. Transcriptomes.- 03.1 mRNA.- 03.2 Transcripts.- 03.3 Expression Level.- 03.4 Alternative Splicing.- 4. Sequencing Techniques.- 04.1 Sanger.- 04.2 Illumina.- 04.3 454.- 04.4 PacBio.- 04.5 Outlook Nanopore Sequencing.- 5. Genome Sequencing Strategies.- 05.1 Whole Genome Shotgun.- 05.2 RADseq.- 05.3 Target Enrichment.- 05.4 RNAseq.- 6. Assembly and Mapping.- 06.1 Assembling Strategies (kmer vs OLC).- 06.2 Data Quality and Filtering.- 06.3 Re-Sequencing and Mapping.- 06.4 De novo Assembly Genome.- 06.5 De novo Assembly Transcriptome.- 7. Locating Genes.- 07.1 Orthology vs. Paralogy.- 07.2 BLAST and Successors.- 07.3 Hidden Markov Profile.- 07.4 Ortholog Conjecture.- 8. Alignment.- 08.1 Alignment Strategies.- 08.2 Alignment Masking.- 9. Phylogenetic Analysis.- 09.1 Distance Measurements.- 09.2 Maximum Parsimony.- 09.3 Maximum Likelihood.- 09.4 Bayesian Inference.- 09.5 Supermatrix vs. Single Gene Analysis (Gene Trees vs. Species Trees).- 10. Systematic Errors in phylogenetic Analysis.- 10.1 Prediction: Evolutionary Models.- 10.2 Heterogenity Nucleotide/Amino Acid-Composition.- 10.3 Variation of substitution rate between the lines.- 10.4 Variation of substitution rate over time.- 10.5 New Approaches to Correct systematic Errors.- 11. Genome-wide Characteristics.- 11.1 Gene Order.- 11.2 Mobile Elements.- 11.3 microRNAs.- 11.4 Differences in the genetic code.- 12. Index.- 13. References

Über Autor(innen)

Prof. Dr. Christoph Bleidorn Georg-August-University Göttingen Johann-Friedrich-Blumenbach Institute for Zoology & Anthropology Animal Evolution and Biodiversity Göttingen, Germany [e-mail]