TRP Channels in Drug Discovery

Volume II
Softcover Nachdruck of the original 1. Auflage 2012
ISBN: 978-1-4939-6066-8
Verlag: Humana Press

Buch, Englisch, 489 Seiten, Paperback, Format (B × H): 178 mm x 254 mm, Gewicht: 1286 g

Reihe: Methods in Pharmacology and Toxicology

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.

 
Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Bíró, Tamás

Szallasi, Arpad

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Stoffwechselstörungen
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

TRPs to Cardiovascular Disease.- Anemic Zebrafish Models of Cardiomyopathy.- Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function.- Atherosclerosis Models with Cell-Mediated Calcification.- Models of Hypertension and Blood Pressure Recording.- Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling.- TRP Channels in the Brain.- Investigation of the Possible Role of TRP Channels in Schizophrenia.- Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish.- A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents.- Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory.- Chick Anxiety-Depression Screening Model.- A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat.- Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies.- Methods in Neuronal Growth Cone Biology.- Transient Receptor Potential Channels and Pruritus.- Skin Sensitivity Studies.- Hair Follicle Culture.- Animal Models for Type 1 Diabetes.- Type 2 Diabetes Models.- Using Diet to Induce Metabolic Disease in Rodents.- Rodent Models to Evaluate Anti-Obesity Drugs.- Experimental Colitis Models.- Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis.- Methods to Study Thermonociception in Rodents.- Methods for the Assessment of Heat Perception in Humans.- Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain.- Animal Models of Muscular Dystrophy.