Harris Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy
2007
ISBN: 978-1-4020-5688-8
Verlag: Springer Netherland
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)

E-Book, Englisch, Band 42, 324 Seiten, eBook

Reihe: Subcellular Biochemistry

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Zielgruppe

Research

Autoren/Hrsg.

Harris, Randall E.

Inhaltsverzeichnis

Historical Perspectives.- Anti-Inflammatory Drugs in the 21st Century.- Inflammatory Mechanisms of Pathogenesis.- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus.- Obesity, Inflammation, and Vascular Disease.- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer.- Role of COX-2 in Inflammatory and Degenerative Brain Diseases.- Inflammation and Cardiovascular Disease: The Coxib Controversy.- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors.- COX-2 Inhibitors And Cardiovascular Risk.- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib.- Cox-2 Blockade in Cancer Prevention and Therapy.- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade.- Strategies for Colon Cancer Prevention.- Inflammation and Neurodegenerative Disease.- NSAIDs for the Chemoprevention of Alzheimer’s Disease.- Inflammation in parkinson’s disease.- Nutrition, Inflammation and Chronic Disease.- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases.- Nutritional Intervention in Brain Aging.