Goldstein / Mackay The Human Thymus

1. Auflage 2016
ISBN: 978-1-4831-9285-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 368 Seiten, Web PDF

The Human Thymus presents the immunological aspect of the thymus. It discusses the lymphopoietic and immunological functions of the human thymus. It addresses the physiological function of thymus that regulates neuromuscular transmission by the secretion of thymin. Some of the topics covered in the book are the origin of thymic lymphocytes; development of Hassall's corpuscles; humoral immune responses; neonatal thymectomy and wasting disease; mode of action of thymin at the neuromyal synapse; experimental autoimmune thymitis; and neuromuscular block associated with experimental autoimmune thymitis. The diseases induced with Freund's complete adjuvant are covered. The spontaneously occurring autoimmune diseases are discussed. The text describes the size of the human thymus. A study of the experimental effect of hormones on thymic size is presented. A chapter is devoted to the thymic hypoplasia and immunological deficiencies. Another section focuses on the histopathology of thymus in myasthenia gravis. The book can provide useful information to scientists, doctors, students, and researchers.

Autoren/Hrsg.

Goldstein, Gideon

Mackay, Ian R.

Inhaltsverzeichnis

1;Front Cover;1
2;The Human Thymus;4
3;Copyright Page;5
4;Table of Contents
;6
5;Dedication
;8
6;FOREWORD;10
7;PREFACE;12
8;ACKNOWLEDGEMENTS;16
9;CHAPTER ONE. STRUCTURE AND DEVELOPMENT OF THE HUMAN THYMUS;18
9.1;Anatomy;18
9.2;Histology;20
9.3;Electron Microscopy;31
9.4;Histological Changes with Age;46
9.5;Synopsis;50
9.6;References;50
10;CHAPTER TWO. FUNCTIONS OF THE THYMUS;54
10.1;Immunological Functions of the Thymus;54
10.2;Endocrine Function of the Thymus Affecting Neuromuscular Transmission;77
10.3;Synopsis;89
10.4;References;90
11;CHAPTER THREE. THE THYMUS AND EXPERIMENTAL PATHOLOGY;103
11.1;Neuromuscular Disease;103
11.2;Other Experimentally Induced Autoimmune Diseases;120
11.3;Spontaneously Occurring Autoimmune Diseases;122
11.4;Immunological Deficiency Disease;132
11.5;Murine Leukaemia;133
11.6;Cancer;134
11.7;Synopsis;136
11.8;References;137
12;CHAPTER FOUR. SIZE OF THE HUMAN THYMUS;145
12.1;The weight of the normal human thymus;145
12.2;Stress involution;148
12.3;Experimental studies on the effect of hormones on thymic size;148
12.4;Small Thymus in Man;150
12.5;Large Thymus in Man;151
12.6;Synopsis;152
12.7;References;153
13;CHAPTER FIVE. THYMIC HYPOPLASIA AND IMMUNOLOGICAL DEFICIENCIES;157
13.1;The mammalian analogue of the avian bursa;157
13.2;Main Types of Thymus-Related Immunological Deficiency Disease;158
13.3;Synopsis;176
13.4;References;177
14;CHAPTER SIX. THYMITIS AND MYASTHENIA GRAVIS;182
14.1;Histopathology of Thymus in Myasthenia Gravis;182
14.2;The Serological Abnormality of Myasthenia Gravis;191
14.3;The Aetiology of Thymitis in Myasthenia Gravis;194
14.4;Thymitis and Neuromuscular Block;198
14.5;Muscle Pathology in Myasthenia Gravis;200
14.6;Thymectomy in Myasthenia Gravis;202
14.7;Synopsis;203
14.8;References;204
15;CHAPTER SEVEN. THYMIC TUMOURS AND SYSTEMIC DISEASES ASSOCIATED WITH THYMOMA;211
15.1;Classification and Types of Thymomas;211
15.2;Ectopic Thymoma;220
15.3;Malignant Lymphoma, Including Hodgkin's Disease;220
15.4;Metastatic Carcinoma;222
15.5;Malignancy of Thymomas;222
15.6;Thymic Cysts;224
15.7;Thymoma and Systemic Diseases;224
15.8;Synopsis;236
15.9;References;237
16;CHAPTER EIGHT. THE HUMAN THYMUS IN EXTRA-THYMIC DISEASES;245
16.1;Severe Illness;245
16.2;Bacterial Infections;246
16.3;Myasthenia Gravis;246
16.4;Systemic Lupus Erythematosus;247
16.5;Thyroid Disease;259
16.6;Autoimmune Haemolytic Anaemia;262
16.7;Miscellaneous Diseases;263
16.8;Leukaemia and Reticuloses;267
16.9;Cancer;267
16.10;Infectious Diseases;267
16.11;Synopsis;268
16.12;References;269
17;CHAPTER NINE. CLINICAL INVESTIGATION OF THE THYMUS AND RELATED DISEASES;272
17.1;Clinical examination;272
17.2;Thymic radiology;272
17.3;Radioisotopic scanning of the thymus;287
17.4;Mediastinoscopy;293
17.5;Biopsy and histological examination of the thymus;293
17.6;Thymic weight;296
17.7;Investigation of Diseases Associated with Abnormality of the Thymus;296
17.8;Thymic hypoplasia;296
17.9;Thymitis and myasthenia gravis;297
17.10;Thymoma;299
17.11;Synopsis;300
17.12;References;301
18;CHAPTER TEN. TREATMENT OF THYMIC DISEASES AND RELATED SYSTEMIC DISEASES;304
18.1;Thymic Hypoplasia with Immune Deficiency;304
18.2;Thymic Hyperplasia;307
18.3;Autoimmune Thymitis with Myasthenia Gravis;308
18.4;Thymoma;318
18.5;Thymectomy for Leukaemia and Lymphoma;320
18.6;Thymectomy for Erythroid Aplasia;321
18.7;Thymectomy and Autoimmune Disease;322
18.8;Thymectomy and Organ Transplantation;324
18.9;'Experimental' Thymectomy in Man;325
18.10;Thymectomy versus Antilymphocyte Serum;325
18.11;Synopsis;325
18.12;References;327
19;APPENDIXES;334
19.1;APPENDIX I: CASES OF THYMIC TUMOUR AND;335
19.2;HYPOPLASIA OF BONE MARROW;336
19.3;APPENDIX II: CASES OF THYMIC TUMOUR AND;355
19.4;IMMUNOGLOBULIN DEFICIENCY;356
20;INDEX;364