Della Corte / Huxtable / Sgaragli Taurine 4

Taurine and Excitable Tissues
Erscheinungsjahr 2005
ISBN: 978-0-306-46838-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 483, 652 Seiten, eBook

Reihe: Advances in Experimental Medicine and Biology

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Zielgruppe

Research

Autoren/Hrsg.

Della Corte, Laura

Huxtable, Ryan J.

Sgaragli, Giampietro

Tipton, Keith F.

Inhaltsverzeichnis

Keynote Presentation.- Appreciations.- Plenary Presentations.- Basic Aspects and Peripheral Actions of Taurine.- Metabolic and Nutritional Aspects.- Taurine in the CNS.- Taurine Analogues and Metals: Health Care Aspects.- Taurine and Vision.- Taurine and Cell Homeostatic Mechanisms.- Clinical Aspects.