Bolander Molecular Endocrinology

2. Auflage 2013
ISBN: 978-1-4832-8821-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 601 Seiten, Web PDF

Reihe: Human Molecular Genetics

Aimed at graduate level courses, this textbook provides students with a solid background in the basics of molecular endocrinology. Molecular Endocrinology, Second Edition, summarizes the area and provides an in-depth discussion of the molecular aspects of hormone action, including hormone-receptor interactions, second messenger generation, gene induction, and post-transcriptional control. Thoroughly revised and updated, the Second Edition includes new information on growth factors, hematopoietic-immune factors, nonclassical hormones, receptors, transduction, transcriptional regulation, as well as other relevant topics.Incorporating an abundance of new information, this text retains the self-contained, focused, and easily readable style of the First Edition. Professionals in related fields will also find this book to be a helpful summary and general reference source.

Autoren/Hrsg.

Bolander, Franklyn F.

Inhaltsverzeichnis

1;Front Cover;1
2;Molecular Endocrinology;4
3;Copyright Page;5
4;Dedication;6
5;Table of Contents;8
6;Preface to the Second Edition;10
7;Preface to the First Edition;12
8;Part 1: Introduction and General Endocrinology;14
8.1;Chapter 1. Introduction;16
8.1.1;I. Definitions;17
8.1.2;II. Hormone-Target Relationships;18
8.1.3;III. Chemical Nature;20
8.1.4;IV. Biological Activity;22
8.1.5;V. Control;26
8.1.6;VI. Hormonal Control of Calcium Metabolism;28
8.1.7;References;35
8.2;Chapter 2. Classical Endocrinology;37
8.2.1;I. Introduction;38
8.2.2;II. Hypothalamus and Pituitary Gland;38
8.2.3;III. Adrenal Glands;44
8.2.4;IV. The Thyroid Gland;53
8.2.5;V. Reproduction;57
8.2.6;VI. Gastrointestinal Hormones;66
8.2.7;References;73
8.3;Chapter 3. Non-Classical Endocrinology;75
8.3.1;I. Introduction;76
8.3.2;II. Growth Factors;76
8.3.3;III. Invertebrate Hormones;97
8.3.4;IV. Plant Hormones;103
8.3.5;V. Prospective;109
8.3.6;References;109
9;Part 2: Receptors;114
9.1;Chapter 4. Kinetics;116
9.1.1;I. Introduction;117
9.1.2;II. Receptor Assays;118
9.1.3;III. Kinetics;119
9.1.4;IV. lodination;126
9.1.5;V. Receptor Preparations;127
9.1.6;VI. Summary;128
9.1.7;References;129
9.2;Chapter 5. Nuclear Receptors;131
9.2.1;I. Introduction;132
9.2.2;II. Structure;132
9.2.3;III. Families;137
9.2.4;IV. Metabolism;140
9.2.5;V. Nongenomic Actions;147
9.2.6;VI. Summary;149
9.2.7;References;150
9.3;Chapter 6. Membrane Receptors;161
9.3.1;I. Introduction;162
9.3.2;II. Enzyme-Linked Receptors;162
9.3.3;III. Serpentine Receptors;175
9.3.4;IV. Fibronectin-Like Receptors;182
9.3.5;V. Miscellaneous Membrane Receptors;188
9.3.6;VI. Ion Channel Receptors;189
9.3.7;VII. Receptor Metabolism;196
9.3.8;VIII. Miscellaneous Topics;204
9.3.9;IX. Summary;207
9.3.10;References;209
9.4;Chapter 7. Receptor Regulation;235
9.4.1;I. Introduction;236
9.4.2;II. Receptor Number;236
9.4.3;III. Receptor Affinity and Specificity;239
9.4.4;IV. Endogenous Antagonists;241
9.4.5;V. Transduction Uncoupling;242
9.4.6;VI. Developmental Regulation;244
9.4.7;VII. Summary;246
9.4.8;References;247
10;Part 3: Transduction;254
10.1;Chapter 8. G Proteins and Cyclic Nucleotides;256
10.1.1;I. Introduction;257
10.1.2;II. Criteria for Second Messengers;257
10.1.3;III. G Proteins;258
10.1.4;IV. Cyclic AMP Pathway;270
10.1.5;V. Cyclic GMP Pathway;280
10.1.6;VI. Cyclic CMP Pathway;281
10.1.7;VII. Transcellular Signaling;281
10.1.8;VIII. Summary;282
10.1.9;References;282
10.2;Chapter 9. Calcium, Calmodulin, and Phospholipids;295
10.2.1;I. Introduction;296
10.2.2;II. Criteria for Second Messengers;296
10.2.3;III. The Phosphoinositide Effect;300
10.2.4;IV. Other Phospholipids;320
10.2.5;V. Summary;327
10.2.6;References;329
10.3;Chapter 10. Miscellaneous Second Messengers;345
10.3.1;I. Polyamines;346
10.3.2;II. Oligosaccharides;352
10.3.3;III. Cellular pH;354
10.3.4;IV. Cytoskeleton;355
10.3.5;V. Summary;363
10.3.6;References;363
10.4;Chapter 11. Phosphorylation and Other Nontranscriptional Effects of Hormones;371
10.4.1;I. Introduction;372
10.4.2;II. Phosphorylation;372
10.4.3;III. Glucose Transport;388
10.4.4;IV. Summary;391
10.4.5;References;391
11;Part 4: Gene Regulation by Hormones;400
11.1;Chapter. 12 Hormonally Regulated Transcription Factors;402
11.1.1;I. Introduction;403
11.1.2;II. Transcription Factors: General;403
11.1.3;III. Transcription Factors: Specific;412
11.1.4;IV. Specificity Problems;426
11.1.5;V. Mechanisms for Transcription Effects;429
11.1.6;VI. Hormone Response Elements;433
11.1.7;VII. Summary;438
11.1.8;References;438
11.2;Chapter 13. Modifications and Conformations of DNA and Nuclear Proteins;455
11.2.1;I. Introduction;456
11.2.2;II. Chromatin Structure;456
11.2.3;III. Template Activity;471
11.2.4;IV. Summary;476
11.2.5;References;477
11.3;Chapter 14. Post-transcriptional Control;486
11.3.1;I. Introduction;487
11.3.2;II. RNA Processing;487
11.3.3;III. Translation;490
11.3.4;IV. Post-translational Regulation;494
11.3.5;V. Summary;497
11.3.6;References;498
12;Part 5: Special Topics;504
12.1;Chapter 15. Molecular Evolution of the Endocrine System;506
12.1.1;I. Introduction;507
12.1.2;II. Hormones;507
12.1.3;III. Receptors;515
12.1.4;IV. Transducers;521
12.1.5;V. Transcription Factors;527
12.1.6;VI. Evolution of Function;528
12.1.7;VII. Summary;529
12.1.8;References;530
12.2;Chapter 16. Pathogen-Endocrine System Interactions;544
12.2.1;I. Introduction;545
12.2.2;II. Viral and Bacterial Genes;546
12.2.3;III. Anti-oncogenes;552
12.2.4;IV. Summary;555
12.2.5;References;556
12.3;Chapter 17. Molecular Bases of Endocrinopathies;564
12.3.1;I. Introduction;565
12.3.2;II. Hormones;565
12.3.3;III. Receptors;575
12.3.4;IV. Transduction;582
12.3.5;V. Transcription Factors;585
12.3.6;VI. Summary;586
12.3.7;References;586
13;List of Abbreviations;598
14;Index;608