Bock / Goode Defining Optimal Immunotherapies for Type 1 Diabetes

1. Auflage 2008
ISBN: 978-0-470-69741-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 222 Seiten, E-Book

Reihe: Novartis Foundation Symposia

* This book is a comprehensive and up-to-date account of where westand in immunological strategies for preventing or treating type 1diabetes (T1D).
* Brings together contributions from the leaders in the arena ofclinical immunotherapy, not limited to the diabetes fieldexclusively, in order to delineate a road-map that would lead tofuture clinical trials.
* The book integrates information from human and animalstudies.
* The book considers T1D within the broader context of autoimmunedisease.
* The format contains several discussions, which address specificquestions and provides guidelines for future strategies andsolutions for discovering a cure.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

1. Michael Rutter
Introduction: whither gene-environment interactions?
2. Rudolf Uher
Gene-environment interaction: overcoming methodologicalchallenges
Discussion
3. Marco Battaglia, Cecilia Marino, Michel Maziade, MassimoMolteni and Francesca D'Amato
Gene-environment interaction and behavioural disorders: adevelopmental perspective based on endophenotypes
Discussion
4. Naomi R. Wray, William L. Coventry, Michael R. James,Grant W. Montgomery, Lindon J. Eaves and Nicholas G.Martin
Use of monozygotic twins to investigate the relationship between5HTTLPR genotype, depression and stressful life events: anapplication of Item Response Theory
Discussion
Appendix
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J. H. Penninx, Harriëtte Riese and Catharina A.Hartman
Role of gene-stress interactions in gene-findingstudies
Discussion
6. Kenneth A. Dodge
Practice and public policy in the era of gene-environmentinteractions
Discussion
7. Kristi B. Adamo and FrédériqueTesson
Gene-environment interaction and the metabolicsyndrome
Discussion
General discussion II
8. Stephen P. Robertson and RichiePoulton
Longitudinal studies of gene-environment interaction incommon diseases--good value for money?
Discussion
9. Kee-Seng Chia
Gene-environment interactions in breast cancer
Discussion
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz,Sarah Rowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches tounderstanding how gene-environment interactions work topredict susceptibility and outcomes of infections
Discussion
11. Steven R. Kleeberger and Hye-YounCho
Gene-environment interactions in environmental lungdiseases
Discussion
General discussion III
12. Fernando D. Martinez
Gene-environment interaction in complex diseases: asthmaas an illustrative case
Discussion
13. Michael Rutter
Conclusions: taking stock and looking ahead
Glossary
Index of contributors
Subject index