Gustafson / Taylor / Stacey Genomics of Disease

1. Auflage 2008
ISBN: 978-0-387-76723-9
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 222 Seiten

This title develops from the 24th Stadler symposium. It explores the general theme 'GENOME EXPLOITATION: Data Mining the Genomes'. The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book presents a state-of-the-art picture on mining the Genome databases. Its chapters are authored by key stars in the field.

Autoren/Hrsg.

Gustafson, JP

Taylor, J.

Stacey, G.

Gustafson, J.P.

Tayler, J.

Stacey, Glyn

Inhaltsverzeichnis

1;Acknowledgments;6
2;Contents;7
3;Contributors;9
4;Roles of Plant Hormones in Plant Resistance and Susceptibility to Pathogens;17
4.1;1 Introduction;17
4.2;2 Flg22 Triggers Auxin-Signaling Repression by Inducing a Specific miRNA;18
4.3;3 Does Auxin Play a Role in Bacterial Pathogenenity?;21
4.4;4 Flg22 Triggers Growth Inhibition of Arabidopsis Seedlings;22
4.5;5 Role of DELLA Proteins in Plant Disease Resistance and Susceptibility;23
4.6;6 Are DELLA Proteins Integrators of Plant Defense Pathways?;24
4.7;References;25
5;Canine Genetics Facilitates Understanding of Human Biology;27
5.1;1 Introduction to Dogs and Breeds;27
5.2;2 Mapping Disease Genes in Dogs;28
5.3;3 Canine Breed Relationships;31
5.4;4 Advances in Canine Genomics;32
5.5;5 Mapping Genes for Morphology in the Dog;35
5.6;6 Summary and Future Aims;36
5.7;References;37
6;Xanthomonas oryzae pv. oryzae AvrXA21 Activity Is Dependent on a Type One Secretion System, Is Regulated by a Two- Component Regulatory System that Responds to Cell Population Density, and Is Conserved in Other Xanthomonas spp.;41
6.1;1 Detection of Pathogens by Plants and Animal Hosts;42
6.2;2 The PRR XA21 Represents a Large Class of Kinases Predicted to Be Involved in Innate Immunity;44
6.3;3 AVRXA21 Activity Requires a Type One Secretion System;44
6.4;4 The AVRXA21 Pathogen-Associated Molecule Is Conserved in Xanthomonas campestris pv. campestris;47
6.5;5 Cell Density Dependent Expression of Rax Genes;48
6.6;6 Perspective;50
6.7;References;53
7;Unraveling the Genetic Mysteries of the Cat: New Discoveries in Feline- Inherited Diseases and Traits;57
7.1;1 Cat Phenotypes;57
7.2;2 Cat Diseases;60
7.3;3 Feline Genetic Resources;63
7.4;4 Reproductive Technologies;64
7.5;5 Future of Cat Genetics;65
7.6;References;66
7.7;APPENDIX: Table references;70
8;Variation in Chicken Gene Structure and Expression Associated with Food-Safety Pathogen Resistance: Integrated Approaches to Salmonella Resistance;73
8.1;1 Rationale and Strategies for Uncovering Genetic Resistance to Food- Safety Pathogens in Poultry;73
8.2;2 Genetic Control of Salmonella Resistance in Poultry;77
8.3;3 Conclusions;79
8.4;References;80
9;Functional Genomics and Bioinformatics of the Phytophthora sojae Soybean Interaction;83
9.1;1 Introduction;83
9.2;2 Sequencing of Oomycete Genomes;85
9.3;3 Effector Genes in Oomycete Genomes;86
9.4;4 Counter-Play of Plant and Pathogen Genes During Phytophthora Infection of Soybean;89
9.5;References;92
10;Canine SINEs and Their Effects on Phenotypes of the Domestic Dog;95
10.1;1 Short Interspersed Elements;95
10.2;2 Merle Patterning;96
10.3;3 A-Tails Are Important;100
10.4;4 Summary;101
10.5;References;101
11;Ovine Disease Resistance: Integrating Comparative and Functional Genomics Approaches in a Genome Information- Poor Species;104
11.1;1 Introduction;105
11.2;2 Tools Used to Obtain Candidate Genes 2.1 Resource Flocks for QTL Analysis and Mapping;107
11.3;2.2 Integrated Maps, Comparative Mapping and Meta-analysis;107
11.4;2.3 Association Studies, SNP Chips and LD Mapping;109
11.5;2.4 Microarrays, SELDI-TOF MS and Other High Density Genomic or Proteomic Functional Tools;113
11.6;2.5 Positional Functional Integration;114
11.7;3 An Example: Mapping Genes for Ruminant Fasciolosis;115
11.8;3.1 Resistance to Fasciola;116
11.9;3.2 The Resource Flock for Mapping Fasciolosis Resistance;116
11.10;3.3 Linkage and QTL Analysis for Fasciolosis;117
11.11;3.4 Mapping Fasciolosis QTL in Cattle and Buffalo;120
