Iron Acquisition by the Genus Mycobacterium

History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
2013
ISBN: 978-3-319-00302-3
Verlag: Springer International Publishing

Buch, Englisch, 92 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 166 g

Reihe: SpringerBriefs in Biometals

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Zielgruppe

Research

Autoren/Hrsg.

Byers, B. Rowe

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Bakteriologie

Inhaltsverzeichnis

A History of Iron Metabolism in the Mycobacteria.- Mycobacterial Iron Uptake Mechanisms.- Siderocalin Combats Mycobacterial Infections.- Design of Anti-TB Drugs Using the Iron Uptake Platform.