E-Book, Englisch, 623 Seiten
Flockerzi / Nilius Transient Receptor Potential (TRP) Channels
1. Auflage 2007
ISBN: 978-3-540-34891-7
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 623 Seiten
ISBN: 978-3-540-34891-7
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
This volume provides up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression.
Autoren/Hrsg.
Weitere Infos & Material
1;Preface;6
2;List of Contents;8
3;Subject Index;11
4;An Introduction on TRP Channels;13
5;TRPC Channel Subfamily;32
5.1;TRPC1 Ca2+-Permeable Channels in Animal Cells;33
5.2;TRPC2: Molecular Biology and Functional Importance;63
5.3;TRPC3: AMultifunctional, Pore-Forming Signalling Molecule;86
5.4;Ionic Channels Formed by TRPC4;102
5.5;Canonical Transient Receptor Potential 5;118
5.6;TRPC6;133
5.7;TRPC7;150
6;TRPV Channel Subfamily;159
6.1;Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel;160
6.2;2-Aminoethoxydiphenyl Borate as a Common Activator of TRPV1, TRPV2, and TRPV3 Channels;177
6.3;TRPV4;192
6.4;TRPV5, the Gateway to Ca2+ Homeostasis;209
6.5;TRPV6;223
7;TRPM Channel Subfamily;237
7.1;TRPM2;238
7.2;TRPM3;254
7.3;Insights into TRPM4 Function, Regulation and Physiological Role;269
7.4;TRPM5 and Taste Transduction;286
7.5;TRPM6: A Janus-Like Protein;298
7.6;The Mg2+ and Mg2+-Nucleotide-Regulated Channel- Kinase TRPM7;311
7.7;TRPM8;327
8;Other TRP Channels;343
8.1;TRPA1;344
8.2;TRPP2 Channel Regulation;360
9;TRP Proteins and Specific Cellular Functions;373
9.1;Know Thy Neighbor: A Survey of Diseases and Complex Syndromes that Map to Chromosomal Regions Encoding TRP Channels;374
9.2;TRP Channels of the Pancreatic Beta Cell;404
9.3;TRP Channels in Platelet Function;420
9.4;TRP Channels in Lymphocytes;439
9.5;Link Between TRPV Channels and Mast Cell Function;451
9.6;TRPV Channels’ Role in Osmotransduction and Mechanotransduction;466
9.7;Nociception and TRP Channels;481
10;TRP Proteins – Integrators of Multiple Inputs;498
10.1;Regulation of TRP Ion Channels by Phosphatidylinositol- 4,5- Bisphosphate;499
10.2;TRPC, cGMP-Dependent Protein Kinases and Cytosolic Ca2+;516
10.3;Trafficking of TRP Channels: Determinants of Channel Function;530
10.4;TRPC Channels: Interacting Proteins;547
10.5;TRPC Channels: Integrators of Multiple Cellular Signals;563
10.6;Phospholipase C-Coupled Receptors and Activation of TRPC Channels;580
11;Subject Index;602
12;Publisher’s Erratum to Transient Receptor Potential ( TRP) Channels;610
13;List of Contributors;610
