Fields / Jaenisch Animal Virus Genetics

1. Auflage 2013
ISBN: 978-1-4832-7261-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 856 Seiten, Web PDF

Animal Virus Genetics is a collection of scientific presentations of the ICN-UCLA Symposia on Molecular and Cellular Biology, held at the University of California, Los Angeles in 1980. The papers in the compendium focus on the basic genetic model systems; the uses of genetic approaches to study basic problems in molecular biology; and on the increasing application of genetic systems to the study of more complex viral-host interactions such as viral virulence and persistence. Microbiologists, cellular biologists, and virologists will find the book insightful.

Autoren/Hrsg.

Fields, Bernard N.

Jaenisch, Rudolf

Inhaltsverzeichnis

1;Front Cover;1
2;Animal Virus Genetics;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;14
6;PREFACE;26
7;CHAPTER 1. IS-ELEMENTS AND TRANSPOSONS;28
7.1;A. Transposition And Evolution;28
7.2;B. Properties of IS-Elements And Transposons;30
7.3;C. The Structure And Transposition of IS-Elements;31
7.4;D. The Specificity of Transposition;33
7.5;E. Future Questions;33
7.6;ACKNOWLEDGEMENT;34
7.7;REFERENCES;35
8;CHAPTER 2. A MODULAR THEORY OF VIRUS EVOLUTION;38
8.1;INTRODUCTION;38
8.2;RESULTS AND DISCUSSION;39
8.3;ACKNOWLEDGMENTS;46
8.4;REFERENCES;46
9;CHAPTER 3. MOLECULAR CLONING OF THE HUMAN CYTOMEGALOVIRUS GENOME (STRAIN AD169);48
9.1;INTRODUCTION;48
9.2;RESULTS;50
9.3;DISCUSSION;61
9.4;ACKNOWLEDGMENTS;63
9.5;REFERENCES;63
10;CHAPTER 4. STRUCTURAL ORGANIZATION OF THE DNA MOLECULES FROM HUMAN CYTOMEGALOVIRUS;66
10.1;INTRODUCTION;67
10.2;RESULTS;68
10.3;DISCUSSION;79
10.4;REFERENCES;81
11;CHAPTER 5. THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES;84
11.1;INTRODUCTION;84
11.2;CLONING AND SEQUENCE ANALYSIS OF THE HEPATITIS B VIRUS;86
11.3;IDENTIFICATION OF POLYPEPTIDE CODING REGIONS;86
11.4;SURFACE ANTIGEN GENE;90
11.5;THE CORE GENE;90
11.6;POSSIBLE CODING REGIONS A AND B;91
11.7;GENERAL FEATURES OF THE VIRUS;93
11.8;ACKNOWLEDGEMENTS;95
11.9;REFERENCES;95
12;CHAPTER 6. CORRELATING GENETIC MUTATIONS OF A BACULOVIRUS WITH THE PHYSICAL MAP OF THE DNA GENOME;98
12.1;INTRODUCTION;98
12.2;RESULTS;101
12.3;DISCUSSION;105
12.4;ACKNOWLEDGEMENTS;106
12.5;REFERENCES;106
13;CHAPTER 7. ANALYSIS OF VSV GLYCOPROTEIN STRUCTURE AND GENOME STRUCTURE USING CLONED DNA;108
13.1;INTRODUCTION;109
13.2;RESULTS AND DISCUSSION;110
13.3;ACKNOWLEDGMENTS;118
13.4;REFERENCES;118
14;CHAPTER 8. RIBOSCME BINDING TO POLIO VIRUS RNA;122
