Goss / Kahn Targeting the Wnt Pathway in Cancer

2011
ISBN: 978-1-4419-8023-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 240 Seiten, eBook

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Zielgruppe

Research

Autoren/Hrsg.

Goss, Kathleen H.

Kahn, Michael

Inhaltsverzeichnis

Chapter 1. An Introduction to Wnt Signaling Paul Polakis  Chapter 2. Regulation of Wnt Secretion and DistributionXiaofang Tang Xiaolan Fan and Xinhua Lin Chapter 3. Wnt Signaling in Stem CellsPhilipp C. Manegold, Jia-Ling and Teo Michael KahnChapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon CancerMasahiro Aoki and Makoto Mark Taketo Chapter 8. Targeting Wnt Signalling in CancerAliaksei Holik and Alan R. ClarkeCardiff School of Biosciences, Cardiff University,Cardiff, UK Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng Chapter 10. Targeting of Wnt Signaling Inside the NucleusMiki Shitashige and Tesshi YamadaMarkus MüschenChapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon CancerMasahiro Aoki and Makoto Mark Taketo Chapter 8. Targeting Wnt Signalling in CancerAliaksei Holik and Alan R. ClarkeCardiff School of Biosciences, Cardiff University,Cardiff, UK Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng Chapter 10. Targeting of Wnt Signaling Inside the NucleusMiki Shitashige and Tesshi Yamada Chapter 4. Crosstalk of the Wnt Signaling PathwayMichael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga Chapter 5. Dysregulation of the WNT Pathway in Solid TumorsJenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss Chapter 6. WNT/b-catenin Signaling in LeukemiaMarkus MüschenChapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon CancerMasahiro Aoki and Makoto Mark Taketo Chapter 8. Targeting Wnt Signalling in CancerAliaksei Holik and Alan R. ClarkeCardiff School of Biosciences, Cardiff University,Cardiff, UK Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng Chapter 10. Targeting of Wnt Signaling Inside the NucleusMiki Shitashige and Tesshi Yamada