Coburn / Bronner Disorders of Mineral Metabolism

Calcium Physiology
1. Auflage 2014
ISBN: 978-1-4832-6535-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 584 Seiten, Web PDF

Disorders of Mineral Metabolism, Volume II: Calcium Physiology is a nine-chapter text that deals with the normal function of calcium, with much emphasis on a host of intracellular functions. This volume discusses the calcium absorption, excretion, and homeostasis, as well as the hormonal modifiers of its metabolism. The role of connective tissue and bone, the major storehouse of body calcium, is reviewed in terms of collagen metabolism. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

Autoren/Hrsg.

Coburn, Jack W.

Bronner, Felix

Inhaltsverzeichnis

1;Front Cover;1
2;Calcium Physiology;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;10
6;Preface;12
7;Contents of Other Volumes;16
8;Chapter 1. The Regulation of the Cellular Functions of Ca2+;18
8.1;I. INTRODUCTION—THE PHYSIOLOGICAL ROLE AND THE BIOLOGICAL FITNESS OF CALCIUM;19
8.2;II. INTRACELLULAR CONCENTRATION OF Ca2+;22
8.3;III. THE TRANSPORT OF Ca2+ ACROSS CELLULAR MEMBRANES—GENERAL CONSIDERATIONS;24
8.4;IV. Ca2+ TRANSPORT ACROSS THE PLASMA MEMBRANE;25
8.5;V. THE TRANSPORT OF Ca2+ BY ENDOPLASMIC AND SARCOPLASMIC RETICULUM;29
8.6;VI. THE TRANSPORT OF Ca2+ BY MITOCHONDRIA;35
8.7;VII. THE CONTROL AND REGULATION OF THE TRANSPORT OFCa2+ ACROSS THE PLASMA AND THE INTRACELLULAR MEMBRANES;42
8.8;VIII. THE SOLUBLE PROTEIN ACTIVATOR (CDR, CALMODULIN) IN THE TRANSMISSION OF THE Ca2+ MESSAGE;45
8.9;IX. SOME GENERAL CONSIDERATIONS ON THE CELLULAR PROCESSES INVOLVING Ca2+;46
8.10;REFERENCES;47
9;Chapter 2. Calcium Homeostasis;60
9.1;I. INTRODUCTION;62
9.2;II. PLASMA CALCIUM;64
9.3;III. SYSTEMS REGULATING CALCIUM HOMEOSTASIS;72
9.4;IV. CALCIUM-REGULATING HORMONES;90
9.5;V. DISTURBANCES OF CALCIUM HOMEOSTASIS;108
9.6;ACKNOWLEDGMENT;113
9.7;REFERENCES;113
10;Chapter 3. Intestinal Absorption of Calcium:Its Assessment, Normal Physiology, and Alterations in Various Disease States;120
10.1;I. INTRODUCTION;121
10.2;II. METHODS FOR MEASUREMENTS OF CALCIUM ABSORPTION;122
10.3;III. MECHANISMS OF INTESTINAL CALCIUM TRANSPORT;128
10.4;IV. HORMONAL EFFECTS ON CALCIUM ABSORPTION;149
10.5;V. PHYSIOLOGIC, DIETARY, AND LOCAL FACTORS AFFECTING CALCIUM ABSORPTION;159
10.6;VI. CONDITIONS WITH REDUCED CALCIUM ABSORPTION;168
10.7;VII. CONDITIONS WITH INCREASED CALCIUM TRANSPORT;182
10.8;ACKNOWLEDGMENTS;185
10.9;REFERENCES;185
11;Chapter 4. Renal Handling of Calcium;206
11.1;I. INTRODUCTION;206