14.1;INTRODUCTION;122
14.2;METHODS;123
14.3;RESULTS;123
14.4;DISCUSSION;129
14.5;ACKNOWLEDGMENTS;130
14.6;REFERENCES;130
15;CHAPTER 9. SEQUENCE ANALYSIS OF THE POLIOVIRUS GENOME AND MAPPING OF THE GENOME-LINKED PROTEIN1;132
15.1;INTRODUCTION;132
15.2;RESULTS;134
15.3;DISCUSSION;139
15.4;REFERENCES;142
16;CHAPTER 10. REOVIRUS GENOME RNA: COMMON 3'-TERMINAL NUCLEOTIDE SEQUENCES AND ASSIGNMENT OF mRNA RIBOSOME BINDING SITES TO VIRION GENOME SEGMENTS;144
16.1;INTRODUCTION;144
16.2;RESULTS;146
16.3;DISCUSSION;152
16.4;ACKNOWLEDGMENTS;152
16.5;REFERENCES;153
17;CHAPTER 11. TERMINAL SEQUENCE HOMOLOGIES IN REOVIRUS GENES;156
17.1;INTRODUCTION;157
17.2;METHODS AND RESULTS;158
17.3;THE SEQUENCES OF THE SI GENES;161
17.4;THE IDENTITY OF REOVIRUS PLUS STRANDS AND REOVIRUS MESSENGER RNA;163
17.5;THE SEQUENCES OF THE S2 GENES;169
17.6;ACKNOWLEDGMENTS;169
17.7;REFERENCES;169
18;CHAPTER 12. ATTEMPTS AT THE MOLECULAR CLONING OF A TRANSFORMING ALLELE FROM CHEMICALLY TRANSFORMED MOUSE CELLS;172
18.1;INTRODUCTION;172
18.2;EXTENSION OF THE TRANSFECTION PROCEDURE TO STUDY OF DNAS FROM CHEMICALLY TRANSFORMED CELLS;174
18.3;A STRATEGY FOR THE MOLECULAR CLONING OF THE ALLELE FOR TRANSFORMATION;175
18.4;CONCLUSIONS;179
18.5;REFERENCES;180
19;CHAPTER 13. MECHANISMS OF DNA-MEDIATED TRANSFORMATION IN ANIMAL CELLS ;182
19.1;INTRODUCTION;182
19.2;RESULTS;184
19.3;DISCUSSION;193
19.4;ACKNOWLEDGEMENTS;194
19.5;REFERENCES;195
20;CHAPTER 14. CHROMOSOMAL MAPPING OF ECOTROPIC AND XENOTROPIC LEUKEMIA VIRUS-INDUCING LOCI IN THE MOUSE;198
20.1;REFERENCES;202
21;CHAPTER 15. CORRELATION BETWEEN THE DEVELOPMENT OF MURINE MAMMARY CANCER AND THE SEGREGATION OF ENDOGENOUS GENES;204
21.1;INTRODUCTION;205
21.2;RESULTS;205
21.3;DISCUSSION;211
21.4;ACKNOWLEDGMENTS;212
21.5;REFERENCES;212
22;CHAPTER 16. A STUDY OF THE ENDOGENOUS MOLONEY RELATED SEQUENCES OF MICE;214
22.1;INTRODUCTION;214
22.2;METHODS;214
22.3;RESULTS;215
22.4;DISCUSSION;220
22.5;REFERENCES;222
23;CHAPTER 17. STRUCTURAL AND GENETIC RELATIONSHIPS BETWEEN AN ENDOGENOUS RETROVIRUS (M432) OF MUS CERVICOLOR AND INTRACISTERNAL A–PARTICLES OF MUS MUSCULUS;224
23.1;INTRODUCTION;224
23.2;RESULTS;226
23.3;DISCUSSION;231
23.4;REFERENCES;233
24;CHAPTER 18. GENETIC CONTROL OF MuLV EXPRESSION AND SPONTANEOUS LYMPHOMA IN CROSSES OF HIGH- AND LOW-LYMPHOMA STRAINS;234
24.1;ECOTROPIC MuLV AND LYMPHOMA;235
24.2;XENOTROPIC MuLV AND LYMPHOMA;237
24.3;FURTHER HIGH- X LOW-LYMPHOMA CROSSES: LYMPHOMA INCIDENCE;238
24.4;FURTHER HIGH- X LOW-LYMPHOMA CROSSES: MuLV EXPRESSION;240
