Dilson J.E Muscle Biophysics

From Molecules to Cells
1. Auflage 2010
ISBN: 978-1-4419-6366-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 354 Seiten

Reihe: Advances in Experimental Medicine and Biology

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Dilson J.E, Rassier

Inhaltsverzeichnis

Striated Muscles: From Molecules to Cells.- Contractile Performance of Striated Muscle.- Energy Economy in the Actomyosin Interaction: Lessons from Simple Models.- A Strain-Dependency of Myosin Off-Rate Must Be Sensitive to Frequency to Predict the B-Process of Sinusoidal Analysis.- Electron Microscopic Visualization of the Cross-Bridge Movement Coupled with ATP Hydrolysis in Muscle Thick Filaments in Aqueous Solution, Reminiscences and Future Prospects.- Role of Titin in Skeletal Muscle Function and Disease.- Contractile Characteristics of Sarcomeres Arranged in Series or Mechanically Isolated from Myofibrils.- The Force–Length Relationship of Mechanically Isolated Sarcomeres.- Extraction and Replacement of the Tropomyosin–Troponin Complex in Isolated Myofibrils.- Stretch and Shortening of Skeletal Muscles Activated Along the Ascending Limb of the Force–Length Relation.- Cross-Bridge Properties in Single Intact Frog Fibers Studied by Fast Stretches.- Crossbridge and Non-crossbridge Contributions to Force in Shortening and Lengthening Muscle.- Short-Range Mechanical Properties of Skeletal and Cardiac Muscles.- Crossbridge Mechanism(s) Examined by Temperature Perturbation Studies on Muscle.- Efficiency of Cross-Bridges and Mitochondria in Mouse Cardiac Muscle.- Mechanisms of Skeletal Muscle Weakness.- Stretch-Induced Membrane Damage in Muscle: Comparison of Wild-Type and mdx Mice.- Cellular and Whole Muscle Studies of Activity Dependent Potentiation.