Geller Advances in Clinical Trial Biostatistics

1. Auflage 2003
ISBN: 978-1-135-52438-8
Verlag: CRC Press
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 271 Seiten

Reihe: Chapman & Hall/CRC Biostatistics Series

From aspects of early trials to complex modeling problems, Advances in Clinical Trial Biostatistics summarizes current methodologies used in the design and analysis of clinical trials. Its chapters, contributed by internationally renowned methodologists experienced in clinical trials, address topics that include Bayesian methods for phase I clinical trials, adaptive two-stage clinical trials, and the design and analysis of cluster randomization trials, trials with multiple endpoints, and therapeutic equivalence trials. Other discussions explore Bayesian reporting, methods incorporating compliance in treatment evaluation, and statistical issues emerging from clinical trials in HIV infection.

Zielgruppe

Biostatisticians, statistical clinical trialists, statistical drug developers and researchers, and graduate students in these disciplines

Autoren/Hrsg.

Geller, Nancy L.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Bayesian Methods for Cancer Phase I Clinical Trials
James S. Babb and André Rogatko

Design of Early Trials in Stem Cell Transplantation: A Hybrid Frequentist-Bayesian Approach

Nancy L. Geller, Dean Follmann, Eric S. Leifer, and Shelly L. Carter

Design and Analysis of Therapeutic Equivalence Trials

Richard M. Simon

Adaptive Two-Stage Clinical Trials

Michael A. Proschan

Design and Analysis of Cluster Randomization Trials
David M. Zucker

Design and Analysis of Clinical Trials with Multiple Endpoints
Nancy L. Geller

Subgroups and Interactions
Dean Follmann

A Class of Permutation Tests for Some Two-Sample Survival Data Problems
Joanna H. Shih and Michael P. Fay

Bayesian Reporting of Clinical Trials
Simon Weeden, Laurence S. Freedman, and Mahesh Parmar

Methods Incorporating Compliance in Treatment Evaluation

Juni Palmgren and Els Goetghebeur

Analysis of Longitudinal Data with Missingness
Paul S. Albert and Margaret C. Wu

Statistical Issues Emerging from Clinical Trials in HIV Infection
Abdel Babiker and Ann Sarah Walker