History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
E-Book, Englisch, 92 Seiten, eBook
Reihe: SpringerBriefs in Molecular Science
ISBN: 978-3-319-00303-0
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)
Iron Acquisition by the Genus
Mycobacterium
summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by
M. tuberculosis
is featured. Because new drugs for
M. tuberculosis
are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Byers
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Mycobacterium
summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by
M. tuberculosis
is featured. Because new drugs for
M. tuberculosis
are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
A History of Iron Metabolism in the Mycobacteria.- Mycobacterial Iron Uptake Mechanisms.- Siderocalin Combats Mycobacterial Infections.- Design of Anti-TB Drugs Using the Iron Uptake Platform.
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