Bock / Goode Heart Failure

Molecules, Mechanisms and Therapeutic Targets
1. Auflage 2006
ISBN: 978-0-470-02932-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 302 Seiten, E-Book

Reihe: Novartis Foundation Symposia

Heart failure is the main cause of death and disability in theindustrialized world. There is a major need for novel therapeuticsfor prevention and reversal of cardiac pathology associated withheart failure and cardiac enlargement. Over recent years, dramaticprogress has been made in unravelling the cellular circuitryinvolved in cardiac failure, as well as in normal cardiac growth,development and apoptosis. This work has revealed new andunexpected therapeutic targets in the heart. In addition, advancesin understanding the role of stem cells in cardiac physiology havesuggested strategies for cardiac repair and regeneration oncethought impossible.
This book describes the work of leading investigators studyingthe basic mechanisms of cardiac growth, function and dysfunction.There are also exciting contributions from researchers developingnovel therapeutic strategies for cardiac disease. The uniquefeature is the discussions amongst the contributors, which alwaysreturn to the same basic problem: how can new data from biologicalstudies be used to design novel therapies for the treatment ofcardiac dysfunction following myocardial infarction, hypertensionand other disorders?
With its strong emphasis on translational research, this bookwill appeal to both scientists and clinicians interested indiminishing the impact of the current epidemic of cardiacdiseases.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

Introduction (Eric N. Olson).
Control of cardiac hypertrophy and heart failure by histoneacetylation/deacetylation (Eric N. Olson, Johannes Backs andTimothy A. McKinsey) .
Discussion.
A novel mechanism of mechanical stress-induced hypertrophy(Hiroshi Akazawa, Yunzeng Zou and Issei Komuro) .
Discussion.
Controlling cardiomyocyte survival (N. de Jonge, M. J.Goumans, Daan Lips, Rutger Hassink, Eva J. Vlug, Roy van der Meel,Christopher Donald Emmerson, Joppe Nijman, Leon de Windt and PieterA. Doevendans) .
Discussion.
Mechanisms of angiotensin II-dependent progression to heartfailure (Mona Nemer, Nassim Dali-Youcef, Hao Wang, Anne Ariesand Pierre Paradis) .
Discussion.
Alterations in myocardial gene expression as a basis forcardiomyopathies and heart failure (Matthew R. Taylor andMichael R. Bristow) .
Discussion.
Role of the insulin-like growth factor 1(IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediatingphysiological cardiac hypertrophy (Julie R. McMullen and SeigoIzumo).
Discussion.
Role of Akt in cardiac growth and metabolism(Anthony J.Muslin and Brian DeBosch).
Discussion.
Novel therapy for heart failure and exercise-induced ventriculartachycardia based on 'fixing' the leak in ryanodinereceptors (Andrew R. Marks).
Discussion.
General discussion I.
Phospholamban as a therapeutic modality in heart failure(Guoxiang Chu and Evangelia G. Kranias).
Discussion.
Sarcomere protein gene mutations and inherited heart disease: ab-cardiac myosin heavy chain mutation causing endocardialfibroelastosis and heart failure (Mitsuhiro Kamisago, Joachim P.Schmitt, Dennis McNamara, Christine Seidman and Jonathan G.Seidman).
Discussion.
The cardiomyocyte cell cycle (Pascal J. E. Lafontant andLoren J. Field).
Discussion.
Restoration of cardiac function with progenitor cells (CarmenUrbich, Lothar Rössig and Stefanie Dimmeler).
Discussion.
Signalling pathways in cardiac regeneration (Maria PaolaSantini, Nadine Winn and Nadia Rosenthal).
Discussion.
Beyond small molecule drugs for heart failure: prospects forgene therapy (Kenneth R. Chien).
Discussion.
Dual roles of telomerase in cardiac protection and repair(Michael D. Schneider).
Discussion.
Final general discussion.
Closing remarks: historical perspective (Arnold M.Katz).
Index of contributors.
Subject index.

Über Autor(innen)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.