Chadwick / Goode Inflammatory Bowel Disease

Crossroads of Microbes, Epithelium and Immune Systems
1. Auflage 2005
ISBN: 978-0-470-09047-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 238 Seiten, E-Book

Reihe: Novartis Foundation Symposia

Inflammatory bowel disease (IBD) comprises a group of idiopathicdiseases of the intestine characterized by chronic inflammation ofthe bowel with periods of exacerbation and remission. Although theexact cause of IBD remains undetermined, the condition appears tobe related to a combination of genetic and environmental factorsresulting in an aberrant activation of the mucosal immune system.This book contains a series of interdisciplinary discussionsbetween clinical and basic scientists focusing on key issues suchas:
* Epithelial cell and molecular biology, including apoptosis,necrosis and cell survival
* The role of bacterial milieu and mucosal bacteria in the IBDand of prebiotic and probiotic therapy
* The progress towards the identification of susceptibility genesand phenotype-determining genes
* The pharmacogenetics of IBD
* Mucosal immunology and therapeutic strategies stemmingtherefrom

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (Jewell).
Progress toward identifying inflammatory bowel diseasesusceptibility genes (Rioux).
Phenotype-determining genes in inflammatory bowel disease(Ahmad).
Pharmacogenetics of inflammatory bowel disease (Kelleher etal).
Bacterial milieu and mucosal bacteria in ulcerative colitis(Macfarlane et al).
Defensins and mucosal protection (Mahid and Cunliffe).
Intestinal mycoplasma in Crohn's Disease (Roediger).
Kong Probiotics, prebiotics and antibiotics in inflammatorybowel disease (Cummings and Choon).
The eipthelium in inflammatory bowel disease: potential role ofendocytosis of junctional proteins in barrier disruption (Ivanov etal).
Apoptosis or necrosis - colonic epithelial cell survival(Gibson).
Genetic aspects of intestinal permeability in inflammatory boweldisease (Takeuchi et al).
Animal models of intestinal inflammation: clues to thepathogenesis of inflammatory bowel disease (Powrie and Uhlig).
Homing of intestinal immune cells (Uhlig et al).
Anti-TNF therapy in Crohn's Disease (Ghosh).
Index of contributors.
Subject index.