24.5;REFERENCES;241
25;CHAPTER 19. THE ANOMALOUS ANTIBODY RESPONSE OF HYBRID MICE TO IMMUNIZATION WITH AN ABELSON VIRUS LYMPHOMA;244
25.1;INTRODUCTION;244
25.2;METHODS;245
25.3;RESULTS;245
25.4;DISCUSSION;248
25.5;REFERENCE;248
26;CHAPTER 20. URINE LEUKEMIA VIRUS RESTRICTION GENE, SEGREGATES IN LEUKEMIA-PRONE WILD MICE;250
26.1;INTRODUCTION;251
26.2;METHODS;251
26.3;RESULTS;251
26.4;DISCUSSION;258
26.5;REFERENCES;258
27;CHAPTER 21. GENETIC CONTROL OF RESISTANCE OF MOUSE HEPATITIS VIRUS, STRAIN JHM, INDUCED ENCEPHALOMYELITIS;260
27.1;INTRODUCTION;260
27.2;MATERIALS AND METHODS;261
27.3;RESULTS;261
27.4;DISCUSSION;263
27.5;ACKNOWLEDGEMENTS;265
27.6;REFERENCES;265
28;CHAPTER 22. LEARNING ABOUT THE REPLICATION OF RETROVIRUSES FROM A SINGLE CLONED PROVIRUS OF MOUSE MAMMARY TUMOR VIRUS;268
28.1;INTRODUCTION: THE REPLICATION OF RETROVIRUSES;269
28.2;PORTRAIT OF AN MMTV PROVIRUS;272
28.3;IMPLICATIONS OF PROVIRAL STRUCTURE FOR MECHANISMS OF INTEGRATION AND TRANSCRIPTIONAL REGULATION;275
28.4;SIGNIFICANCE OF THE STRUCTURAL SIMILARITIES BETWEEN PROVIRUSES AND TRANSPOSABLE ELEMENTS;276
28.5;ACKNOWLEDGEMENTS;278
28.6;REFERENCES;278
29;CHAPTER 23. OBSERVATIONS ON THE DNA SEQUENCE OF THE EXTENDED TERMINAL REDUNDANCY AND ADJACENT HOST SEQUENCES FOR INTEGRATED MOUSE MAMMARY TUMOR VIRUS;282
29.1;INTRODUCTION;282
29.2;METHODS;284
29.3;RESULTS;285
29.4;DISCUSSION;285
29.5;ACKNOWLEDGEMENTS;289
29.6;REFERENCES;289
30;CHAPTER 24. DERIVATION OF THREE MOUSE STRAINS CARRYING MOLONEY LEUKEMIA VIRUS IN THEIR GERM LINE AT DIFFERENT GENETIC LOCI;292
30.1;INTRODUCTION;292
30.2;MATERIALS AND METHODS;293
30.3;RESULTS;294
30.4;CONCLUSIONS;302
30.5;ACKNOWLEDGMENTS;304
30.6;REFERENCES;305
31;CHAPTER 25. A HUMAN HEPATOMA CELL LINE CONTAINS HEPATITIS B DNA AND RNA SEQUENCES;308
31.1;INTRODUCTION;308
31.2;METHODS;309
31.3;RESULTS;311
31.4;DISCUSSION;317
31.5;ACKNOWLEDGEMENTS;319
31.6;REFERENCES;319
32;CHAPTER 26. POLYOMA VIRUS HR-T GENE PRODUCTS;322
32.1;INTRODUCTION;322
32.2;RESULTS;324
32.3;DISCUSSION;331
32.4;ACKNOWLEDGMENTS;333
32.5;REFERENCES;333
33;CHAPTER 27. COMPLEMENTATION STUDIES WITH TRANSFORMATION DEFECTIVE MUTANTS OF POLYOMA VIRUS;336
33.1;INTRODUCTION;336
33.2;RESULTS;337
33.3;DISCUSSION;340
33.4;ACKNOWLEDGMENTS;342
33.5;REFERENCES;342
34;CHAPTER 28. ANALYSIS OF ADENOVIRUS INDUCED CELLULAR DNA SYNTHESIS IN A ts MUTANT OF THE CELL CYCLE;344
34.1;INTRODUCTION;344
34.2;METHODS;345
34.3;RESULTS;346
34.4;DISCUSSION;350
34.5;ACKNOWLEDGMENTS;351
34.6;REFERENCES;352
35;CHAPTER 29. REGULATION OF ADENOVIRUS EARLY GENE EXPRESSION;354
