Chaughule Dental Applications of Nanotechnology

1. Auflage 2018
ISBN: 978-3-319-97634-1
Verlag: Springer Nature Switzerland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 284 Seiten

Reihe: Chemistry and Materials Science

This book discusses current trends and potential areas of nanotechnology applications in dental materials. Dentistry is undergoing yet another change to benefit mankind via the discipline of nanodentistry.  A variety of nanostructures such as nanorobots, nanospheres, nanofibers, nanorods, etc., have been studied for various applications in dentistry and medicine. Preventive dentistry has also utilized nanodentistry to develop the nanomaterials for inclusion in a variety of oral health-care products. Methods to prevent and combat dental problems have been devised, discussed, and implemented since ancient times; however, there is a constant need for improved tools and techniques. This book is relevant academically for undergraduate and   post-graduate dental students, dental practitioners, researchers, and faculties of dental universities, as this book explores the application of various nanobiomaterials in  dentistry, discusses current research in dental nanomaterials and potential future areas of interest, and examines the use of nanotechnology in various  fields of dentistry.


Dr. Ramesh S. Chaughule, Ex Scientist from Tata Institute of Fundamental Research, Mumbai, India, is an Adjunct Professor at Ramnarain Ruia College, Mumbai India,  Research Advisor at Gogate Jogalekar College, Maharashtra, and a Fellow of Maharashtra Academy of Sciences. He is also the recipient of Indo-UK, Indo-USA, and Indo-Japan fellowships, and has more than 80 publications as papers and books in his field of research. He has also served on IAEA programs in Indonesia.

Autoren/Hrsg.

Chaughule, Ramesh S.

