TRP Channels in Drug Discovery

Volume II
2012
ISBN: 978-1-62703-094-6
Verlag: Humana Press

Buch, Englisch, 489 Seiten, HC gerader Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 1135 g

Reihe: Methods in Pharmacology and Toxicology

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.
 
Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Bíró, Tamás

Szallasi, Arpad

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Stoffwechselstörungen

Inhaltsverzeichnis

Part I: TRPs and Cardiovascular Disease 
1. TRPs to Cardiovascular Disease            José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak
 
2. Anemic Zebrafish Models of Cardiomyopathy
            Xiaojing Sun and Xiaolei Xu
 
3. Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function
            Yan Ma, Yung-Wui Tjong, and Xiaoqiang Yao
 
4. Atherosclerosis Models with Cell-Mediated Calcification
            Beili Zhu
 
5. Models of Hypertension and Blood Pressure Recording            Luciana Aparecida Campos and Ovidiu Constantin Baltatu
 
6. Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling
            Wei Zhang and Mohamed Trebak
 
Part II: TRPs and the Brain
 
7. TRP Channels in the Brain
            Antonio Reboreda Prieto
 
8. Investigation of the Possible Role of TRP Channels in Schizophrenia
            Loris A. Chahl
 
9. Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish            Amanda Decker and Robert Cornell
 
10. A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents            Caitlin J. Riebe and Carsten T. Wotjak
 
11. Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory            Jennifer L. McGuire, Jennifer L. Coyner, and Luke R. Johnson
 
12. Chick Anxiety-Depression Screening Model            Stephen W. White and Kenneth J. Sufka
 
13. A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat            Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, and Charles L. Rosen
 
14. Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies            Koji Shibasaki
 
15. Methods in Neuronal Growth Cone Biology            Robert J. Gasperini and Lisa Foa
 
Part III: TRPs and Skin
 
16. Transient Receptor Potential Channels and Pruritus
            Heike Benecke, Janine Wäring, Tobias Lotts, and Sonja Ständer
 
17. Skin Sensitivity Studies            Laurent Misery
 
18. Hair Follicle Culture            Michael P. Philpott
 
Part IV: TRPs and Metabolic Disorders
 
19. Animal Models for Type 1 Diabetes
            Anish Suri and Matteo Levisetti
 
20. Type 2 Diabetes Models
            Dorte X. Gram
 
21. Using Diet to Induce Metabolic Disease in Rodents
            Angela M. Gajda, Michael A. Pellizzon, and Matthew R. Ricci 
22. Rodent Models to Evaluate Anti-Obesity Drugs            Sharon Cheetham and Helen Jackson
 
Part V: TRPs: Colitis, Cancer, Thermosensation, and Musculoskeletal Disorders
 
23. Experimental Colitis Models
            Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, and L. Ashley Blackshaw
 
24. Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis            V’yacheslav Lehen’kyi, Sergii Khalimonchyk, Albin Pourtier, Maylis Raphaël, and Natalia Prevarskaya
 
25. Methods to Study Thermonociception in Rodents
            Kata Bölcskei
 
26. Methods for the Assessment of Heat Perception in Humans
            Michael F. Crutchlow and Joel D. Greenspan
 
27. Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain            Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson
 
28. Animal Models of Muscular Dystrophy
            Yuko Iwata and Shigeo Wakabayashi

            Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson
 
28. Animal Models of Muscular Dystrophy
            Yuko Iwata and Shigeo Wakabayashi

            Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson
 
28. Animal Models of Muscular Dystrophy
            Yuko Iwata and Shigeo Wakabayashi

            Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson