E-Book, Englisch, 408 Seiten
Dawson Parkinson's Disease
Erscheinungsjahr 2013
ISBN: 978-1-4200-1922-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Genetics and Pathogenesis
E-Book, Englisch, 408 Seiten
Reihe: Neurological Disease and Therapy
ISBN: 978-1-4200-1922-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, this reference spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. This guide will review the major aspects of the disease including motoric and pathologic features, and autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations, as well as provide an in-depth review of genetic considerations. With contributions by recognized experts on the topic, this source will address the pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.
Zielgruppe
Neurologists, clinical neuroscientists, neurogeneticists, and graduate students in these disciplines.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism. Genetic Risk Factors for PD.
PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's Disease.
The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease. ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C. Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's Disease. Rotenone Model. Drug Trials in Animal Models of PD