Inhaltsverzeichnis

1;Foreword I;6
2;Foreword II;8
3;Preface;10
4;Contents;14
5;1 Nano-materials in Regenerative Pulp Treatment;16
5.1;1.1 The Construction of Tooth’s Tissues;16
5.2;1.2 Caries;17
5.3;1.3 Fluoride and Remineralization Process;19
5.4;1.4 Minimally Invasive Dentistry;19
5.5;1.5 Characteristics of Dental Biomaterials;22
5.6;1.6 Nano-materials;24
5.6.1;1.6.1 Nano-hydroxyapatite (Nano-HPA);24
5.6.2;1.6.2 Nano-bioactive glass (Nano-BAG);25
5.7;1.7 Summary;33
5.8;References;33
6;2 Nanobiomaterials and Their Role in Periodontal Rehabilitation;38
6.1;2.1 Introduction;38
6.1.1;2.1.1 Brief Introduction of Nanotechnology in Periodontics;38
6.2;2.2 Nanocrystalline Bone Grafts in Bone Regeneration;39
6.3;2.3 Preparation Methods of HA Nanoparticles;40
6.4;2.4 Nanotechnology and Dental Implants;46
6.5;2.5 Nanotechnology in the Management of Peri-implantitis;47
6.6;2.6 Nanomaterials for Periodontal Tissue Engineering;48
6.7;2.7 Conclusion;49
6.8;References;49
7;3 Advanced Nanomaterials and Their Functionalization in Clinical Endodontics;51
7.1;3.1 Introduction;51
7.1.1;3.1.1 Types of Nanotechnologies;51
7.1.2;3.1.2 Types of Nanoparticles (NPs);52
7.1.3;3.1.3 Properties of Nanoparticles;52
7.2;3.2 Nanotechnology in Medicine;52
7.3;3.3 Nanotechnology and Nanobiomaterials in Dentistry;53
7.4;3.4 Nanotechnology in Endodontics;53
7.4.1;3.4.1 Radiography;55
7.4.2;3.4.2 Local Anesthesia;55
7.4.3;3.4.3 Dentin Hypersensitivity;55
7.4.4;3.4.4 Cleaning of Endodontic Instruments;55
7.4.5;3.4.5 Root Canal Disinfection: Nanoparticle-Based Disinfection;56
7.4.6;3.4.6 Endodontic Filling Materials;56
7.4.7;3.4.7 Root Canal Disinfection;59
7.4.8;3.4.8 Functionalization/Conjugation;60
7.4.9;3.4.9 Dentin Stabilization;60
7.4.10;3.4.10 Endodontic Filling Materials;61
7.4.11;3.4.11 Temporization;64
7.5;3.5 Nanobiomaterials in Endodontics;64
7.5.1;3.5.1 Vital Pulp Therapy;64
7.5.2;3.5.2 Regenerative Endodontics;65
7.5.3;3.5.3 Endodontic Surgery;65
7.6;3.6 Conclusion;66
7.7;References;66
8;4 Nanocomposites and Their Use in Dentistry;72
8.1;4.1 Introduction;72
8.2;4.2 History of Composite Materials;73
8.3;4.3 Dental Composite Materials;73
8.3.1;4.3.1 Dental Resin Matrix;74
8.3.2;4.3.2 Fillers;77
8.3.3;4.3.3 Coupling Agents;82
8.3.4;4.3.4 Photo-Initiating Agents;85
8.4;4.4 Nanotechnology in Dentistry;85
8.4.1;4.4.1 Need of Nanotechnology;85
8.4.2;4.4.2 Nano in Composite Resins;86
8.4.3;4.4.3 Current Progress;88
8.5;4.5 Challenges and Future Outlook;89
8.6;References;90
9;5 Applications of Nanoparticles in Orthodontics;93
9.1;5.1 Background;93
9.1.1;5.1.1 Introduction;93
9.1.2;5.1.2 Definitions;94
9.1.3;5.1.3 Historical Background;94
9.2;5.2 Shapes and Types of Nanoparticles;95
9.2.1;5.2.1 Carbon-Based Materials;95
9.2.2;5.2.2 Metal-Based Materials;98
9.2.3;5.2.3 Dendrimers;98
9.2.4;5.2.4 Nanocomposites;98
9.3;5.3 Properties of Nanoparticles;99
9.4;5.4 Synthesis of Nanoparticles;100
9.5;5.5 Applications of Nanoparticles in Dentistry;101
9.6;5.6 Applications of Nanoparticles in Orthodontics;102
9.6.1;5.6.1 Application as Antimicrobial Agent;103
9.6.2;5.6.2 Application as Lubricating Agent to Reduce Friction;104
9.6.3;5.6.3 Fabrication of Hollow Wires;106
9.6.4;5.6.4 Fabrication of Orthodontic Brackets;107
9.6.5;5.6.5 Use of Nanoparticles in Evolving the Cell-Matrix Interface;107
9.6.6;5.6.6 Nanomaterials as Nanofillers in Orthodontics;109
9.6.7;5.6.7 Nanoparticles as Enamel Remineralizing Agents;109
9.6.8;5.6.8 Self-healing Materials;109
9.6.9;5.6.9 Nanoparticles in Bioimaging;110
9.7;5.7 Mechanism of Action of Various Nanoparticles;110
9.8;5.8 Toxicity;110
9.9;5.9 Conclusion;112
9.10;References;113
10;6 Nanomaterials: A Boon to Prosthodontics;118
10.1;6.1 Introduction;118
10.2;6.2 Nanoparticles in Denture Base Resins (Polymethyl Methacrylate)—PMMA;120
10.2.1;6.2.1 Denture Stomatitis or Candidiasis;120
10.3;6.3 Silver Nanoparticles in Tissue Conditioners;122
10.4;6.4 Nanoparticles in Impression Materials;123
10.5;6.5 Nanoceramics;124