35.1;INTRODUCTION;354
35.2;RESULTS;357
35.3;DISCUSSION;361
35.4;ACKNOWLEDGMENTS;364
35.5;REFERENCES;364
36;CHAPTER 30. METHYLATION AND EXPRESSION OF ADENOVIRAL DNA IN INFECTED AND TRANSFORMED CELLS;366
36.1;INTRODUCTION;367
36.2;MATERIALS AND METHODS;368
36.3;RESULTS;369
36.4;DISCUSSION;376
36.5;ACKNOWLEDGMENTS;377
36.6;REFERENCES;378
37;CHAPTER 31. SYNTHESIS OF ADENOVIRUS 2 RNA in vitro: PROPERTIES OF THE MAJOR LATER TRANSCRIPT AND ITS PROMOTER;380
37.1;INTRODUCTION;381
37.2;MATERIALS AND METHODS;382
37.3;RESULTS AND DISCUSSION;382
37.4;ACKNOWLEDGMENTS;393
37.5;REFERENCES;393
38;CHAPTER 32. A GENE FUNCTION OF HERPES SIMPLEX VIRUS REQUIRED FOR EXPRESSION OF ALL EARLY VIRAL GENES;396
38.1;INTRODUCTION;396
38.2;RESULTS AND DISCUSSION;397
38.3;ACKNOWLEDGEMENTS;404
38.4;REFERENCES;404
39;CHAPTER 33. A VARIANT VSV GENERATES DEFECTIVE INTERFERING PARTICLES WITH REPLICASE-LIKE ACTIVITY IN VITRO;406
39.1;INTRODUCTION;406
39.2;RESULTS;407
39.3;DISCUSSION;414
39.4;ACKNOWLEDGMENTS;416
39.5;REFERENCES;416
40;CHAPTER 34. SEPARATION OF FULL LENGTH TRANSCRIPTS AND GENOME RNA PLUS AND MINUS STRANDS FROM CYTOPLASMIC POLYHEDROSIS VIRUS OF BOMBYX MORI;418
40.1;INTRODUCTION;418
40.2;MATERIALS AND METHODS;419
40.3;RESULTS;420
40.4;DISCUSSION;426
40.5;ACKNOWLEDGEMENT;426
40.6;REFERENCES;427
41;CHAPTER 35. DIFFERENTIAL METHYLATION OF ENDOGENOUS AND ACQUIRED MOUSE MAMMARY TUMOR VIRUS-SPECIFIC DNA;428
41.1;INTRODUCTION;428
41.2;RESULTS;430
41.3;DISCUSSION;435
41.4;REFERENCES;436
42;CHAPTER 36. SFFV SPECIFIC GENE EXPRESSION IN INFECTED AND ERYTHROLEUKEMIA CELLS;438
42.1;INTRODUCTION;438
42.2;METHODS;439
42.3;RESULTS;441
42.4;DISCUSSION;448
42.5;ACKNOWLEDGMENTS;449
42.6;REFERENCES;449
43;CHAPTER 37. MOLECULAR GENETICS AND CELL CULTURE ASSAYS FOR HELPER-INDEPENDENT AND REPLICATION-DEFECTIVE COMPONENTS OF THE FRIEND VIRUS COMPLEX;452
43.1;INTRODUCTION;452
43.2;RESULTS;453
43.3;DISCUSSION;467
43.4;REFERENCES;468
44;CHAPTER 38. VIRAL ENVELOPE GENES AND c REGIONS IN NON-ACUTE AVIAN LEUKOSIS VIRUS ASSOCIATED DISEASE;470
44.1;INTRODUCTION;471
44.2;RESULTS;472
44.3;DISCUSSION;477
44.4;ACKNOWLEDGEMENTS;478
44.5;REFERENCES;478
45;CHAPTER 39. TWO REGIONS OF THE MOLONEY LEUKEMIA VIRUS GENOME ARE REQUIRED FOR EFFICIENT TRANSFORMATION BY src/sarc;482
45.1;ABSTRACT;482
45.2;INTRODUCTION;482
45.3;RESULTS AND DISCUSSION;483
45.4;REFERENCES;486
46;CHAPTER 40. MOLECULAR CLONING OF MOLONEY MOUSE SARCOMA VIRUS SPECIFIC SEQUENCES FROM UNINFECTED MOUSE CELLS;488
46.1;ABSTRACT;488
46.2;INTRODUCTION;488
