Florkin / Stotz Hydrolytic Reactions

Cobamide and Biotin Coenzymes
1. Auflage 2014
ISBN: 978-1-4832-2213-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 16, 280 Seiten, Web PDF

Reihe: Comprehensive Biochemistry

Comprehensive Biochemisty, Volume 16: Hydrolytic Reactions; Cobamide and Biotin Coenzymes treats both the chemistry and function of the coenzymes. This book discusses the thermodynamic and kinetic aspects of enzyme catalysis, hydrolytic enzymes displaying 'active center characteristics, chelation and stereochemical considerations in enzyme catalysis, and biological oxidation mechanisms. The recommendations of the Enzyme Commission of the International Union of Biochemistry and classified list of enzymes are also covered. This publication likewise elaborates the spectral characteristics of the cobamide coenzymes and mode of binding of biotin. Other topics include the classification of carboxyl esterases, structure and reactivity of phosphorylated metabolites, and mechanism of action of chymotrypsin. This volume is a good reference for biochemists and specialists concerned with enzymes.

Autoren/Hrsg.

Florkin, Marcel

Stotz, Elmer H.

Inhaltsverzeichnis

1;Front Cover;1
2;Hydrolytic Reactions; Cobamide and Biotin Coenzymes;6
3;Copyright Page;3
4;Table of Contents;10
5;CONTRIBUTORS TO THIS VOLUME;7
6;GENERAL PREFACE;8
7;PREFACE TO SECTION III;9
8;Chapter I. Cholinesterases, Esterases and Lipases;14
8.1;1. Introduction;14
8.2;2. Classification of carboxyl esterases;15
8.3;3. Mechanism of action of carboxyl esterases;17
8.4;4. Cholinesterases;22
8.5;5. Esterases;48
8.6;6. Lipases;51
8.7;REFERENCES;60
9;Chapter II. Phosphatases;68
9.1;1. Structure and reactivity of phosphorylated metabolites;68
9.2;2. Hydrolysis of phosphates;71
9.3;3. The water site of phosphohydrolases;77
9.4;4. Phosphorylation of phosphatase;78
9.5;5. Specificity toward phosphorylated compounds;79
9.6;6. Properties of some phosphatases;81
9.7;7. Physiological functions of phosphatases;91
9.8;8. Epilogue;93
9.9;REFERENCES;94
10;Chapter III. The Structure and Mechanism of Action of Proteolytic Enzymes;98
10.1;1. Introduction;98
10.2;2. Serine proteases;99
10.3;3. Thiol proteases;153
10.4;4. Metallo-proteinases;164
10.5;5. Acid proteases;186
10.6;REFERENCES;193
11;Chapter IV. The Cobamide Coenzymes;202
11.1;1. Introduction;202
11.2;2. Structure;203
11.3;3. Isolation and distribution of the cobamide coenzymes;204
11.4;4. Spectral characteristics of the cobamide coenzymes;205
11.5;5. Degradation and inactivation of the cobamide coenzymes;206
11.6;6. Conversion of vitamin B12 to B12 coenzyme;212
11.7;7. The mechanism of cobamide-coenzyme dependent reactions;216
11.8;ADDENDUM;220
11.9;REFERENCES;221
12;Chapter V. Carboxylases and the Role of Biotin;223
12.1;1. Classification of carboxylases;223
12.2;2. Biotin and its metabolic functions;225
12.3;3. Biotin enzymes;228
12.4;4. Mode of binding of biotin;245
12.5;5. Mechanism of action of biotin;247
12.6;REFERENCES;259
13;SUBJECT INDEX;264