Bock / Goode Immunological Tolerance
1. Auflage 2008
ISBN: 978-0-470-51553-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 248 Seiten, E-Book
Reihe: Novartis Foundation Symposium
ISBN: 978-0-470-51553-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Autoren/Hrsg.
Weitere Infos & Material
Introduction (Mitchison).
Mechanisms of peripheral T cell tolerance (L. Parijs, etal.).
B cell antigen receptor signalling in the balance of toleranceand immunity (Cirnall and FGoodnow).
General discussion I.
The study of self-tolerance using murine haemoglobin as a modelself antigen (Williams and Allen).
Tolerance and determinant hierarchy (Schnieder et al).
Molecular genetic studies in lymphocyte apoptosis and humanautoimmunity (Martin, et al.).
General discussion II.
A Role for CTLA-4-mediated inhibitory signals in peripheral TCell tolerance? (Allison, et al).
Antigen-specific CD4¯+ Tcells that survive after theinduction of peripheral tolerance possess an intrinsic lymphokineproduction defect (pape et al).
Antigen-specific tolerance induction and the immunotherapy ofexperimental autoimmunity disease (Anderton, et al.).
Quantitative and qualitative control of antigen receptorsignalling in tolerant B lymphocytes (Healy, et al.).
Tolerance induction with CD4 monoclonal antibodies (Waldmann etal).
Cross-presentation of self antigens to CD8¯+ Tcells:the balance between tolerance and autoimmunity (Kurts et al).
General discussion III.
Tolerance induction in mature T lymphocytes (Alferink, etal.).
T lymphocyte-mediated control of autoimmunity (E. Shevach, etal.).
Final General Discussion.
Indexes.