46.3;RESULTS;489
46.4;DISCUSSION;496
46.5;ACKNOWLEDGMENTS;497
46.6;REFERENCES;497
47;CHAPTER 41. CHARACTERIZATION OF MOLECULARLY CLONED SPLEEN FOCUS-FORMING VIRUS DNA;500
47.1;INTRODUCTION;500
47.2;RESULTS AND DISCUSSION;501
47.3;REFERENCES;509
48;CHAPTER 42. THE NATURE AND ORIGIN OF THE TRANSFORMING GENE OF AVIAN SARCOMA VIRUSES;510
48.1;INTRODUCTION;510
48.2;RESULTS;512
48.3;DISCUSSION;522
48.4;ACKNOWLEDGMENTS;523
48.5;REFERENCES;523
49;CHAPTER 43. PHOSPHORYLATION OF TYROSINE: A MECHANISM OF TRANSFORMATION SHARED BY A NUMBER OF OTHERWISE UNRELATED RNA TUMOR VIRUSES;526
49.1;INTRODUCTION;527
49.2;RESULTS;529
49.3;DISCUSSION;535
49.4;ACKNOWLEDGMENTS;539
49.5;REFERENCES;539
50;CHAPTER 44. PRCII, A NEW TYPE OF AVIAN SARCOMA VIRUS;542
50.1;INTRODUCTION;542
50.2;RESULTS;543
50.3;DISCUSSION;550
50.4;ABBREVIATIONS;552
50.5;ACKNOWLEDGMENT;552
50.6;REFERENCES;552
51;CHAPTER 45. FUJINAMI SARCOMA VIRUS AND SARCOMAGENIC, AVIAN ACUTE LEUKEMIA VIRUSES HAVE SIMILAR GENETIC STRUCTURES;554
51.1;INTRODUCTION;555
51.2;RESULTS;555
51.3;DISCUSSION;563
51.4;ACKNOWLEDGMENTS;565
51.5;REFERENCES;565
52;CHAPTER 46. A MODEL FOR FOCMA EXPRESSION IN CELLS TRANSFORMED BY FELINE LEUKEMIA AND SARCOMA VIRUSES;568
52.1;INTRODUCTION;568
52.2;RESULTS AND DISCUSSION;570
52.3;REFERENCES;576
53;CHAPTER 47. TRANSFORMATION DEFECTIVE MUTANTS OF AEV AND MC29 AVIAN LEUKEMIA VIRUSES SYNTHESIZE SMALLER GAG-RELATED PROTEINS;578
53.1;INTRODUCTION;578
53.2;RESULTS;579
53.3;DISCUSSION;589
53.4;ACKNOWLEDGMENTS;593
53.5;REFERENCES;593
54;CHAPTER 48. ISOLATION AND CHARACTERIZATION OF PHENOTYPIC REVERTANTS FROM MOLONEY MURINE SARCOMA VIRUS-TRANSFORMED CELLS;596
54.1;ABSTRACT;596
54.2;INTRODUCTION;596
54.3;METHODS;597
54.4;RESULTS;599
54.5;DISCUSSION;603
54.6;ACKNOWLEDGEMENTS;605
54.7;REFERENCES;605
55;CHAPTER 49. GENETICS OF ACYCLOGUANOSINE RESISTANCE AND THE THYMIDINE KINASE GENE IN HSV-1;608
55.1;ABSTRACT;608
55.2;INTRODUCTION;608
55.3;MATERIALS AND METHODS;609
55.4;RESULTS;610
55.5;DISCUSSION;615
55.6;ACKNOWLEDGEMENTS;616
55.7;REFERENCES;617
56;CHAPTER 50. STUDY OF GENETIC VARIABILITY OF VIRUSES THROUGH THE USE OF MONOCLONAL ANTIBODIES;618
56.1;ABSTRACT;618
56.2;INTRODUCTION;618
56.3;ANTINUCLEOCAPSID HYBRIDOMAS;623
56.4;ANALYSIS OF FIELD STRAINS OF RABIES BY MEANS OF ANTINUCLEOCAPSID HYBRIDOMAS;625
56.5;ANTIGLYCOPROTEIN HYBRIDOMAS;628
56.6;VARIANTS OF FIELD STRAINS OF RABIES VIRUS RECOGNIZED BY ANTIGLYCOPROTEIN HYBRIDOMAS;628
56.7;SELECTION OF VARIANTS;631
56.8;THE RANGE OF CROSS-PROTECTION AMONG CVS-VARIANTS SELECTED IN VITRO;632