11.12;3.5 Immunological Characterisation for Functional Positional Integration;120
11.13;3.6 High Density Proteomic and Genomic Functional Screening;122
11.14;3.7 Future Studies and Potential Applications;122
11.15;References;124
12;Integrating Genomics to Understand the Marek’s Disease Virus – Chicken Host – Pathogen Interaction;129
12.1;1 Introduction;129
12.2;2 Marek’s Disease;130
12.3;2.1 MD as a Model;131
12.4;2.2 Genetic Resistance;131
12.5;3 Integrating Genomics, Version 1.0 (Before the Genome Sequence);132
12.6;3.1 Genome-Wide QTL Scans;133
12.7;3.2 Gene Profiling;134
12.8;3.3 VirusÒHost ProteinÒProtein Interaction Screens;134
12.9;4 Integrating Genomics, Version 2.0 (After the Genome Sequence);136
12.10;4.1 Genome-Wide QTL Scans;136
12.11;4.2 Gene Profiling;137
12.12;4.3 VirusÒHost ProteinÒProtein Interaction Screens;137
12.13;5 Some Final Thoughts;138
12.14;References;138
13;Combining Genomic Tools to Dissect Multifactorial Virulence in Pseudomonas aeruginosa;141
13.1;1 Introduction;141
13.2;2 Background 2.1 Pseudomonas aeruginosa is an Opportunistic Human Pathogen;142
13.3;2.2 The Model Host System for Studying Pathogenesis;143
13.4;3 Genomic Sequence of P. aeruginosa, Strain PA14 3.1 Comparative Alignments with Strain PAO1;145
13.5;3.2 Annotation of the PA14 Genome;148
13.6;4 Relationship Between Genomic Content and Virulence 4.1 Conservation of PA14- Specific Genes and Their Potential Role in Virulence;151
13.7;4.2 Identification of PA14-specific Virulence Genes and Their Conservation in Other Strains;153
13.8;5 Future Directions: Testing Additional Model Hosts;156
13.9;5.1 Wax Moth Injection Model;156
13.10;5.2 Wax Moth Feeding Model;159
13.11;6 Discussion;160
13.12;References;162
14;Genetic Dissection of the Interaction Between the Plant Pathogen Xanthomonas campestris pv. vesicatoria and Its Host Plants;165
14.1;1 Introduction;165
14.2;2 Results and Discussion 2.1 The T3SS of Xcv;167
14.3;2.2 Control of T3S by Xcv;168
14.4;2.3 The AvrBs3 Effector Protein;168
14.5;2.4 Plant Target Proteins of AvrBs3;169
14.6;2.5 Plant Target Genes of AvrBs3;170
14.7;References;172
15;Structure and Function of RXLR Effectors of Plant Pathogenic Oomycetes;175
15.1;1 Introduction;175
15.2;2 The RXLR Sequence Defines a Conserved Domain of Oomycete Avr Proteins;176
15.3;3 The Phytophthora RXLR Domain Mediates Host Targeting in Plasmodium;178
15.4;4 The RXLR Domain Is Not Required for Effector Activities;179
15.5;5 The C-Terminal Region of RXLR Effectors Is Typically More Polymorphic than the Signal Peptide and RXLR Domains;179
15.6;6 Can RXLR Effectors Enter Host Plants in the Absence of the Pathogen?;180
15.7;7 A Model for RXLR Effector Delivery into the Host;181
15.8;8 Virulence Functions of RXLR Effectors;182
15.9;9 Outlook: Too Many Effectors, Too Little Time;183
15.10;References;183
16;The Biotrophic Phase of Ustilago maydis: Novel Determinants for Compatibility;186
16.1;1 Introduction;186
16.2;2 Ustilago maydis Does Not Use Aggressive Infection Strategies;189
16.3;3 Ustilago maydis Regulates its Interaction with the Host via a Set of Novel Secreted Protein Effectors;190
16.4;4 Discussion and Outlook;192
16.5;References;193
17;Virulence Evolution in Malaria;195
17.1;1 A Hypothesis for Pathogen Virulence;195
17.2;2 Malaria;197
17.3;2.1 Mouse Malaria;198
17.4;2.2 Human Malaria;198
17.5;2.3 Consequences of Malaria Vaccination;201
17.6;3 Vaccine-Driven Virulence Evolution in Other Diseases;205
17.7;4 Conclusions;206
17.8;References;207
18;The Ins and Outs of Host Recognition of Magnaporthe oryzae;210
18.1;1 Sequence Analysis of the AVR1-CO39 Locus;213
18.2;2 Distribution of AVR1-CO39-Like Sequences in Grass-Infecting Isolates of M. orzyae;216
18.3;3 Structure of AVR1-CO39 in Non-rice-Infecting Isolates of M. orzyae;217
18.4;4 Structure of AVR1-CO39 Locus in Rice Isolates of M. oryzae;218
18.5;5 Genetic and Physical Mapping of the Pi-CO39 (t) Locus;218
18.6;6 Comparative DNA Sequence Analysis of Resistant and Susceptible Cultivars at the Pi- CO39 ( t) Locus;219
18.7;+;221
18.8;References;222
19;Index;228