Goldfine / Shen Listeria monocytogenes: Pathogenesis and Host Response

1. Auflage 2007
ISBN: 978-0-387-49376-3
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 287 Seiten

During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.

Autoren/Hrsg.

Goldfine, H.

Shen, H.

Goldfine, Howard

Shen, Hao

Inhaltsverzeichnis

1;Preface;5
2;Contents;7
3;Contributors;9
4;A 20-Year Perspective on Listeria monocytogenes Pathogenesis;13
4.1;1.1. Introduction;13
4.2;1.2. The Beginning of the Modern Era: A Personal Recollection;13
4.3;1.3. Natural History of Infection;16
4.4;1.4. Genetics, Genomics, and Gene Regulation;16
4.5;1.5. Models of Infection;17
4.6;1.6. Cell Biology of Infection ;17
4.7;1.7. Relating Pathogenesis to Immunity;19
4.8;1.8. Future Prospects/Unanswered Questions;19
4.9;References;20
5;Listeriosis;25
5.1;2.1. Introduction;25
5.2;2.2. Microbiology;25
5.3;2.3. Epidemiology;26
5.4;2.4. Pathogenesis;28
5.5;2.5. Immunity;29
5.6;2.6. Clinical Manifestations;30
5.7;2.7. Diagnosis;34
5.8;2.8. Treatment;35
5.9;2.9. Prevention;36
5.10;References;37
6;Listeria Genomics;44
6.1;3.1. Introduction;44
6.2;3.2. Genome Comparisons ;46
6.3;3.3. Specific Features of the L. monocytogenes Genomes;53
6.4;3.4. Diversity Within the Species L. monocytogenes;58
6.5;3.5. Postgenomics Analysis—Functional Genomics ;63
6.6;3.6. Conclusions and Further Perspectives;66
6.7;References;68
7;Metabolism and Physiology of Listeria monocytogenes;74
7.1;4.1. Introduction;74
7.2;4.2. Carbon Metabolism;76
7.3;4.3. Anabolic Pathways;81
7.4;4.4. Nitrogen Metabolism;83
7.5;4.5. Conclusions;85
7.6;References;87
8;The Cell Wall of Listeria monocytogenes and its Role in Pathogenicity;92
8.1;5.1. Introduction;92
8.2;5.2. Biochemistry of the Listeria monocytogenes Cell Wall;93
8.3;5.3. Listeria monocytogenes Surface Proteins Anchored to the Cell Wall;97
8.4;5.4. Role of Cell-Wall-Associated Proteins in Listeria monocytogenes Virulence;103
8.5;5.5. Proteomics of the Listeria monocytogenes Cell Wall;107
8.6;5.6. The Listeria monocytogenes Cell Wall and Inflammation ;110
8.7;5.7. Future Challenges;112
8.8;Note;113
8.9;References;113
9;Environmental Reservoir and Transmission into the Mammalian Host;122
9.1;6.1. Introduction;122
9.2;6.2. Methods for Studying L. monocytogenes Transmission;123
9.3;6.3. Listeria monocytogenes in Natural and Other Nonagricultural Environments;125
9.4;6.4. Listeria monocytogenes in Agricultural Environments;128
9.5;6.5. Listeria monocytogenes in Food-Associated Environments and Foods;131
9.6;6.6. Transmission into the Mammalian Host;136
9.7;6.7. Overall L. monocytogenes Transmission and Conclusions;139
9.8;References;140
9.9;Abbreviations;148
10;Regulation of Listeria monocytogenes Virulence Genes;149
10.1;7.1. Introduction;149
10.2;7.2. Regulation of PrfA Activity;150
10.3;7.3. Touched by the Regulator: Gene Products Whose Expression is Modulated by PrfA;157
10.4;7.4. Regulatory Factors, Other Than PrfA, Thus Far Implicated in the Control of L. monocytogenes Virulence Gene Expression;162
10.5;7.5. Concluding Remarks;163
10.6;References;164
11;Invasion of Host Cells by Listeria monocytogenes;169
11.1;8.1. Introduction;169
11.2;8.2. Internalins: Main Listeria monocytogenes Effectors for Cell Invasion;171
11.3;8.3. Other Molecules Involved in Invasion ;180
11.4;8.4. Conclusions;182
11.5;References;182
12;Escape of Listeria monocytogenes from a Vacuole;187
12.1;9.1. Introduction;187
12.2;9.2. Escape from the Primary Vacuole ;188
12.3;9.3. Escape from the Secondary Vacuole;196
12.4;9.4. Coda;199
12.5;References;200
13;Actin-Based Motility and Cell-to-Cell Spread of Listeria monocytogenes;206
13.1;10.1. Introduction ;206
13.2;10.2. Intracellular Bacterial Movement ;210
13.3;10.3. The ActA Surface Protein ;211
13.4;10.4. Host Contributions to Actin-Based Motility ;215
13.5;10.5. Biophysics of Actin-Based Movement;222
13.6;10.6. Conclusions;224
13.7;References;225
14;Adaptive Immunity to Listeria monocytogenes;233
14.1;11.1. Murine Infection with Listeria monocytogenes as a Model Intracellular Pathogen;233
14.2;11.2. Adaptive Immunity to L. monocytogenes;234
14.3;11.3. Initiation of T-Cell-Mediated Immunity to L. monocytogenes;235
14.4;11.4. Kinetics of the T-Cell Response to L. monocytogenes ;239
14.5;11.5. Programming of the T-Cell Response;242
14.6;11.6. Secondary Immunity to L. monocytogenes;243
14.7;11.7. CD8+ T- Cell Effector Mechanisms;245
14.8;11.8. Conclusion;249
14.9;References;249
15;Immune Evasion and Modulation by Listeria monocytogenes;258
15.1;12.1. Introduction: Evasion and Modulation of the Immune Response by Pathogens;258
15.2;12.2. Murine Listeriosis as a Model to Study Infection and Immunity;259
15.3;12.3. The Intracellular Niche of L. monocytogenes and Evasion of Immune Responses;260
15.4;12.4. Listeria monocytogenes-Induced Apoptosis Modulates the Immune Response;263
15.5;12.5. Evasion of CD8 T Cell-Mediated Protective Immunity;264
15.6;12.6. Induction of Type I Interferons by L. monocytogenes is Beneficial to the Bacteria;265
15.7;12.7. Conclusions;266
15.8;References;267
16;Bacteriophages of Listeria;271
16.1;13.1. Bacteriophages ;271
16.2;13.2. Listeria Phages ;275
16.3;References;282
17;Index;286