E-Book, Englisch, 202 Seiten
Conn / Kordon / Christen Insights into Receptor Function and New Drug Development Targets
1. Auflage 2006
ISBN: 978-3-540-34447-6
Verlag: Springer Berlin Heidelberg
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 202 Seiten
Reihe: Research and Perspectives in Endocrine Interactions
ISBN: 978-3-540-34447-6
Verlag: Springer Berlin Heidelberg
Format: PDF
Kopierschutz: 1 - PDF Watermark
This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
Autoren/Hrsg.
Weitere Infos & Material
1;Introduction;5
2;Table of Contents;7
3;List of Contributors;9
4;Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE;16
5;Functional Rescue of Misfolded Receptor Mutants;38
6;Obesity-relatedmutations of leptin and melanocortin receptors;50
7;cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management;68
8;Central Neuropeptide Receptors Involved inWater Balance: Application to Apelin;94
9;Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity;108
10;Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?;120
11;Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists;132
12;Mutations in G proteins and G protein-coupled receptors in human endocrine diseases;154
13;Amolecular dissection of the glycoprotein hormone receptors;166
14;Receptor Tyrosine Kinases as Targets for Cancer Therapy Development;182
15;Targets for pituitary tumor therapy;194
16;The endogenous cannabinoid system in the control of food intake and energy balance;204
17;Subject Index;216