11.2;II. TUBULAR TRANSPORT OF CALCIUM;207
11.3;III. FACTORS AFFECTING URINARY EXCRETION OF CALCIUM;210
11.4;IV. ROLE OF THE KIDNEY IN THE MAINTENANCE OF SERUM CALCIUM;231
11.5;V. URINARY CALCIUM IN PATIENTS WITH RENAL FAILURE;232
11.6;VI. HYPERCALCIURIA;233
11.7;ACKNOWLEDGMENT;239
11.8;REFERENCES;239
12;Chapter 5. Collagen Biosynthesis and Degradation;254
12.1;I. INTRODUCTION;254
12.2;II. EVOLUTIONARY AND TISSUE DISTRIBUTION OF COLLAGENS;255
12.3;III. GENE EXPRESSION OF PROCOLLAGEN AND ITS POSTTRANSLATIONAL ENZYMES;262
12.4;IV. TRANSLATIONAL EXPRESSION OF PROCOLLAGEN;265
12.5;V. INTRACELLULAR PATHWAY OF PROCOLLAGEN TRANSLOCATION;270
12.6;VI. EXTRACELLULAR POSTTRANSLATIONAL MODIFICATIONS;272
12.7;VII. FIBRIL FORMATION AND MATURATION;273
12.8;VIII. COLLAGEN DEGRADATION;274
12.9;IX. BIOCHEMICAL AND MOLECULAR ASPECTS OF COLLAGEN ALTERATIONS IN DISEASE PROCESSES;276
12.10;REFERENCES;278
13;Chapter 6. Parathyroid Hormone;288
13.1;I. INTRODUCTION;289
13.2;II. CHEMISTRY OF PARATHYROID HORMONE;289
13.3;III. BIOSYNTHESIS AND SECRETION OF PARATHYROID HORMONE;293
13.4;IV. METABOLISM OF PARATHYROID HORMONE;305
13.5;V. BIOLOGICAL EFFECTS OF PARATHYROID HORMONE;309
13.6;VI. MEASUREMENTS OF PARATHYROID HORMONE LEVELS;316
13.7;VII. PARATHYROID HORMONE IN NORMAL SUBJECTS AND INDISORDERS OF MINERAL METABOLISM;321
13.8;ACKNOWLEDGMENTS;345
13.9;REFERENCES;345
14;Chapter 7. Vitamin D: Metabolism, Actions,and Disease States;376
14.1;I. INTRODUCTION;377
14.2;II. PHYSIOLOGIC EFFECTS OF VITAMIN D;378
14.3;III. METABOLISM OF VITAMIN D;382
14.4;IV. BIOCHEMICAL MECHANISM OF ACTION IN TARGETTISSUES;390
14.5;V. CLINICALLY RELEVANT ASSAYS FOR VITAMIN DMETABOLITES;396
14.6;VI. DISORDERS OF CALCIUM AND PHOSPHORUS METABOLISM RELATED TO ABERRATIONS IN THE AVAILABILITY, METABOLISM, OR EXPRESSION OF VITAMIN D;406
14.7;VII. CONCLUSIONS;431
14.8;REFERENCES;431
15;Chapter 8. Calcitonin Secretion;450
15.1;I. CALCITONIN;450
15.2;II. PHYSIOLOGY OF CALCITONIN;460
15.3;III. DISORDERS OF CALCITONIN SECRETION;463
15.4;IV. THERAPEUTIC APPLICATIONS OF CALCITONIN;481
15.5;ACKNOWLEDGMENTS;483
15.6;REFERENCES;483
16;Chapter 9. Hormonal Modifiers of Mineral Metabolism Other Than Parathyroid Hormone, Vitamin D,and Calcitonin;498
16.1;I. ADRENAL GLUCOCORTICOIDS;499
16.2;II. GONADAL STEROIDS;509
16.3;III. THYROID HORMONE;517
16.4;IV. GROWTH HORMONE;525
16.5;V. PROLACTIN;532
16.6;VI. INSULIN;533
16.7;VII. GLUCAGON;537
16.8;VIII. GASTROINTESTINAL HORMONES;540
16.9;IX. EPINEPHRINE;542
16.10;X. ERYTHROPOIETIN;544
16.11;XI. SUMMARY;545
16.12;REFERENCES;545
17;Index;574