56.9;REFERENCES;639
57;CHAPTER 51. VESICULAR STOMATITIS VIRUS MORPHOGENESIS IS ACCOMPANIED BY COVALENT PROTEIN MODIFICATIONS;640
57.1;INTRODUCTION;640
57.2;METHODS;640
57.3;RESULTS;641
57.4;DISCUSSION;647
57.5;REFERENCES;648
58;CHAPTER 52. UNCOUPLING OF THE HEMAGGLUTINATING AND NEURAMINIDASE ACTIVITIES OF NEWCASTLE DISEASE VIRUS (NDV);650
58.1;INTRODUCTION;650
58.2;RESULTS;651
58.3;DISCUSSION;657
58.4;ACKNOWLEDGMENTS;658
58.5;REFERENCES;659
59;CHAPTER 53. SUPPRESSION OF TEMPERATURE-SENSITIVE PHENOTYPE IN REOVIRUS: AN ALTERNATE PATHWAY FROM ts TO ts + PHENOTYPE;660
59.1;INTRODUCTION;660
59.2;METHODS;661
59.3;RESULTS;661
59.4;DISCUSSION;666
59.5;REFERENCES;668
60;CHAPTER 54. TRANSLATION PRODUCTS OF THE 124 STRAIN OF MOLONEY MURINE SARCOMA VIRUS (Mo-MuSV) : CHARACTERIZATION OF A 23,000 DALTON CANDIDATE "src' GENE PRODUCT;670
60.1;INTRODUCTION;670
60.2;METHODS;671
60.3;RESULTS;671
60.4;DISCUSSION;679
60.5;ACKNOWLEDGEMENTS;681
60.6;REFERENCES;681
61;CHAPTER 55. CHARACTERIZATION AND GENETIC ANALYSIS OF RETROVIRUS MATURATION: A ROLE FOR Prl80gag-pol;684
61.1;INTRODUCTION;684
61.2;METHODS;684
61.3;RESULTS;685
61.4;SUMMARY;688
61.5;REFERENCES;689
62;CHAPTER 56. THE MOLECULAR BASIS OF REOVIRUS VIRULENCE;690
62.1;MECHANISM OF REOVIRUS VIRULENCE;690
62.2;VIRUS HOST INTERACTION: THE ROLE OF THE S1 dsRNA PRODUCT, THE VIRAL HEMAGGLUTININ;693
62.3;SUMMARY OF FUNCTIONS OF THE VIRAL HA;697
62.4;VIRUS HOST INTERACTION: THE ROLE OF THE M2 dsRNA PRODUCT, THE µlC POLYPEPTIDE;697
62.5;SUMMARY;698
62.6;ACKNOWLEDGMENTS;698
62.7;REFERENCES;698
63;CHAPTER 57. A GENETIC APPROACH TO CYTOPATHOGENICITY, VIRUS SPREAD, AND VIRULENCE OF NEWCASTLE DISEASE VIRUS (NDV);700
63.1;INTRODUCTION;700
63.2;RESULTS;701
63.3;DISCUSSION;709
63.4;ACKNOWLEDGMENTS;711
63.5;REFERENCES;711
64;CHAPTER 58. IN VITRO SELECTION OF AN ATTENUATED VARIANT OF SINDBIS VIRUS;712
64.1;ABSTRACT;712
64.2;INTRODUCTION;713
64.3;RESULTS;713
64.4;DISCUSSION;720
64.5;ACKNOWLEDGEMENTS;721
64.6;REFERENCES;721
65;CHAPTER 59. VIRAL MUTATION IN PERSISTENT INFECTION;722
65.1;INTRODUCTION;723
65.2;METHODS;724
65.3;RESULTS;724
65.4;VIRI ON RNA TERMINI SHOW MUTATION DURING PERSISTENT INFECTION;725
65.5;VSV MUTANTS WITH ALTERED ABILITY TO INVOKE AND RESPOND TO NATURAL KILLER CELL DEFENSES;727
65.6;CAR 4 MUTANT VIRUS AFTER 5 YEARS SHOWS REDUCED NEUTRALIZATION KINETICS;731
65.7;SOME CAR 4 MUTANT CLONES EXHIBIT ALTERED PROTEIN PATTERNS;732
65.8;Dl PARTICLES APPEAR TO INCREASE THE MUTATION RATE OF INFECTIOUS VSV;732
