Donaldson / Borm Particle Toxicology

Erscheinungsjahr 2006
ISBN: 978-1-4200-0314-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 456 Seiten

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences.  Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of “dose” dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles.

Zielgruppe

Toxicologists, inhalation toxicologists, cell biologists, physicists, and environmental health professionals

Autoren/Hrsg.

Donaldson, Ken

Borm, Paul

Fachgebiete

• Naturwissenschaften Biowissenschaften Toxikologie

Inhaltsverzeichnis

An Introduction to Particle Toxicology: From Coal Mining
to Nanotechnology, P. J. A. Borm and K. Donaldson
Mineralogy and Structure of Pathogenic Particles, T. Jones and K. BéruBé
Particle Dosimetry: Deposition and Clearance from the Respiratory Tract and Translocation towards Extra-Pulmonary Sites, W. G. Kreyling, G. Oberdorster, W. Möller, and M. Semmler-Behnke
Particulate Air Pollutants and Small Airway Remodeling, A. Churg
Particle-Mediated Extracellular Oxidative Stress in the Lung, F. J. Kelly and I. S. Mudway
Particles and Cellular Oxidative and Nitrosative Stress, D. W. Porter, S. S. Leonard, and V. Castranova
Interaction of Particles with Membranes, B. Rothen-Rutishauser, S. Schürch, and P. Gehr
 Particle-Associated Metals and Oxidative Stress in Signaling, J. M. Samet and A. J. Ghio
Proinflammatory Effects of Particles on Macrophages and Epithelial Cells, V. Stone, P. G. Barlow, G. R. Hutchinson, and D. M. Brown
Cell-Signaling Pathways Elicited by Particulates, J. E. Levis and B. T. Mossman
Particle-Associated Organics and Proinflammatory Signaling, F. Marano, S. Boland, and A. Baeza-Squiban
The Asbestos Model of Interstitial Pulmonary Fibrosis: TNF-a and TGF-b1 as Mediators of Asbestos-Induced Lung Fibrogenesis, D. E. Sullivan and A. R. Brody
Effects of Particles on the Immune System, I. Gilmour, T. Stevens, and R. K. Saxena
Effects of Particles on the Cardiovascular System, N. Mills, D. E. Newby, W. MacNee, and K. Donaldson
Susceptibility to Particle Effects, S. R. Kleeberger and R. Howden
Genotoxic Effects of Particles, R. P. F. Schins and T. K. Hei
Approaches to the Toxicological Testing of Particles, K. Donaldson, S. Faux, P. Borm, and V. Stone
Models for Testing the Pulmonary Toxicity of Particles: Lung Bioassay Screening Studies in Male Rats with a New Formulation of TiO2 Particulates, D. B. Warheit, K. L. Reed, and C. M. Sayes
Air Pollution and Human Brain Pathology: A Role for Air Pollutants in the Pathogensis of Alzheimer’s Disease, L. Calderón-Garcidueñas and W. Reed
Biologically-Based Lung Dosimetry and Exposure-Dose-Response Models for Poorly Soluble Inhaled Particles, L. Tran and E. Kuempel
Nanoparticles in Medicine, P. J. A. Borm and D. Muller-Schulte
The Toxicology of Inhaled Particles: Summing Up an Emerging Conceptual Framework, K. Donaldson, L. Tran, and P. Borm Index