10.6;6.6 Luting Cements and Nanoparticles;125
10.7;6.7 Dental Adhesives;125
10.8;6.8 Silver Nanoparticles in Maxillofacial Prosthesis;126
10.9;6.9 Silver Nanoparticles in Dental Implants;126
10.10;6.10 Conclusion;127
10.11;References;127
11;7 Nanomaterials: The Changing Phase of Prosthodontics;131
11.1;7.1 Introduction;131
11.1.1;7.1.1 Approaches in Nanotechnology;132
11.1.2;7.1.2 Synthesis of Nanomaterials in Prosthodontics;132
11.2;7.2 Application of Nanodentistry in Prosthodontics;133
11.2.1;7.2.1 Nanoparticles in Resin Polymethyl Methacrylate;134
11.2.2;7.2.2 Nanoceramic Materials;135
11.2.3;7.2.3 Nanoparticles in Impression Material;137
11.2.4;7.2.4 Nanoparticles in Maxillofacial Materials;137
11.2.5;7.2.5 Nanoparticles in Hybrid Resin Luting Cement;138
11.2.6;7.2.6 Nanometal Material and Dental Implants;138
11.2.7;7.2.7 Nanoparticles in Tissue Conditioner;140
11.3;7.3 Summary;140
11.4;References;140
12;8 Nanostructures in Dentistry: In Diagnosis, Drug Delivery and Oral Cancer Therapy, and their Biocompatibility;143
12.1;8.1 Introduction;143
12.1.1;8.1.1 Nanotechnology;143
12.1.2;8.1.2 Principle of Nanotechnology;144
12.1.3;8.1.3 Advantages of Using Nanotechnology in Dentistry;144
12.1.4;8.1.4 Applications of Nanotechnology in Dentistry;145
12.2;8.2 Nanomedicine;145
12.2.1;8.2.1 Types of Nanotechnologies in Nanomedicine;146
12.2.2;8.2.2 Nanosensors;146
12.2.3;8.2.3 Nanophase Materials;146
12.2.4;8.2.4 Nanorobots;146
12.3;8.3 Nanotechnology in Dentistry: Approaches to Nanotechnology;148
12.3.1;8.3.1 Bottom-up Approach (Self-assembly);148
12.3.2;8.3.2 Top-Down Approach;148
12.3.3;8.3.3 The Functional Approach;149
12.3.4;8.3.4 The Biomimetic Approaches;149
12.3.5;8.3.5 Speculative;149
12.4;8.4 Therapeutic Nanostructures in Dentistry;149
12.4.1;8.4.1 Nanomaterials;151
12.4.2;8.4.2 Classification of Nanomaterials;151
12.4.3;8.4.3 Nanostructures Used in Dentistry;152
12.5;8.5 Nanodiagnostics: Diagnosis of Oral Cancer and Other Diseases;155
12.5.1;8.5.1 Advantages of Using Nanodiagnostics;155
12.5.2;8.5.2 Various Techniques Used in Nanodiagnosis;155
12.6;8.6 Nanoencapsulation and Nanotherapeutics— Nanoparticles as Dental Drug Delivery Systems;157
12.6.1;8.6.1 Advantages of Nanoparticles as Dental Drug Delivery Systems;158
12.6.2;8.6.2 Drug Delivery by Liposomes;158
12.6.3;8.6.3 Nanoencapsulation;159
12.7;8.7 Nanobiomaterials in Oral Cancer Therapy;159
12.7.1;8.7.1 Nanoshells;159
12.7.2;8.7.2 Dendrimers;159
12.7.3;8.7.3 Nanomaterials for Brachytherapy;160
12.7.4;8.7.4 Gene Therapy;160
12.8;8.8 Challenges Faced by Nanotechnology;160
12.9;8.9 Biocompatibility of Nanaomaterials;160
12.9.1;8.9.1 Biological Consequences of Nanomaterials;161
12.9.2;8.9.2 Regulations for Control;161
12.10;8.10 Future Perspective of Nanotechnology in Dentistry;162
12.11;8.11 Conclusion;162
12.12;References;163
13;9 Nanotechnology in Orthodontics—Futuristic Approach;165
13.1;9.1 Introduction;165
13.1.1;9.1.1 Definition;165
13.1.2;9.1.2 Classification of Nanomaterials;166
13.1.3;9.1.3 Approaches Followed in Production of Nanoparticles;166
13.2;9.2 Nanotechnology and Orthodontic Archwires;166
13.2.1;9.2.1 Nanocoatings in Archwires;167
13.2.2;9.2.2 Shape-Memory esthetic Polymer Wires;167
13.2.3;9.2.3 Hollow NiTi Wires;168
13.3;9.3 Nanotechnology and Orthodontic Adhesives;169
13.3.1;9.3.1 Reduced Polymerization Shrinkage and Increased Mechanical Properties;169
13.3.2;9.3.2 Literature Review of Nanocomposites;169
13.3.3;9.3.3 What Are Nanocomposites?;170
13.3.4;9.3.4 Advantages of Nanocomposites;170
13.4;9.4 Nanotechnology and Elastomeric Ligatures;170
13.5;9.5 Nanoenamel Remineralization Agents in Orthodontics;171
13.5.1;9.5.1 Antibacterial Nanoparticles;171
13.5.2;9.5.2 Review of Nanoenamel Remineralization Agents and Antibacterial Properties;172
13.6;9.6 Nanotechnology and Orthodontic Miniscrews;174
13.6.1;9.6.1 Nanoparticles in Miniscrews to Prevent Infection of Implants;174
13.6.2;9.6.2 Ideal Mini-Implant Surface Using Nanoparticles;175
