Bronner / Coburn Disorders of Mineral Metabolism

Trace Minerals
1. Auflage 2014
ISBN: 978-1-4832-6587-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 516 Seiten, Web PDF

Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

Autoren/Hrsg.

Bronner, Felix

Coburn, Jack W.

Inhaltsverzeichnis

1;Front Cover;1
2;Trace Minerals;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;12
6;Preface;14
7;Contents of Other Volumes;16
8;Chapter 1. Iron;18
8.1;I. INORGANIC BIOCHEMISTRY;19
8.2;II. IRON-CONTAINING PROTEINS;19
8.3;III. IRON ABSORPTION;26
8.4;IV. INTERNAL METABOLISM;28
8.5;V. METHODS USED FOR CLINICAL INVESTIGATION;35
8.6;VI. IRON DEFICIENCY;40
8.7;VII. IRON OVERLOAD;49
8.8;VIII. METABOLIC ABERRATIONS;54
8.9;REFERENCES;59
9;Chapter 2. Copper;76
9.1;I. NORMAL COPPER METABOLISM;77
9.2;II. ABNORMAL COPPER METABOLISM;89
9.3;REFERENCES;103
10;Chapter 3. Zinc in Human Nutrition;110
10.1;I. INTRODUCTION;111
10.2;II. BIOCHEMICAL FUNCTIONS;113
10.3;III. EXPERIMENTAL DEFICIENCY IN LABORATORY ANIMALS;116
10.4;IV. ZINC METABOLISM;120
10.5;VI. ASSESSMENT OF ZINC NUTRITURE;129
10.6;VI. ZINC IN FOODS;131
10.7;VII. ZINC REQUIREMENTS;132
10.8;VIII. HUMAN ZINC DEFICIENCY;137
10.9;IX. EXPERIMENTAL ZINC DEFICIENCY IN MAN;153
10.10;X. NUTRITIONAL INTERACTIONS AND TOXICITY;155
10.11;REFERENCES;157
11;Chapter 4. Lead;176
11.1;I. INTRODUCTION;177
11.2;II. ENVIRONMENTAL SOURCES AND TRANSPORT OF LEAD;177
11.3;III. HUMAN EXPOSURE AND METABOLISM;179
11.4;IV. CELLULAR REACTIONS TO LEAD;183
11.5;V. NEUROLOGICAL EFFECTS;188
11.6;VI. HEMATOLOGICAL EFFECTS;194
11.7;VII. RENAL EFFECTS;197
11.8;VIII. EFFECTS OF LEAD ON REPRODUCTION AND DEVELOPMENT;200
11.9;IX. EFFECTS ON THE IMMUNE SYSTEM;201
11.10;X. INTERACTIONS WITH OTHER MINERALS;202
11.11;XI. LEAD IN BONE AND TEETH;204
11.12;XII. CLINICAL RECOGNITION OF LEAD TOXICITY;204
11.13;XIII. ESSENTIALITY OF LEAD;206
11.14;XIV. TREATMENT OF LEAD TOXICITY;207
11.15;REFERENCES;207
12;Chapter 5. Nickel;218
12.1;I. INTRODUCTION;219
12.2;II. NICKEL METABOLISM;219
12.3;III. NICKEL CARBONYL POISONING;225
12.4;IV. NICKEL CARCINOGENESIS;228
12.5;V. OTHER ASPECTS OF NICKEL TOXICOLOGY;231
12.6;VI. SUMMARY;239
12.7;REFERENCES;239
13;Chapter 6. Manganese;250
13.1;I. INTRODUCTION;251
13.2;II. ANALYSES OF MN IN BIOLOGICAL MATERIALS;252
13.3;III. METABOLISM OF MN IN VITRO;254
13.4;IV. MN REQUIREMENTS IN NORMAL NUTRITION;255
13.5;V. ABSORPTION AND EXCRETION OF MN;263
13.6;VI. MN TURNOVER—SPECIFICITY;265
13.7;VII. MN DEFICIENCY;268
13.8;VIII. MN EXCESS;270
13.9;IX. SUSCEPTIBILITY TO MN POISONING;279
13.10;X. CONCLUSIONS AND SUMMARY;281
13.11;REFERENCES;281
14;Chapter 7. Chromium;288
14.1;I. BIOLOGICAL ROLE OF CHROMIUM IN MAMMALS;289
14.2;II. CHROMIUM METABOLISM;294
14.3;III. HUMAN CHROMIUM NUTRITION AND DEFICIENCY;297
14.4;IV. CONCLUDING REMARKS;305
14.5;ACKNOWLEDGMENTS;306
14.6;REFERENCES;306
15;Chapter 8. Molybdenum;312
15.1;I. INTRODUCTION;312
15.2;II. DIETARY INTAKE AND BODY BURDEN;313
15.3;III. Essentiality;315
15.4;IV. BIOCHEMISTRY;317
15.5;V. PHARMACOLOGY;320
15.6;VI. TOXICITY;325
15.7;REFERENCES;328
16;Chapter 9. Cadmium;334
16.1;I. OCCURRENCE AND EXPOSURE;335
16.2;II. REVIEW OF EFFECTS;340
16.3;III. METABOLISM;344
16.4;IV. CADMIUM-INDUCED RENAL DAMAGE;352
16.5;V. EFFECTS ON VITAMIN D METABOLISM;356
16.6;VI. EFFECTS ON BONES;357
16.7;REFERENCES;363
17;Chapter 10. Aluminum and Tin;370
17.1;I. ALUMINUM;370
17.2;II. TIN;377
17.3;REFERENCES;380
18;Chapter 11. Lithium;386
18.1;I. CHEMISTRY;387
18.2;II. BIOLOGY;388
18.3;III. PHARMACOKINETICS;394
18.4;IV. INTERACTIONS OF LITHIUM WITH SPECIFIC HOMEOSTATIC SYSTEMS;400
18.5;REFERENCES;436
19;Chapter 12. Fluoride;456
19.1;I. INTRODUCTION;457
19.2;II. FLUORIDE INTAKE;457
19.3;III. ABSORPTION OF FLUORIDE;460
19.4;IV. DISTRIBUTION;464
19.5;V. SKELETAL DEPOSITION: FLUORIDE, A BONE SEEKER;472
19.6;VI. MOBILIZATION;476
19.7;VII. EXCRETION;478
19.8;VIII. PREGNANCY AND THE FETUS;483
19.9;IX. ESSENTIALITY;484
19.10;X. CYCLIC ADENOSINE MONOPHOSPHATE (cAMP);485
19.11;XI. OSTEOPOROSIS;485
19.12;XII. OTOSCLEROSIS;486
19.13;XIII. SOME TOXIC FLUORIDE EFFECTS IN MAN;486
19.14;XIV. ORGANIC FLUORIDE;489
19.15;ACKNOWLEDGMENT;489
19.16;REFERENCES;489
20;Index;502