Clow / Hucklebridge Neurobiology of the Immune System

1. Auflage 2003
ISBN: 978-0-08-049160-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 52, 442 Seiten, Web PDF

Reihe: International Review of Neurobiology

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. - Provides solid scientific basis to our understanding of the associations between the brain and the immune system the importance of these connections - Presents coherent development from cellular and molecular neuroimmune communication to social and health considerations, including psychological intervention - Addresses the theory that there is a neurobiology of the immune system

Autoren/Hrsg.

Clow, Angela

Hucklebridge, Frank

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;5
3;Contents;6
4;Contributors;12
5;Preface;14
6;Chapter 1. Neuroimmune Relationships in Perspective;16
6.1;I. Introduction;16
6.2;II. Innate and Acquired Immunity;17
6.3;III. The Neuroendocrine System and the Balance of the Immune System;24
6.4;IV. Conclusions;29
7;Chapter 2. Sympathetic Nervous System Interaction with the Immune System;32
7.1;I. Introduction;32
7.2;II. Anatomy and Physiology;33
7.3;III. Adrenergic Receptor Expression on Immune Cells;36
7.4;IV. Effect of ß2AR Stimulation on CD4+ T Lymphocytes;40
7.5;V. Effect of ß2AR Stimulation on B Lymphocytes;43
7.6;VI. Conclusion;46
7.7;References;47
8;Chapter 3. Mechanisms by Which Cytokines Signal the Brain;58
8.1;I. Introduction;58
8.2;II. Interleukin-1 (IL-1);64
8.3;III. Conclusions;73
8.4;References;74
9;Chapter 4. Neuropeptides: Modulators of Immune Responses in Health and Disease;82
9.1;I. Introduction;82
9.2;II. CRH and Related Peptides;83
9.3;III. Pro-opiomelanocortin (POMC) Peptides;85
9.4;IV. Opioid Peptides Other Than ß-Endorphin;90
9.5;V. Trophic Peptides;94
9.6;VI. Other Immunoneuropeptides;95
9.7;VII. Quantitative Analysis of Immunoneuropeptides by MACS;96
9.8;VIII. Conclusions;97
9.9;References;99
10;Chapter 5. Brain–immune Interactions in Sleep;108
10.1;I. Sleep;108
10.2;II. Microbial Products and Cytokines: A Brief Overview;113
10.3;III. Effects of Microbial Products and Cytokines on Sleep;117
10.4;IV. Effect of Sleep–Wake Activity on Cytokines and the Immune System;126
10.5;V. Summary;136
10.6;References;138
11;Chapter 6. Neuroendocrinology of Autoimmunity;148
11.1;I. Introduction;148
11.2;II. The Hypothalamic-Pituitary-Adrenal (HPA) Axis;149
11.3;III. The HPA Axis in Autoimmune Disease;153
11.4;IV. Neurotransmitters in Disease;166
11.5;V. Summary;169
11.6;References;170
12;Chapter 7. Systemic Stress-Induced Th2 Shift and Its Clinical Implications;178
12.1;I. Introduction;178
12.2;II. Th1/Th2 Paradigm: Role of Type 1 and Type 2 Cytokines;179
12.3;III. Stress Hormones and Th1/Th2 Balance ;181
12.4;IV. Clinical Implications;186
12.5;V. Conclusions;194
12.6;References;195
13;Chapter 8. Neural Control of Salivary S-IgA Secretion;202
13.1;I. Introduction;202
13.2;II. Nerve-Mediated Increases in Salivary Secretion of S-IgA ;204
13.3;III. Autonomimetic Stimulation of pIgR-Mediated IgA Transcytosis;207
13.4;IV. Studies of Reflex IgA Secretion;214
13.5;V. Long-Term Influences of Nerves on S-IgA Secretion;219
13.6;VI. Effects of Nerves on Plasma Cell Production of IgA;221
13.7;VII. Conclusion;223
13.8;References;223
14;Chapter 9. Stress and Secretory Immunity;228
14.1;I. Introduction;229
14.2;II. Saliva as a Model for Mucosal Secretory Defense;230
14.3;III. An Outline of Secretory Immunity;231
14.4;IV. The Neurobiological Basis for Stress-Induced Changes in Salivary Secretory Immunity;233
14.5;V. Stress and Secretory IgA;238
14.6;VI. Stress and Innate Secretory Immunity;255
14.7;VII. Stress and Microbial Colonization Processes;257
14.8;VIII. Future Perspectives;258
14.9;References;260
15;Chapter 10. Cytokines and Depression;270
15.1;I. Introduction;270
15.2;II. Depression and Immune System Dysregulation;271
15.3;III. Neuroendocrine Dysregulation;275
15.4;IV. Relationship between Immune and Neuroendocrine System Changes;277
15.5;V. Effect of Cytokines on Mood;278
15.6;VI. Role of Brain Monoamines;279
15.7;VII. Conclusions;282
15.8;References;283
16;Chapter 11. Immunity and Schizophrenia: Autoimmunity, Cytokines, and Immune Responses;290
16.1;I. Background;290
16.2;II. Autoimmune Diseases and Schizophrenia;292
16.3;III. T and B Lymphocytes in Schizophrenia;296
16.4;IV. HLA Antigens in Schizophrenia;303
16.5;V. HPA Axis in Schizophrenia;304
16.6;VI. Effects of Antipsychotic Medication;305
16.7;VII. Treatment of Schizophrenia with Immunosuppressants;306
16.8;VIII. Vaccine Response;306
16.9;IX. Th1/Th2 Imbalance in Schizophrenia;307
16.10;X. Summary;309
16.11;References;309
17;Chapter 12. Cerebral Lateralization and the Immune System;318
17.1;I. Introduction;318
17.2;II. Opposite Effects of Left- and Right-Cortical Ablations on Immunity;320
17.3;III. Association between Behavioral Lateralization and Immune Reactivity;324
17.4;IV. General Conclusion and Perspectives;332
17.5;References;333
18;Chapter 13. Behavioral Conditioning of the Immune System;340
18.1;I. Introduction;340
18.2;II. Conditioned Immunosuppression Using Cyclosporin A;347
18.3;III. Conditioned Immunopotentiation;350
18.4;IV. Antigen as the Unconditioned Stimulus;353
18.5;V. Human Studies;357
18.6;VI. Conclusions;362
18.7;References;363
19;Chapter 14. Psychological and Neuroendocrine Correlates of Disease Progression;368
19.1;I. Introduction;368
19.2;II. Psychological Correlates Associated with Disease Progression;370
19.3;III. Intervention Studies;378
19.4;IV. Neuroendocrine and Immunological Correlates That Underpin Disease Progression;379
19.5;V. Neuroimmune Alterations Associated with Psychological Interventions;384
19.6;VI. Other Explanatory Mechanisms in Disease Progression;387
19.7;References;388
20;Chapter 15. The Role of Psychological Intervention in Modulating Aspects of Immune Function in Relation to Health and Well-Being;398
20.1;I. Introduction;398
20.2;II. Relaxation Training;399
20.3;III. Guided Imagery of the Immune System;403
20.4;IV. Hypnosis and Immunity;418
20.5;V. Research Directions;421
20.6;References;427
21;Index;434
22;Contents of Recent Volumes;448