13.7;9.7 Nanotechnology for Rapid Tooth Movement in Orthodontics;176
13.7.1;9.7.1 Terminologies;176
13.7.2;9.7.2 Application of Bio-MEMS and NEMS;176
13.8;9.8 Nanotechnology for Bone Growth and Prevention of Root Resorption in Orthodontics;177
13.8.1;9.8.1 NanoLIPUS Devices for Bone Growth;177
13.8.2;9.8.2 NanoLIPUS Devices to Prevent Root Resorption in Orthodontics;177
13.9;9.9 Nanotechnology and Orthodontic Brackets;178
13.9.1;9.9.1 Smart Brackets with Nanomechanical Sensors;178
13.9.2;9.9.2 Nanorobotics Coupled with Smart Brackets—Futuristic Approach;178
13.10;9.10 Probable Risks of Nanotechnology;179
13.11;9.11 Conclusion;179
13.12;References;180
14;10 Nanobiomaterials and Their Application in Prosthodontics;186
14.1;10.1 Introduction;186
14.1.1;10.1.1 Nanotechnology Definition;187
14.1.2;10.1.2 Historical Review;187
14.1.3;10.1.3 Classification of Nanomaterials;188
14.1.4;10.1.4 Approaches in Nanotechnology;188
14.2;10.2 Need for Nanotechnology in Dentistry;189
14.3;10.3 Applications of Nanotechnology;191
14.4;10.4 Nanobiomaterials in Prosthodontics;191
14.4.1;10.4.1 Removable Prosthodontics;192
14.4.2;10.4.2 Tooth-Supported Fixed Prosthodontics;195
14.4.3;10.4.3 Implant-Supported Fixed Prosthodontics;205
14.5;10.5 Social Implications;208
14.6;10.6 Conclusion;208
14.7;References;209
15;11 Nanomaterials for the Management of Periodontal Diseases;211
15.1;11.1 Introduction;211
15.2;11.2 Nanorobotic Dentifrices;211
15.3;11.3 Hypersensitivity Management;212
15.4;11.4 Drug Delivery;213
15.4.1;11.4.1 Nanoparticles;214
15.5;11.5 Anti-biofilm Approaches;215
15.5.1;11.5.1 Zinc Oxide (ZnO) Nanoparticles;217
15.5.2;11.5.2 Silver Nanoparticles (AgNPs);217
15.5.3;11.5.3 Nano-hydroxyapatite-Modified Surfaces;219
15.5.4;11.5.4 Other Coatings with Anti-adhesion and Antibacterial Properties;219
15.6;11.6 Role of Nano-proresolving Medicines in Management of Periodontal Diseases;220
15.7;11.7 Conclusion;220
15.8;References;220
16;12 Oral Biofilms: From Development to Assessment and Treatment;224
16.1;12.1 Introduction;224
16.1.1;12.1.1 Variables Related to Cell Adhesion and Biofilm Formation;225
16.1.2;12.1.2 Biofilm Architecture;227
16.2;12.2 Biofilms in the Oral Cavity;227
16.3;12.3 Controlling Biofilms;230
16.4;12.4 In Vitro Biofilm Quantification;231
16.5;12.5 Nanoparticulate Metals as Antimicrobial Agents;231
16.5.1;12.5.1 Silver;232
16.5.2;12.5.2 Copper (Cu);235
16.5.3;12.5.3 Gold;235
16.6;12.6 Nanoparticulate Metal Oxide;236
16.6.1;12.6.1 Copper Oxide;236
16.6.2;12.6.2 Zinc Oxide;236
16.6.3;12.6.3 Titanium Dioxide (TiO2);237
16.7;12.7 Anti-adhesive Nanoparticles;237
16.7.1;12.7.1 Chitosan;237
16.7.2;12.7.2 Silica Nanoparticles;238
16.8;12.8 Surface-Modified Silica Nanoparticles;239
16.9;12.9 Bioglasses and Bioceramics;239
16.10;12.10 Photodynamic Therapy and the Use of Nanoparticles to Control Oral Biofilms;240
16.11;12.11 Biofilm Removal in Dental Unit Water Lines;242
16.11.1;12.11.1 Nanotechnology for Water Decontamination;242
16.11.2;12.11.2 Other Techniques;244
16.11.3;12.11.3 Disadvantages of Using Nanotechnology for Water Treatment;246
16.12;12.12 Conclusion;246
16.13;References;246
17;13 Physical Properties and Biocompatibility of Nanostructural Biomaterials Based on Active Calcium Silicate Systems and Hydroxyapatite;254
17.1;13.1 Introduction;254
17.2;13.2 New Nanostructured Biomaterials;255
17.3;13.3 Physical Properties;256
17.3.1;13.3.1 Solubility;256
17.3.2;13.3.2 Marginal Microleakage;258
17.3.3;13.3.3 The Bond Strength to Dentin;259
17.4;13.4 Biocompatibility;261
17.4.1;13.4.1 Genotoxicity;262
17.4.2;13.4.2 Cytotoxicity;263
17.5;13.5 Bioinductivity;266
17.5.1;13.5.1 Direct Pulp Capping in Rabbits;267
17.5.2;13.5.2 Direct Pulp Capping in Vietnamese Pigs;270
17.6;13.6 Conclusion;275
17.7;References;275
18;14 Correction to: Advanced Nanomaterials and Their Functionalization in Clinical Endodontics;279
18.1;Correction to: Chapter 3 in: R. S. Chaughule (ed.), Dental Applications of Nanotechnology, https://doi.org/10.1007/978-3-319-97634-1_3;279
19;Index;280