Entschladen / Zänker Cell Migration: Signalling and Mechanisms

1. Auflage 2009
ISBN: 978-3-8055-9322-9
Verlag: S. Karger
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 2, 184 Seiten

Reihe: Translational Research in Biomedicine

Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis.

Autoren/Hrsg.

Entschladen, F.

Zänker, K.S.

Weitere Mitwirkende

Chan, S.H.H.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Foreword;7
4;Preface;9
5;The Migrating Cell;10
5.1;Abstract;10
5.2;Acknowledgement;14
5.3;References;14
6;Stem Cell Migration in Health and Disease;16
6.1;Abstract;16
6.2;HSC/HSPC Mobilization;19
6.3;HSC/HSPC Homing;21
6.4;The SDF-1a/CXCR4 Axis;23
6.5;Modulation of the SDF-1a-Induced Migration of HSPCs;26
6.6;Cancer Stem Cell Migration;27
6.7;Conclusion;30
6.8;Acknowledgements;31
6.9;References;31
7;Leukocyte Motility and Human Disease;37
7.1;Abstract;37
7.2;Basic Steps of Cell Movement;37
7.3;External Factors That Regulate Cell Migration;38
7.4;Cell Signaling during Neutrophil-Directed Migration;38
7.5;Neutrophil Motility in Disease;43
7.6;Neutrophil Motility in Chronic Inflammatory Disease;44
7.7;Conclusion;45
7.8;References;46
8;Coordination of Leukocyte Polarity and Migration;49
8.1;Abstract;49
8.2;Leukocyte Polarization;49
8.3;Sensing Chemotactic Gradients;52
8.4;Establishment of Two Poles: Front-Back Coordination;54
8.5;Microtubule Connection: The Lost Link?;56
8.6;Segregated Signalling Domains in Polarized Lymphocytes;58
8.7;Concluding Remarks;60
8.8;References;60
9;Positioning Phosphoinositide 3-Kinase in Chemokine and Antigen-Dependent T-Lymphocyte Navigation Mechanisms;63
9.1;Abstract;63
9.2;Class 1 PI3Ks: An Overview;64
9.3;A Role for PI3K in Cell Migration: The Story So Far;65
9.4;Evidence for PI3K-Dependent and -Independent T-Lymphocyte Directional Migration;66
9.5;Role of PI3K in T-Lymphocyte Homing and Migration in vivo: Lessons from Gene-Targeted from Mice;67
9.6;Role of PI3K in Interstitial T-Lymphocyte Motility;68
9.7;Antigen Recognition by the TCR and Costimulatory Receptors Influence T-Cell Trafficking;68
9.8;PI3K Influences Effector T-Cell Migration at Transcriptional and Post-Translational Levels;70
9.9;Conclusions;70
9.10;Acknowledgement;72
9.11;References;72
10;Migration of Functionally Specialized T-Helper Cells: TFH Cells, Th17 Cells and FoxP3+ T Cells;76
10.1;Abstract;76
10.2;Migration and Trafficking Receptors of T Cells;77
10.3;Generation of the Functionally Specialized T-Helper Cell Subsets;78
10.4;Migration and Function of TFH Cells;79
10.5;Migration and Function of Th17 Cells;82
10.6;Migration and Function of FoxP3+ Cells;84
10.7;Concluding Remarks;85
10.8;References;86
11;ADAMs and Ectodomain Proteolytic Shedding in Leukocyte and Tumour Cell Migration;92
11.1;Abstract;92
11.2;Leukocyte Trafficking;93
11.3;ADAMs and Ectodomain Shedding of Leukocyte Receptors;95
11.4;CD44 Shedding and T-Cell Recruitment in Autoimmune Lesions;100
11.5;ADAMs and Ectodomain Shedding of Endothelial Receptors;100
11.6;Crossing the Basement Membrane and Interstitial Migration;101
11.7;ADAMs and Ectodomain Shedding in Tumour Cell Extravasation;102
11.8;How, Where and When Are ADAMs Activated;102
11.9;Regulation of ADAM10 and 17 Proteolytic Activity;103
11.10;Regulation of ADAM15 Function by Interacting Kinases;104
11.11;Conclusions and Future Prospects;105
11.12;References;106
12;Guided Tour of Cell Migration: Signals and Pathways;111
12.1;Abstract;111
12.2;Induction of Migratory Activity by Extracellular Signal Substances;112
12.3;Pathways Leading to Cell Migration (Cytokines and Neurotransmitters);118
12.4;Conclusion;123
12.5;Acknowledgement;123
12.6;References;123
13;Regulation of the E-Cadherin Adhesion Complex in Tumor Cell Migration and Invasion;129
13.1;Abstract;129
13.2;E-Cadherin-Mediated Adherens Junctions;130
13.3;Regulation of E-Cadherin Gene Expression;131
13.4;Regulation of the E-Cadherin Adhesion Complex by ß-Catenin;134
13.5;Regulation of Cell-Cell Adhesion by the Cellular Microenvironment;136
13.6;Regulation of Cell-Cell Adhesion by p120ctn and GTPases;138
13.7;References;140
14;The Cytoskeletal Connection: Understanding Adaptor Proteins;145
14.1;Abstract;145
14.2;The Cell Adhesion Complex: A Simplistic View;145
14.3;Proteins: Biochemical Characteristics and Molecular Architecture;147
14.4;Cell Adhesion Complex: Protein Properties in the Cellular Context;150
14.5;Cell Migration: Regulation of Adaptor Proteins during Contact Turnover;156
14.6;Organism: Specific Tasks in Tissues and Organs;164
14.7;Concluding Remarks;165
14.8;Acknowledgements;166
14.9;References;166
15;Locomotor Force Generation by Myosins;172
15.1;Abstract;172
15.2;The Myosin Superfamily;172
15.3;Myosin I;175
15.4;Myosin II;175
15.5;Myosin V;176
15.6;Myosin VI;178
15.7;Myosin VII;178
15.8;Myosin X;178
15.9;Concluding Remarks;179
15.10;Acknowledgement;179
15.11;References;179
16;Author Index;182
17;Subject Index;183