Fialho / Chakrabarty Emerging Cancer Therapy

Microbial Approaches and Biotechnological Tools
1. Auflage 2010
ISBN: 978-0-470-62651-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 448 Seiten, E-Book

Reihe: Wiley Series on Biotechnology

Explores current and emerging applications of microbes ascancer-fighting agents
Today, treatment options for cancer patients typically includesurgery, radiation therapy, immunotherapy, and chemotherapy. Whilethese therapies have saved lives and reduced pain and suffering,cancer still takes millions of lives every year around the world.In recent years, researchers have been working on a new strategy:developing microbes and microbial products that specifically attackcancer cells.
This book breaks new ground in emerging cancer treatmentmodalities by presenting recent advances in the use ofmicroorganisms and viruses as well as their products in cancertherapy. Seventeen chapters review the application of livemicroorganisms, high and low molecular weight products derived frommicroorganisms, and microbial products fused to cancer-targetingmolecules. In addition, the book highlights the benefits of amulti-target approach to destroy cancer cells. Readers will notonly discover the results and significance of basic and clinicalresearch, but also encouraging results from clinical trials.
Emerging Cancer Therapy is divided into threesections:
* Section 1: Live/Attenuated Bacteria and Viruses asAnticancer Agents
* Section 2: Bacterial Products as Anticancer Agents
* Section 3: Patents on Bacteria/Bacterial Products asAnticancer Agents
With chapters written by leading pioneers in microbial, biotech,and cancer research, Emerging Cancer Therapy is recommendedfor biotechnologists, microbiologists, clinical oncologists,medicinal chemists, and biochemists. Readers will not only learnthe tremendous potential of microbial and biotechnologicalapproaches to cancer therapy, but also discover new directions ofresearch for effective drug discovery and development.

Autoren/Hrsg.

Fialho, Arsenio

Chakrabarty, Ananda

Inhaltsverzeichnis

PREFACE.
CONTRIBUTORS.
PART I LIVE/ATTENUATED BACTERIA AND VIRUSES AS ANTICANCERAGENTS.
1 Salmonella Typhimurium Mutants Selected to GrowOnly in Tumors to Eradicate Them in Nude Mouse Models (Robert M.Hoffman).
2 The Use of Living Listeria Monocytogenes as anActive Immunotherapy for the Treatment of Cancer (JohnRothman, Anu Wallecha, Paulo Cesar Maciag, Sandra Rivera, VafaShahabi, and Yvonne Paterson).
3 Bacillus Calmette-Guerin (BCG) for UrothelialCarcinoma of the Bladder (Timothy P. Kresowik and Thomas S.Griffith).
4 Live Clostridia: A Powerful Tool in TumorBiotherapy (Lieve Van Mellaert, Ming Q Wei, and JozefAnné).
5 Bifi dobacterium as a Delivery System of FunctionalGenes for Cancer Gene Therapy (Geng-Feng Fu, Yan Yin, Bi Hu,and Gen-Xing Xu).
6 Replication-Selective Viruses for the Treatment ofCancer (Padma Sampath and Steve H. Thorne).
7 Engineering Herpes Simplex Virus for Cancer OncolyticVirotherapy (Jason S. Buhrman, Tooba A. Cheema, and GiuliaFulci).
PART II BACTERIAL PRODUCTS AS ANTICANCER AGENTS.
8 Promiscuous Anticancer Drugs from Pathogenic Bacteria:Rational Versus Intelligent Drug Design (Arsénio M.Fialho and Ananda M. Chakrabarty).
9 Arginine Deiminase and Cancer Therapy (Lynn Feun, M.Tien Kuo, Ming You, Chung Jing Wu, Medhi Wangpaichitr, and NiramolSavaraj).
10 Cytosine Deaminase/5-Fluorocytosine Molecular CancerChemotherapy (Sergey A. Kaliberov and Donald J.Buchsbaum).
11 Bacterial Proteins Against Metastasis (Anna MariaElisabeth Walenkamp).
12 Pseudomonas Exotoxin A-Based Immunotoxins forTargeted Cancer Therapy (Philipp Wolf and UrsulaElsässer-Beile).
13 Denileukin Diftitox in Novel Cancer Therapy(Lin-Chi Chen and Nam H. Dang).
14 The Application of Cationic Antimicrobial Peptides inCancer Treatment: Laboratory Investigations and ClinicalPotential (Ashley L. Hilchie and David W.Hoskin).
15 Prodiginines and Their Potential Utility as ProapoptoticAnticancer Agents (Neil R. Williamson, Suresh Chawrai,Finian J. Leeper, and George P.C. Salmond).
16 Farnesyltransferase Inhibitors of Microbial Origins inCancer Therapy (Jingxuan Pan and Sai-Ching JimYeung).
17 The Use of RNA and CpG DNA as Nucleic Acid-BasedTherapeutics (Jörg Vollmer).
PART III PATENTS ON BACTERIA/BACTERIAL PRODUCTS AS ANTICANCERAGENTS.
18 The Role and Importance of Intellectual PropertyGeneration and Protection in Drug Development (ArsénioM. Fialho and Ananda M. Chakrabarty).
INDEX.

Über Autor(innen)

ARSÉNIO FIALHO, PhD, is Associate Professor in theDepartment of Chemical and Biological Engineering and PrincipalInvestigator for the Institute of Biotechnology and Bioengineeringin the Instituto Superior Técnico at the UniversidadeTécnica de Lisboa, Portugal. His current scientific interestsare focused on the study of bacterial proteins, such as azurin andLaz, as novel multi-targeted drug candidates with anticanceractivities. He is the author or coauthor of more than fifty papersin peer-reviewed scientific journals and, during the last fouryears, became the holder of five U.S. patents. Dr. Fialho teachescourses in biochemistry, molecular biology, and bioinformatics.
ANANDA CHAKRABARTY, PhD, is Distinguished UniversityProfessor in the Department of Microbiology and Immunology at theUniversity of Illinois College of Medicine at Chicago. In additionto more than 250 research publications, he has secured nine U.S.patents during the last four years on azurin and Laz, two bacterialproteins with anticancer, anti-viral and anti-parasitic activities.He also is the recipient of a patent on the first life form, agenetically manipulated pseudomonad designed to degrade multiplehydrocarbons present in crude oil, as decided by the U.S. SupremeCourt in 1980 in the celebrated court case Diamond v.Chakrabarty.