Bock / Goode Signalling Networks in Cell Shape and Motility

1. Auflage 2005
ISBN: 978-0-470-01765-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 250 Seiten, E-Book

Reihe: Novartis Foundation Symposia

This book features contributions from experts in cell biology,genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shapechange and motility. Several key questions in this field ofresearch are discussed:
* What are the organising principles behind cell shapechange?
* Are there 'master switches' present in every celltype?
* How are extracellular signals interpreted by the cell in orderto activate intracellular mechanisms?
* What is the influence of the extracellular matrix on cellmovement and internal signalling pathways?
* How do pathogens subvert cellular systems in order to stimulateor block their uptake?
The book addresses all of these important questions. Dataare presented on the key proteins that regulate cell shape: the GTPbinding proteins of the Rho family. There are also extensivediscussions of the potential applications of the data to clinicalproblems, particularly that of cell motility in cancer.

Autoren/Hrsg.

Bock, Gregory R.

Goode, Jamie A.

Inhaltsverzeichnis

Novartis Foundation symposium on Signalling networks in cellshape and motility held in collaboration with the Institute of Celland Molecular Biology, Singapore, in Singapore on August 30th-1stSeptember 2004.
Editors:Gregory Bock (Organizer) and Jamie Goode.
This symposium is based on a proposal made by UttamSurana.
Gary Borisy Chair's introduction.
Tadaomi Takenawa - From N-WASP to WAVE: key molecules forregulation of cortical actin organization.
Discussion.
Margaret A. Titus - A conserved role for myosin VII inadhesion.
Discussion.
General discussion I.
David G. Drubin, Marko Kaksonen, Christopher Toret and Yidi Sun- Cytoskeletal networks and pathways involved in endocytosis.
Discussion.
Michele Knaus, Philippe Wiget,Yukiko Shimada and Matthias Peter- Control of cell polarity in response to intra- and extracellularsignals in budding yeast.
Discussion.
Fred Chang, Becket Feierbach and Sophie Martin - Regulation ofactin assembly by microtubules in fission yeast cell polarity.
Discussion.
Atsuo T. Sasaki and Richard A. Firtel - Finding the way:directional sensing and cell polarization through Rassignaling.
Discussion.
Takashi Watanabe, JuNoritake and Kozo Kaibuchi - Roles ofIQGAP1 in cell polarization and migration.
Discussion.
Gregg G. Gundersen,Ying Wen, Christina H. Eng, Jan Schmoranzer,Noemi Cabrera-Poch, EdwardJ. S.Morris,Michael Chen and Edgar R.Gomes - Regulation of microtubules by Rho GTPases in migratingcells.
Discussion.
Eyal D. Schejter - Actin organization in the early Drosophilaembryo.
Discussion.
Yasuyuki Fujita and Vania Braga - Epithelial cell shape and Rhosmall GTPases.
Discussion.
W. James Nelson, Frauke Drees and Soichiro - Yamada Interactionof cadherin with the actin cytoskeleton.
Discussion.
Martin J.Humphries, Zohreh Mostafavi-Pour, Mark R.Morgan,Nicholas O. Deakin, Anthea J. Messent and Mark D. Bass -Integrin-syndecan co-operation governs the assembly of signallingcomplexes during cell spreading.
Discussion.
Keith Mostov, Paul Brakeman, Anirban Datta, Ama Gassama, LeonidKatz, Minji Kim, Pascale Leroy, Max Levin, Kathleen Liu, FernandoMartin, Lucy E. O'Brien, Marcel Verges,Tao Su, Kitty Tang,Naoki Tanimizu,Toshiyuki Yamaji and Wei Yu - Formation ofmulticellular epithelial structures.
Discussion.
Kathryn M. Eisenmann, Jun Peng, Bradley J.Wallar and Arthur S.Alberts - Rho GTPase: formin pairs in cytoskeletal remodeling.
Discussion.
Final discussion.
Index of contributors.
Subject index.

Über Autor(innen)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.