Hall Developmental and Cellular Skeletal Biology

1. Auflage 2013
ISBN: 978-1-4832-6721-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 314 Seiten, Web PDF

Developmental and Cellular Skeletal Biology reviews the development, growth, and cell biology of the skeleton. The monograph provides a comprehensive overview of the aspects of skeletal biology, focusing mainly on the cellular level. It covers topics on the types of skeletal tissues, its evolution, and origin; location of the skeleton within the embryo; initiation of centers of skeletogenesis; and the initiation of skeletal growth. The book will be of great use to physiologists, cell biologists, hematologists, pathologists, orthopedic surgeons, and others whose professions are concerned with the study of the skeletal system.

I have been interested in and studying skeletal tissues since my undergraduate days in Australia in the 1960s. Those early studies on the development of secondary cartilage in embryonic birds, first published in 1967, have come full circle with the discovery of secondary cartilage in dinosaurs12. Bird watching really is flying reptile watching. Skeletal tissue development and evolution, the embryonic origins of skeletal tissues (especially those that arise from neural crest cells), and integrating development and evolution in what is now known as evo-devo have been my primary preoccupations over the past 50+ years.

Autoren/Hrsg.

Hall, Brian K.

Inhaltsverzeichnis

1;Front Cover;1
2;Developmental and Cellular Skeletal Biology;4
3;Copyright Page ;5
4;Table of Contents;6
5;Preface;10
6;CHAPTER 1. TYPES OF SKELETAL TISSUES;12
6.1;I. Introduction;12
6.2;II. Bone;12
6.3;III. Cartilage;18
6.4;IV. Enamel;23
6.5;V. Dentine;23
6.6;VI. Intermediate Tissues;24
7;CHAPTER 2. THE EVOLUTION OF SKELETAL TISSUES;32
7.1;Text;32
8;CHAPTER 3. THE ORIGIN OF SKELETAL CELL TYPES;37
8.1;I. Stem Cells;37
8.2;II. Modulation of Synthetic Activity;40
8.3;III. Precursor Cells;43
8.4;IV. Specificity of Embryonic Induction;46
9;CHAPTER 4. LOCATION OF THE SKELETON WITHIN THE EMBRYO;48
9.1;I. Introduction;48
9.2;II. The Skeleton of the Neural Crest;48
9.3;III. The Limb Skeleton;69
9.4;IV. The Vertebral Skeleton;89
9.5;V. The Auditory Cartilage;93
9.6;VI. Ectopic Skeletogenesis;93
10;CHAPTER 5. INITIATION OF CENTERS OF SKELETOGENESIS;97
10.1;I. Introduction;97
10.2;II. Mesenchymal Condensations in the Developing Limb Bud;99
10.3;III. Mechanisms Invoked for Initiation of Condensations;107
10.4;IV. Hyaluronic Acid and the Initiation of Condensations;110
11;CHAPTER 6. PROGENITOR CELLS AND THEIR DIFFERENTIATION;118
11.1;I. Introduction;118
11.2;II. Osteo- and Chondroprogenitor Cells;119
11.3;III. Progenitor Cells for Osteoblasts and Osteoclasts;120
11.4;IV. Progenitor Cells for Osteoblasts and Chondroblasts;123
11.5;V. Dedifferentiation as a Source of Progenitor Cells;126
11.6;VI. The Differentiation of Progenitor Cells;135
12;CHAPTER 7. MAINTENANCE OF THE DIFFERENTIATED STATE;159
12.1;I. Introduction;159
12.2;II. Maintenance of the Differentiated Chondrocyte;160
12.3;III. Maintenance of the Differentiated Osteocyte;197
13;CHAPTER 8. POLARITY AND MORPHOGENESIS;203
13.1;I. Introduction;203
13.2;II. Establishment of Axes and Polarity during Limb Development;206
13.3;III. Mechanisms of Morphogenesis;210
14;CHAPTER 9. INITIATION OF SKELETAL GROWTH;217
14.1;I. Introduction;217
14.2;II. Components of Skeletal Growth;218
15;Appendix;238
16;Bibliography;240
17;Author Index;278
18;Subject Index;296