65.9;VIRUS MUTANTS ARE SELECTED FOR RESISTANCE TO POPULATIONS OF DI PARTICLES PRESENT INITIALLY DURING PERSISTENT INFECTION;733
65.10;DISCUSSION;734
65.11;ACKNOWLEDGEMENTS;735
65.12;REFERENCES;735
66;CHAPTER 60. ANTIGENIC VARIATION OF VISNA VIRUS;738
66.1;INTRODUCTION;738
66.2;METHODS;740
66.3;RESULTS;741
66.4;DISCUSSION;749
66.5;ACKNOWLEDGEMENTS;751
66.6;REFERENCES;752
67;CHAPTER 61. POSSIBLE MECHANISM OF ROTAVIRUS PERSISTENCE;754
67.1;ABSTRACT;754
67.2;INTRODUCTION;754
67.3;RESULTS;756
67.4;DISCUSSION;763
67.5;ACKNOWLEDGMENTS;765
67.6;REFERENCES;765
68;CHAPTER 62. NEUROVIRULENCE AND PERSISTENCY OF MOUSE HEPATITIS VIRUSES IN RATS;766
68.1;INTRODUCTION;766
68.2;RESULTS;767
68.3;COMMENTS;773
68.4;ACKNOWLEDGEMENTS;773
68.5;REFERENCES;774
69;CHAPTER 63. PERSISTENT INFECTIONS OF BUNYAVIRUSES IN AEDES ALBOPICTUS;776
69.1;INTRODUCTION;776
69.2;METHODS;777
69.3;RESULTS;778
69.4;DISCUSSION;782
69.5;ACKNOWLE DGMENTS;783
69.6;REFERENCES;783
70;CHAPTER 64. EXPERIMENTAL RELAPSING MYELITIS IN HAMSTERS ASSOCIATED WITH A VARIANT OF MEASLES VIRUS;786
70.1;ABSTRACT;786
70.2;INTRODUCTION;786
70.3;MATERIALS AND METHODS;787
70.4;RESULTS;788
70.5;REFERENCES;794
71;CHAPTER 65. ANTIBODY-INDUCED MODULATION OF VIRAL ANTIGENS FROM INFECTED CELLS: BIOLOGICAL AND MOLECULAR STUDIES OF MEASLES VIRUS INFECTION AND IMPLICATIONS FOR UNDERSTANDING VIRUS PERSISTENCE AND RECEPTOR DISEASES;796
71.1;INTRODUCTION;797
71.2;MATERIALS AND METHODS;802
71.3;RESULTS;802
71.4;DISCUSSION;812
71.5;ACKNOWLEDGMENTS;815
71.6;REFERENCES;816
72;CHAPTER 66. WORKSHOP SUMMARY: HERPES AND POX VIRUS;818
72.1;References;824
73;CHAPTER 67. WORKSHOP #3 SUMMARY: ADENOVIRUSES /SV40/POLYOMA II;826
73.1;SV40–associated small RNA (SAS–RNA);826
73.2;Effect of deletions on late mRNA structure;828
73.3;Expression of rat insulin gene from SV40 vector;830
73.4;Adenovirus regulation;831
73.5;Functions of 72K polypeptide;832
73.6;REFERENCES;833
74;CHAPTER 68. WORKSHOP ON PICORNAVIRUSES/TOGAVIRUSES/HEPATITIS/ CORONAVI RUSES;836
74.1;Conveners;836
75;CHAPTER 69. WORKSHOP ON RHABDOVIRUSES AND PARAMYXOVIRUSES;838
76;CHAPTER 70. WORKSHOP SUMMARY: Segmented RNA Viruses, Dr. W. K. Joklik, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710;842
77;CHAPTER 71. WORKSHOP SUMMARY: CELL GENES AND VIRAL TRANSFORMATION;844
78;CHAPTER 72. WORKSHOP SUMMARY: Segmented RNA Viruses, Dr. W. K. Joklik, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710;842
79;CHAPTER 73. WORKSHOP SUMMARY: CELL GENES AND VIRAL TRANSFORMATION;844
80;CHAPTER 74. WORKSHOP SUMMARY;848
81;INDEX;854
82;FROM ACADEMIC PRESS, INC;862