Byrne / Heidelberger / Waxham From Molecules to Networks

An Introduction to Cellular and Molecular Neuroscience
1. Auflage 2003
ISBN: 978-0-08-049135-6
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 583 Seiten

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.* Highly referenced for readers to pursue topics of interest in greater detail* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks* Richly illustrated, four color presentation throughout* Includes CD-ROM of all of the illustrations

Autoren/Hrsg.

Byrne, John H.

Heidelberger, Ruth

Waxham, M. Neal

Roberts, James L.

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;5
3;Full Contents;8
4;Contributors;12
5;Preface;14
6;Chapter 1. Cellular Components of Nervous Tissue;16
6.1;The Neuron;16
6.2;The Neuroglia;28
6.3;The Cerebral Vasculature;37
7;Chapter 2. Subcellular Organization of the Nervous System: Organelles and Their Functions;46
7.1;Axons and Dendrites: Unique Structural Components of Neurons;46
7.2;Protein Synthesis in Nervous Tissue;51
7.3;The Cytoskeletons of Neurons and Glial Cells;62
7.4;Molecular Motors in the Nervous System;70
7.5;Building and Maintaining Nervous System Cells;73
8;Chapter 3. Brain Energy Metabolism;82
8.1;Energy Metabolism of the Brain as a Whole Organ;82
8.2;Tight Coupling of Neuronal Activity, Blood Flow, and Energy Metabolism;85
8.3;Energy-Producing and Energy-Consuming Processes in the Brain;88
8.4;Brain Energy Metabolism at the Cellular Level;92
8.5;Glutamate and Nitrogen Metabolism: A Coordinated Shuttle Between Astrocytes and Neurons;99
8.6;The Astrocyte–Neuron Metabolic Unit;102
9;Chapter 4. Electrotonic Properties of Axons and Dendrites;106
9.1;Spread of Steady-State Signals;108
9.2;Spread of Transient Signals;113
9.3;Electrotonic Properties Underlying Propagation in Axons;115
9.4;Electrotonic Spread in Dendrites;117
9.5;Dynamic Properties of Passive Electrotonic Structure;121
9.6;Relating Passive to Active Potentials;126
10;Chapter 5. Membrane Potential and Action Potential;130
10.1;The Membrane Potential;131
10.2;The Action Potential;136
11;Chapter 6. Molecular Properties of Ion Channels;156
11.1;Families of Ion Channels;156
11.2;Channel Gating;159
11.3;Ion Permeation;164
11.4;Ion Channel Distribution;169
11.5;Summary;172
12;Chapter 7. Dynamical Properties of Excitable Membranes;176
12.1;The Hodgkin–Huxley Model;176
12.2;A Geometric Analysis of Excitability;194
13;Chapter 8. Release of Neurotransmitters;212
13.1;Organization of the Chemical Synapse;212
13.2;Excitation–Secretion Coupling;217
13.3;The Molecular Mechanisms of the Nerve Terminal;223
13.4;Quantal Analysis;236
13.5;Short-Term Synaptic Plasticity;250
14;Chapter 9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters;260
14.1;Diverse Modes of Neuronal Communication;260
14.2;Chemical Transmission;261
14.3;Classic Neurotransmitters;265
14.4;Summary;291
15;Chapter 10. Nonclassic Signaling in the Brain;294
15.1;Peptide Neurotransmitters;294
15.2;Neurotensin as an Example of Peptide Neurotransmitters;300
15.3;Unconventional Transmitters;302
15.4;Synaptic Transmitters in Perspective;310
16;Chapter 11. Neurotransmitter Receptors;314
16.1;Ionotropic Receptors;314
16.2;G Protein-Coupled Receptors;334
17;Chapter 12. Intracellular Signaling;350
17.1;Signaling Through G-Protein-Linked Receptors;350
17.2;Modulation of Neuronal Function by Protein Kinases and Phosphatases;368
18;Chapter 13. Regulation of Neuronal Gene Expression and Protein Synthesis;386
18.1;Intracellular Signaling Affects Nuclear Gene Expression;386
18.2;Role of cAMP and Ca2+ in the Activation Pathways of Transcription;395
18.3;Summary;403
19;Chapter 14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways;406
19.1;Methods for Modelling Intracellular Signaling Pathways;408
19.2;General Issues in the Modeling of Biochemical Systems;423
19.3;Specific Modeling Methods;426
19.4;Summary;441
20;Chapter 15. Cell–Cell Communication: An Overview Emphasizing Gap Junctions;446
20.1;Chemical and Electrical Synapses Differ in Functional Characteristics;450
20.2;Biophysical and Pharmacological Properties of Gap Junctions in the Nervous System;454
20.3;Role of Gap Junctions in Functions of Nervous Tissue;457
20.4;Gap Junction-Related Neuropathologies;463
21;Chapter 16. Postsynaptic Potentials and Synaptic Integration;474
21.1;Ionotropic Receptors: Mediators of Fast Excitatory and Inhibitory Synaptic Potentials;474
21.2;Metabotropic Receptors: Mediators of Slow Synaptic Potentials;487
21.3;Integration of Synaptic Potentials;490
22;Chapter 17. Information Processing in Complex Dendrites;494
22.1;Strategies for Studying Complex Dendrites;495
22.2;Summary: The Dendritic Tree as a Complex Information Processing System;510
23;Chapter 18. Learning and Memory: Basic Mechanisms;514
23.1;Long-Term Synaptic Potentiation and Depression;514
23.2;Paradigms Have Been Developed To Study Associative and Nonassociative Learning;544
23.3;Invertebrate Studies: Key Insights From Aplysia Into Basic Mechanisms of Learning;546
23.4;Classical Conditioning in Vertebrates: Discrete Responses and Fear as Models of Associative Learning;558
23.5;How Does a Change in Synaptic Strength Store Complex Memory?;575
23.6;Summary;577
24;Index;590