Haga / Takeda G Protein-Coupled Receptors

Structure, Function, and Ligand Screening
Erscheinungsjahr 2010
ISBN: 978-1-4200-3827-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 336 Seiten

Reihe: Methods in Signal Transduction Series

This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

Zielgruppe

Biochemists, molecular biologists, pharmacologists, neurobiologists, cell biologists, and pharmaceutical scientists.

Autoren/Hrsg.

Haga, Tatsuya

Takeda, Shigeki

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Screening of Ligands for GPCRs

Screening of Endogenous Ligands for Orphan GPCRs, M. Mori, S. Hinuma, T. Ohtaki, and M. Fujino

Screening of Ligands for Human GPCRs by the Use of Receptor-Ga ( Fusion Proteins, S. Takeda, H. Suga, and T. Haga

Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor, M. Kojima and K. Kangawa

Ligand Screening of Olfactory Receptors, K. Touhara, S. Katada, T. Nakagawa, and Y. Oka

Functions and Regulations of GPCRs

Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice, J. Wess, D. Gautam, S.-J. Han, J. Jeon, C. Li, and C. Deng

Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors, E.C. Hulme

Analysis of the Regulation of Muscarinic Acetylcholine Receptors, C.J. Van Koppen

Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells, M. Ueda, Y. Miyanaga, and T. Yanagida

Oligomerization of G Protein-Coupled Purinergic Receptors, H. Nakata, K. Yoshioka, and T. Kamiya Tertiary Structure of GPCRs and Their Ligands

Methods and Results in X-Ray Crystallography of Bovine Rhodopsin, T. Okada, R. Tsujimoto, M. Muraoka, and C. Funamoto

Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect), H. Furukawa, T. Hamada, H. Hirota, M. Ishiguro, and T. Haga

Modeling of G Protein-Coupled Receptors for Drug Design, M. Ishiguro

Index